HYPERLIPIDEMIA
Kadar cholesterol dalam plasma darah
melebihi harga normal.
Cholesterol-LD
- Tanpa PJK, < 2 Faktor Risiko < 160 mg/dL
- - Tanpa PJK, 2 atau lebih Faktor < 130 mg/dL
Risiko < 100 mg/dL
- - Dengan PJK
Cholesterol-HDL
- - Wanita > 45 mg/dL
- - Pria > 35 mg/dL
HMG-KoA Rdktase
Inhibtr(Simvastatin
,dll)
Resin
(Cholestiramin,
Cholestipol)
Fibrate
(Gemfibrozil,
Clofibrate, dll)
Nicotinic Acid
Probucol
Factors induces Hyperlipidemia:
Drugs induce: Disease induce:
Beta Blocker Genetic /primary/fa-
Corticosteroid milial hypercholes
Thiazid diuretic
terolemia
Scondary to liver
Retinoid
disease, renal
Oral Contrasep
failure,
tive contain hypothyroidism, DM
levonorgestrel tak terkontrol
Konseling
Life Style Modification Low Fat Diet,
Stop smooking,Weight reduction,In-
crease physical activity,Reduce alcohol
Liver Function Test: Periodically
STATIN:
Minum di malam hari,kecuali atorvastatin
ADR: Myopati nyeri & lemah otot yg tak
tahu sebabnya segera lapor provider
Keluhan Px: Pusing, mual & nyeri abdomi-
nal yg sembuh stlh obat diteruskan
Pakai statin hrs di+i Life Style Modification
Konseling
FIBRATE:
Dapat sebabkan Myopati segera lapor
ADR: rash,urticaria,weight gain,impotence,
headache
RESIN ION EXCHANGE:
Interaksi Obat: Obat lain 1 jam sebelum /
4-6 jam sesudah Resin
Peningkatan dosis bertahap; dpt dicampur
dg juice buah atau saus makanan
ADR: konstipasi; Mual,muntah, diare,
flatulen,perut tak nyaman hilang sendiri