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KELOMPOK 10

Rizki Setianingsih 4401414006


Rifki Dwi Anisa 4401414016
Perangkat yang Diperlukan dalam Sintesis Protein
RNA (Ribonucleid Acid)
Tipe Molekul RNA
1. RNA mesangger (RNAm)
a. dicetak oleh DNA dalam inti
b. pembawa informasi genetik dari DNA
berbentuk triplet disebut kodon
2. RNA transfer (RNAt) 3
A
Amino acid C
a. terdapat empat attachment site C
A 5

daerah dengan basa G


C G
C
C G
yang berpasangan dan U
U
G
A
saling berikatan U C
A
A
U
U
* C A C A G U A G
A *
* C U C
b. basa yang tidak G
C G U G U * C G A G G
*

* * U
C A
G
G
berikatan membentuk *GA G C
*

G C Hydrogen
suatu lengkungan (loop) U A bonds
* G
A
* A
C
* U
A G
A

Figure 17.14a Anticodon


5 Amino acid
attachment site
3

Hydrogen
bonds

A A G

3 5
Anticodon
Anticodon
(c) Symbol used
in this book
(b) Three-dimensional structure
3. RNA ribosom (RNAr)
a. komponen pembentuk ribosom
b. dihasilkan dari gen khusus (daerah pengatur
nukleolus) pada kromatin
4. small nuclear RNA 5
RNA transcript (pre-mRNA)

(RNAsn) Exon 1 Intron Exon 2

Protein
a. berfungsi 1
snRNA Other proteins

membentuk snRNPs
Spliceosome
spliceosomes, yang
berperan dalam 2 5

memotong dan
membuang
Spliceosome
noncoding sequens components
Cut-out
(intron) dari gen inti 3
5
mRNA
intron

Exon 1 Exon 2
Ribosom
The ribosome has three binding sites for tRNA
The P site P site (Peptidyl-tRNA
binding site)
A site (Aminoacyl-
The A site E site
tRNA binding site)

The E site (Exit site)


Large
subunit
E P A

mRNA
binding site Small
subunit

(b) Schematic model showing binding sites. A ribosome has an mRNA binding site
and three tRNA binding sites, known as the A, P, and E sites. This schematic
Figure 17.16b ribosome will appear in later diagrams.
Amino end Growing polypeptide

Next amino acid


to be added to
polypeptide chain

tRNA

mRNA 3

Codons
5

(c) Schematic model with mRNA and tRNA. A tRNA fits into a binding site when its anticodon base-pairs
with an mRNA codon. The P site holds the tRNA attached to the growing polypeptide. The A site holds
the tRNA carrying the next amino acid to be added to the polypeptide chain. Discharged tRNA leaves via
the E site.
Perbandingan Ribosom
Prokariotik Eukariotik
Kode genetik
Second mRNA base
U C A G
UUU UCU UAU UGU U
Phe Tyr Cys Kodon
UUC UCC UAC UGC C
U Ser
UUA UCA UAA Stop UGA Stop A nonsense
Leu UAG Stop (terninator)
UUG UCG UGG Trp G

Third mRNA base (3 end)


CUU CCU U
First mRNA base (5 end)

CAU CGU
His
CUC CCC CAC CGC C
C Leu Pro Arg
CUA CCA CAA CGA A
Gln
CUG CCG CAG CGG G
AUU ACU AAU AGU U
Asn Ser
AUC lle ACC AAC AGC C
A Thr
AUA ACA AAA AGA A
Met or Lys Arg
Kodon Awal AUG start ACG AAG AGG G
(Promotor) GUU GCU GAU GGU U
GUC GCC GAC Asp GGC C
G Val Ala Gly
GUA GCA GAA GGA A
Glu
GUG GCG GAG GGG G