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Budi Raharjo

HYPERLIPIDEMIA
Kadar cholesterol dalam plasma darah
melebihi harga normal.

KOMPLIKASI KRONIS HIPERLIPIDEMIA:


# Diabetes Mellitus Chol.-LDL Risiko
Hiperglikemia
# ATEROSCHLEROSIS
@ HIPERTENSI
@ Ischemic Heart Disease (IHD)
@ Acute Myocard Infarc (AMI)
@ Cerebro Vasculer Accident (CVA)/STROKE
# Chronic Liver Disease Pancreatitis, Cholestasis,
Hyperbilirubinemia, dll.
KADAR CHOLESTEROL & TRIGLISERIDA IDEAL DEWASA

Cholesterol Total < 200 mg/dL

Cholesterol-LD
- Tanpa PJK, < 2 Faktor Risiko < 160 mg/dL
- - Tanpa PJK, 2 atau lebih Faktor < 130 mg/dL
Risiko < 100 mg/dL
- - Dengan PJK
Cholesterol-HDL
- - Wanita > 45 mg/dL
- - Pria > 35 mg/dL

Trigliserida Total 60160


- Untuk mencegah pankreatitis mg/dL
< 500 mg/dL
1. PENINGKATAN USIA
2. RIWAYAT P.J.K. PREMATUR DALAM
KELUARGA
3. MEROKOK
4. HIPERTENSI
5. DIABETES MELLITUS
6. OVERWEIGHT/OBESITAS
7. INAKTIVITAS/KURANG OLAH RAGA
8. CHOLESTEROL-L.D.L. TINGGI
9. CHOLESTEROL-H.D.L. RENDAH
Golongan Lipid Profile
Obat Tot.Chol Chol-LDL Chol-HDL T.G.
.

HMG-KoA Rdktase

Inhibtr(Simvastatin
,dll)
Resin

(Cholestiramin,
Cholestipol)
Fibrate

(Gemfibrozil,
Clofibrate, dll)
Nicotinic Acid

Probucol
Factors induces Hyperlipidemia:
Drugs induce: Disease induce:
Beta Blocker Genetic /primary/fa-
Corticosteroid milial hypercholes
Thiazid diuretic
terolemia
Scondary to liver
Retinoid
disease, renal
Oral Contrasep
failure,
tive contain hypothyroidism, DM
levonorgestrel tak terkontrol
Konseling
Life Style Modification Low Fat Diet,
Stop smooking,Weight reduction,In-
crease physical activity,Reduce alcohol
Liver Function Test: Periodically
STATIN:
Minum di malam hari,kecuali atorvastatin
ADR: Myopati nyeri & lemah otot yg tak
tahu sebabnya segera lapor provider
Keluhan Px: Pusing, mual & nyeri abdomi-
nal yg sembuh stlh obat diteruskan
Pakai statin hrs di+i Life Style Modification
Konseling
FIBRATE:
Dapat sebabkan Myopati segera lapor
ADR: rash,urticaria,weight gain,impotence,
headache
RESIN ION EXCHANGE:
Interaksi Obat: Obat lain 1 jam sebelum /
4-6 jam sesudah Resin
Peningkatan dosis bertahap; dpt dicampur
dg juice buah atau saus makanan
ADR: konstipasi; Mual,muntah, diare,
flatulen,perut tak nyaman hilang sendiri