of Viral Infection
and Respiratory Related Diseases
Sumardi
Pulmonary Division
Internal Medicine Departement
GMU School of Medicine
Sardjito General Hospital
INTRODUCTION
NEW EMERGING DISEASE
HIV/AIDS
BIRD FLU (Influenza A subtype H5N1)
SWINE ORIGIN INFLUENZA INFECTION H1N1 (SOIV)
WILDTYPE POLIO
EBOLA, ETC
HISTORY
influenza virusanimal origin
humans began to domesticate animals infection on
humansearly as 2000 B.C.
Hippocratesepidemic withflu-like symptoms (412 B.C)
Livy in ancient Romesimilar outbreak of a sudden
malady
Types of viral influenza
A,B and C
Subtype depent on
surface antigen
hemaglutinins (H) 16
neuraminidases (N) 9
Spanish Flu type A,
subtype H1N1 (1918)
influenza A (H3N2) virus
pandemic (1968)
Bird Flu type A,
subtype H5N1 (1997)
Viral Transmission
highly contagious viral diseasespread very
efficiently
person-to-personcoughing and sneezing
boarding schools
households
offices
medical settings
cruise ships
nursing homes
prisons
semi-closed or closed populations
Incubation
1-4 days with an average of 2 days
Adultsinfectiousday before symptoms
begin 5 days after illness onset
3050 % of infected personsasymptomatic
Severely immunocompromised persons can
shed virus for weeks or months.
Signs and symptoms
Sumardi
Tim Penanggulangan Flu Burung/Flu H1N1
RSUP Dr. Sardjito
YOGYAKARTA
WHAT FLU H1N1
MUTATION?
REASSORTMENT?
H1N1 1918?
INTERACTION
PIG/HUMAN/
BIRDS?
CLINICALLY of Flu H1N1
INFLUENZA LIKE ILLNESS (ILI)
FEVER>380 C
COUGH
ODYNOPHAGY
MYALGIA
CEPHALGIA
MALAISE
NAUSEA,VOMITE,DIARHOE
THANK YOU