2010

ageLOC Science
year in review
HIGHLIGHTS
from the Year
Nu Skin
Nu scientist
Skin Remona
scientist Gopaul
Helen accepts
Knaggs,
Nu Skin scientists Scott Ferguson and Steve
Nu
Young Skin
Ph.D.,
Wood, and
Scientist
speaks
Ph.D., LifeGen
ofat
the
and LifeGen present
Year Tom at
Award
In-Cosmetics
Partner from
Prolla,
the Society
CoLONGY
Ph.D., speak of
at Cosmetic
1in
st World Chemists
Barcelona,
Congress
Asia in Bangkok, Thailand Spain
on in
New York Mitochondria
Targeting City, USA in Berlin, Germany

Berlin, Germany

Barcelona, Spain
New York City, USA

Bangkok, Thailand
ageLOC Science
2010 Timeline
 Presented
Published
Nutritional
Article in JournalResearch
of
Conducted at Oxygen
Cosmetic Club of
Science
First pre-clinical California 2010
Published
study on ageLOC Article in Journal
World of
Congress
Submitted
2 Presentations Presented
Published
Cosmetic Dermatology
Completed
Presented Awarded
Provisional
at First Patent
World Congress at CoLONGY
Sponsored
Article in Anti-Aging
First heatmap
Research at validating
Society for DSM
University Nutraceutical
of Tokyo
on
on ageLOC
TargetingVitality
Mitochondria Conference
Medical News
ageLOC nutritional
Investigative science
Dermatology Research
Science SymposiumAward

JANUARY
JULY
OCTOBER
APRIL FEBRUARY
AUGUST
MAY
NOVEMBER MARCH
JUNE
DECEMBER
SEPTEMBER

Presented
Appointed
Published Initiated
Presented Presented
Presented
Launched Presented Awarded
Dr.
Presented
Article
StuartinKim
4Cosmetics
Studies
to at Full-scale
Research at
clinical
Biology
trialof arNOX Research
at New
Research Yorkatat40th
International
First ageLOC Nutrition at In-Cosmetics Young Scientist
Federation of Societies ofofthe
Experimental
Nuand
Skin
ProductageLOC Biology
Toiletries
Anti-Aging 10
Vitality on
International
Aging
ageLOC
Asia GordonVitality
Coenzyme
Research
Conference Society
Annual
Year by European
of Cosmetic
Society of
Cosmetic Chemists
Scientific Advisory Board Q Association Meeting
Conference Cosmeticfor
Chemists
Society Meeting
Chemists
Presented Presented
Youth
Dermatological
Presented
Gene Cluster Research
at Asian Cosmetic Presented
Research
arNOX Research
at International Federation at of
Chemistry Society at Society of Cosmetic
Oxygen
Societies Club
of Cosmetic
Chemists Annual of Chemists
California
Meeting
2010 World Congress
Presented
at University of Tokyo
Science Symposium
ageLOC Science
Publications and
Presentations
 FULL LIST

