REPRODUCTIVEs
HORMONES
BIOCHEMISTRY DEPARTMENT
Molecular medicine case studies :
Mutations of the FSH and LH
receptors (which have similar
structure)
Primary ovarian failure caused by a
point mutation in the FSH receptor
gene.
Chromosome 2p C to T in nucleotide
566 of exon 7 of the FSH receptor
gene. Alanine to Valine substitution at
residue 189 of the protein.
Pituitary Hormones
Posterior pituitary
Prolactin
Growth Hormone (GH)
Thyroid Stimulating Hormone (TSH)
Adrenocorticotropic Hormone (ACTH)
Follicle-stimulating Hormone (FSH)
Luteinizing Hormone (LH)
PROLACTIN
An Overview
estrogens
GnRH LH+FSH
androgens
Estrogen
Progesterone
Dihydrotestosterone
Testosterone
Ovarian hormones
Steroids
o Estrogens
o Androgens
o Progesterone
Peptides
OVARIAN STEROID HORMONES
Transcription second-messenger
regulated kinase or
factor(TF) receptor kinase
steroid/thyroid hormone/retinoic
PO4-TF acid receptor
nucleus Gene A
cytoplasm
HREs
Protein A
mRNA A
mRNA A
Metabolism
Metabolized to glucuronides and
sulfates
Recycled in enterohepatic circulation
Excreted in the urine
Physiological
Reproductive system
2% free
80% albumin-bound
18% corticosteroid-binding protein
(transcortin) -bound
Physiological
Cyclic changes in the endometrium,
cervix, and vagina
Breasts: supports the secretory function
during lactation
Inhibits LH secretion
Responsible for preparing the reproductive
tract for implantation and the maintenance
of pregnancy
Physiological
OVARIAN PEPTIDE HORMONES
Relaxin
Relaxes pelvic joints
Softens and dilates cervix
Sperm mobility - in males
Inhibin
Selective inhibitory control of FSH
Activin
Selective stimulaton of FSH
Cell differentiation
OVARIAN PEPTIDE HORMONES
Follistatins
Inhibit FSH secretion
Gonadotropin surge attenuating factor
Prevents premature LH surge
POMC hormones
Vasopressin and oxytocin (in
luteal cells)
Intrafollicular Polypeptide
Regulatory Factors