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Vasopressin also called anti diuretic hormone or ADH.

ADH is an important part of regulation in the
Circulatory System and is integral to the balance of
water in the body.
Subtypes of Vasopressin Receptors :
V1a, V2, V3(V1b)
All three are G-protein coupled receptor.

(Jagadesh JS, Muthiah NS, Muniappan M. 2014. Vasopressin Receptors and Drugs: A Brief
Perspective. Global Journal of Pharmacology 8 (1): 80-83, 2014.)

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 Mechanism Of Action :
Vasopressin is a non-adrenergic peripheral
vasoconstrictor by directly stimulating smooth muscle
V1 receptors without increase of myocardial oxygen
consumption because it has no B-adrenergic activity
Indications :
Alternative vasopressor to epinephrine for the treatment of shock-
Refractory VF in adults
A systole or pulseless electrical activity
Refractory cardiac arrest after treatment with epinephrine
Septic shock and sepsis syndrome

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 Dose :
Shock-Refractory VF/pulseless VT
40 U IV, single dose, 1 time only
As a Class Indeterminate action, it is acceptable to resume
epinephrine
1 mg IV push every 3 to 5 minutes if there was no response
in 5 to 10 minutes to a single IV dose of vasopressin.

Precautions
Skin pallor
Nausea
Intestinal cramps
Bronchial constriction
Uterine contractions in women
TERIMA KASIH