Posters
Oral Presentations
Patent Submission Awards Journal Articles
March 2010 August 2010
Antioxidation
May
March 2010and lifespan-extension activities of
2010 AntioxidationNovemberAngela
activities Mastaloudis,
of CordyMax
2010 in an oxidative stress July 2010 Biomakers of Mitochondrial Aging and
Transcriptional
CordyMax in oxidative stress and aging models #A177.
Resveratrol
Provisional mimics caloric
Patent
Oxidants and Antioxidants
on Vitalityrestriction
in Biology, andofretards
Oxygen Club A nutritional strategy to oppose the genetic Reducing
model: a mechanismSeniorof its anti-aging
Scientist,properties,
ReceivedAbstract Modulation byWhyskinDostress
Cordyceps People
Sinensis Look
Cs-4.Younger
response Gordon for
#311. Experimental Biology 10, April 24-28, 2010 Conference, Les Diblerets, Switzerland, August 21-27,
aging
# in World
California the heart.
01336-36004, ORAL
Congress,Oxidents and antioxidants
FORMULATIONS
March 17-20, 2010, Santa in Anaheim, CA.expression the DSM
Yang, J., Tan,ofN.,
Nutraceutical
aging
Zhao,and loss of
C., Zhang, Y.,vitality.
and
st with willow
Their
bark-derived
Age, Asian salicin,
CosmeticCosmetics
1 2010. Wood, S.M., Barger, J., Prolla, T. A., Weindruch, R.,
FOR COUNTERACTING EFFECTS
biology, Oxygen Club of California World Congress,
Barbara, CA. Zhu, J., Zhang, Y., Yang, J., Tan, N., Zhao, Zhu, J. S. Research Award
World Congress on Targeting Mitochondria, and Toiletries
Chemistry
(July, Society;
2010):
Mastaloudis, A., and Ferguson, S. 32-36.
Singapore,
Gopaul, R.,
C.,
OF and
March Mastaloudis,
AGING. 2010,A. (presenter;
17-20,Submitted Santa received
MayBarbara,
24, 2010. DSM Prolla, T.
CA. Strategies, Innovation and Clinical Knaggs,China,H., andHelen
Langerveld,
Knaggs.A.
Research Award)
Barger, J.L., Mastaloudis, A., Prolla, T. A., May 2010 Remona Gopaul, Associate
Applications, Berlin, Germany, November 18- September 2010
Weindruch, R., and(arNOX)
Wood,Implicated
S.M. in Appearance 19, Senior
in Japanese Scientist,
Women Named
Correlates with Age- S. B., Appearance December
in Japanese 2010
Age-Related Oxidase 2010. Wood,
Aging and Genesthe Link with Skin. New York Related NADH Oxidase Levels and Blood Markers of S. M., Ferguson, September 2010 Women Correlates with the
Young Scientist of the Presence A Review of CurrentBothGenomic
Aging-Related Oxidative Damage to Skin
Society of Cosmetic Barger, J. L., Prolla, T. A., Weindruch, R., Impact of Scientific Lysolipids,
of Inosotides and Innovations onSignificant
the
Proteins,Oxygen Club of Chemists Meeting,
California, 2010 World Helen Knaggs.
Lipid Oxidation, Society for Investigative Dermatology; J.
Year by the Society of Techniques
Inhibitors of Age-Related Used
NADH in
OxidaseGene
Levels, 40th
and Bartlett, M.
Invest Dermatol 130. S. 6 (2010). Morr, D. J., Morr, D. Personal
Annual European Care Industry, Journal
Society forProfiling
Dermatological of Cosmetic
Congress, Santa Barbara, California. Morr, D. M., Morr, Expression of theResearch,
Skin,
D. J., Meadows, C., Draelos, Z., and M., Kern, D. G., and Cosmetic
Wood, S. M.Chemists Science,
June 9(3)D.2010;
2010. Morr, 260-263.
J., Morr, Knaggs,
D. M., Kern, D. G., H.
Wood,
June
Kern, D.2010
G. Targeting age-related gene expression S. M., Toyoda,Society of Cosmetic
H., and Knaggs, H. Chemists
Transcriptional Biomarkers of Mitochondrial AgingRegulating and improves
the Expressionmental and
of Genes physicalwith
Associated vitality.
the 1st Annual Meeting; New York, New
An evaluation of the effect of a topical
York,ofRemona
SuperoxideGopaul.
April 2010
