SIGIT WIDYATMOKO
FAKULTAS KEDOKTERAN
UNIVERSITAS MUHAMMADIYAH SURAKARTA
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Definisi
6. Eating food or drinking beverages that handled by a person carrying the bacteria.
Gram negatif
Enterobacteriaceae
Batang pendek
Kebanyakan berflagella
Tidak berspora
Tidak berkapsul
Penyebaran tifoid di Dunia
Patofisiologi
Air/makanan terkontaminasi
kuman
Sebagian dimusnahkan di
dalam lambung
Perkembangan limfonodi
meningkat Perforasi
Gejala Klinis
Setelah Masa inkubasi = 10-14 hari
Gejala klinis
Typhoid State
When typhoid fever continues untreated for more than two or three
weeks, the effected individual may be delirious or unable to stand and
move, and the eyes may be partially open during this time. At this point
fatal complications may emerge.
Diagnosis
Clinical examination
Blood, bone marrow, or stool
cultures for S. typhi
Serological Tests
Serodiagnosis of Typhoid :
1.Detection of Antibodies in serum:
1.Widal test (Tube or Slide), 2.Typhidot assay
3. Tubex system 4. Dipstick assay.
2. Detection of Antigens in serum:
1. Tubex system 2. Countercurrent
Immunoelectrophoresis (CIE).
3. Co-agglutination test. 4. ELISA
3. Detection of Antigens in urine:
1.Tubex system 2. CIE,
3. Latex agglutination 4. Co-agglutination
Pemeriksaan laboratorium
Pemeriksaan rutin
Darah perifer lengkap: paling sering
leukopeni, dapat normal atau
leukositosis
Anemia ringan
Trombositopenia
LED meningkat
SGOT dan SGPT meningkat
Uji Widal
Deteksi antibodi dasarnya rx silang
antara antigen S.typhi dengan
antibodi aglutinin
Aglutinin O = badan kuman, H= flagel
kuman, Vi = simpai kuman
Uji Tubex
Uji semikuantitatif kolorimetrik yang cepat
(menit)
Mendeteksi antibodi anti-S.typhi 09
Dapat mendeteksi penyakit secara dini (hari
ke 4-5 )
Sensitifitas dan spesifisitas kuat
Activity
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