Modulation by Cordyceps Sinensis Cs-4. Gordon Synthesis andWorld Congress on Targeting
Hyaluronan Mitochondria,
Maintenance of Dermal and Anti-Aging Effects Reduction in Skin by the
CordyMax extends the lifespan in an aging model: a Barrier Lipids Strategies,
Via Topical Treatment of SalicinAn In product containing salicin
Conference, Les Diblerets, Switzerland, August
preliminary report, Abstract #A310. Experimental Biology
21-27, Innovation and Clinical Application of Specific Inhibitors of Age-Related NADH
2010. Vitro Analysis, Society for Investigative Dermatology; J.
Applications, Berlin, Germany, November 18- on the
Oxidase visibleInternational
(arNOX), signs of human skinof aging,
Federation Societies of
10, AprilWood, S.M.,Anaheim,
24-28, 2010 Barger,CA. J.,Tan,
Prolla, T. A., Y.,
N., Zhang, Weindruch,
Invest Dermatol 130. S. 84 (2010). Gopaul, R. and Cosmetic
Journal Chemists,
of Buenos Dermatology,
Cosmetic Aires, Argentina. 9(3)
Kern, 2010;
D. G.,
R., Mastaloudis,
Yang, J., Zhao, C., andA.,Zhu,
andJ.Ferguson,
S. S. Knaggs, H. 19, 2010. Ferguson, S. B., Tan, N., Dong, Y., Meadows, C., Fuller, B. B., Knaggs, H., Morr, D. M., and
Lu, J., Fisk, N.A., Wood, S.M., Zhu, J., andMorr, D. J. 196-201. Gopaul, R., Gibson, M., Knaggs,
Improvement of exercise metabolism and carotenoid H., Holley, K.C., and Lephard, J.
Salicin Bartlett,
Regulates M.
the Expression of Functional Youth
September 2010
antioxidant scores with CordyMax and LifePak in young
Gene Clusters to Reflect a More Youthful Skin Profile,
Chinese elite athletes, Salicin Reduces the Expression of Genes Associated with
Mitochondria and Abstract
Aging.#D356.
Japan Experimental
Symposium. Genes and
International Federation Aging: ofLinks
of Societies to Skin,
Cosmetic
Biology 10, April 24-28, 2010 Anaheim, CA. Duan, L., SkinDecember
InflammationAn
2010In Vitro Analysis, Society for
Mechanisms of Ageing
Zhao, L., Liang, C., andL.,Development
Lu, L., Gao, Li, G., and Zhu, 2010;13:449-
J.S. Chemists Annual Meeting, Buenos Aires, Argentina.
In-Cosmetics Asia; Bangkok, Thailand, Investigative Dermatology; J. Invest Dermatol 130. S. 85
450;480-486. Prolla, T. Gopaul, R., Langerveld, A., Knaggs, H., and Lephart, J. Nutritional and genetic strategies for
(2010). Gopaul, R. and Knaggs, H.
Helen Knaggs. longevity. Anti-Aging Medical News. Winter
Maturational alteration of differential expressions
of GC:AT-biased genotypes of Cordyceps sinensis fungi Inhibition by Coenzyme Q10 of Age Related Oxidase 2010:36-40. Bartlett, M.
and Paecilomyces hepiali in Cordyceps sinensis, Abstract (arNOX) Caused Oxidative Damage in Skin Proteins,
#B210. Experimental Biology 10, April 24-28, 2010 International Coenzyme Q Association Meeting, Brussels,
Anaheim, CA. Zhu, J. S., Gao, L., Yao, Y., and Zhou, Y. Belgium. Morr, D. M., Morr, D. J., Meadows, C.,
Draelos, Z., and Kern, D. G.
summary
Nu Skin scientists and our scientific partners have just concluded a
breakthrough year, building our body of knowledge in anti-aging research at an
accelerating rate with more than 20 presentations at 11 prestigious conferences
and symposia around the world.

We believe Nu Skins ongoing research, combined with our research

partnerships, including LifeGen Technologies, will deepen the companys
understanding of gene expression and its impact on reversing the effects of
aging even later in life.

We believe ageLOC science is the answer to anti-aging. Its a scientific

breakthrough that goes beyond the signs to target the ultimate sources of aging.

For more information about ageLOC science, please visit ageloc.com.