I. Excitability
II. Conductivity
III. Contractility
IV. Rhythmicity
Properties of the cardiac Muscle
I. Excitability (Irritability)
I. Excitability (Irritability):
= the ability of cardiac ms to respond to adequate
stimuli by generating an action potential
followed by a mechanical contraction.
Relation between the action potential
& the mechanical response
■ The mechanical response consists of contraction
(systole) & relaxation (diastole).
■ Duration of contraction:
0.2 sec in arial muscle, &
0.3 sec in ventricular muscle.
Relation between the action potential & the mechanical
response (continued)
■ Diastole begins at the end of the plateau.
■ 2nd rapid repolarization is completed at about the
middle of diastole.
Action potential of different types of cardiac muscle
Action potential of ventricular muscle
■ Ventricular ms has a RMP of –90 mV. ( –85 to –95mV).
■ The trans-membranous AP overshoots to a potential of
( +20mV).
AP of ventricular muscle (continued)
■ Trans-membranous AP of ventricular ms is characterized
by presence of 5 phases.
(continued) 0 3
4
Phase 0 = Rapid depolarization.
■ op fast Na+ channels Na+ influx.
Phase 1 = Rapid repolarization/ 1st rapid repolarization.
■ cls Na+ channels, K+ permeability, w Cl- influx.
Phase 2 = A plateau.
■ op slow Ca2+ channels (slow Ca2+ Na+ channels) Ca2+
influx, w slow op K+ channels.
Phase 3 = Slow repolarization/ 2nd rapid repolarization.
■ cls slow Ca2+ channels, w K+ permeability K+ efflux.
Phase 4 = Complete repolarization.
■ actv Na+ K+ pump 2K+ in/ 3Na+ out.
Excitability changes during the action potential:
■ Passes through 3 periods:
1. Absolute refractory period (ARP)
2. Relative refractory period (RRP)
3. Dangerous period (supranormal period)
Refractory Periods
1. Absolute refractory period (ARP):
■ The excitability of cardiac ms is completely lost
during this period, i.e. doesn’t respond to 2nd stimulus.
■ V. long.
long
■ Occupies the whole period of systole.
■ Corresponds to the period of depolarization (phase 0),
& the first 2 phases of repolarization.
■ Ht can’t be tetanized (continuous contraction), as its
ARP occupies the whole contraction phase.
2. Relative Refractory Period (RRP):
1. Cardiac Innervation:
■ Sympathetic NS excitability.
■ Parasympathetic NS (vagus) excitability.
2. Effect of ions concentration in ECF:
■ Ca2+ excitability.
■ K+ excitability.
3. Physical factors:
■ temperature excitability.
■ temperature excitability.
Factors affecting myocardial excitability (continued)
4. Blood flow:
■ Insufficient bl flow to cardiac ms excitability &
myocardial metabolism for 3 reasons:
(1) lack of O2,
(2) excess accumulation of CO2, &
(3) lack of sufficient food nutrients.
5. Chemical factors (drugs):
■ Digitalis excitability.
Properties of the cardiac Muscle
II. Conductivity
II. Conductivity:
= the ability of cardiac ms fibers to conduct the
cardiac impulses that are initiated in the SA-node
(the pacemaker of the heart).
The direction of the impulse:
■ The impulse is conducted:
1st Atrial spread
■ from SA-node conductive tissue
ventricles.
1. Cardiac Innervation:
■ Sympathetic NS conductivity.
■ Parasympathetic NS (vagus) conductivity.
2. Effect of ions concentration in ECF:
■ Ca2+ conductivity.
■ K+ conductivity.
3. Physical factors:
■ temperature conductivity.
■ temperature conductivity.
Factors affecting myocardial conductivity (continued)
4. Blood flow:
■ Insufficient bl flow to cardiac ms conductivity &
myocardial metabolism for 3 reasons:
(1) lack of O2,
(2) excess accumulation of CO2, &
(3) lack of sufficient food nutrients.
5. Chemical factors (drugs):
■ Digitalis conductivity.
Properties of the cardiac Muscle
III. Contractility
III. Contractility:
1. Cardiac innervation.
2. Oxygen supply.
3. Calcium & potassium ions concentration in ECF.
4. Physical factors.
5. Hormonal & chemical factors (drugs).
6. Mechanical factors.
Factors affecting myocardial contractility (continued)
1. Cardiac Innervation:
■ Sympathetic NS force of contraction.
■ Parasympathetic NS (vagus) atrial force of contraction
w no significant effect on ventricular ms.
Factors affecting myocardial contractility (continued)
2. Oxygen supply:
■ Hypoxia contractility.
3. Calcium & potassium ions concentration in
ECF:
■ Ca2+ contractility.
■ K+ contractility.
4. Physical factors:
■ Warming contractility.
■ Cooling contractility.
Factors affecting myocardial contractility (continued)
6. Mechanical factors:
6-
Pacemaker Prepotential:
♥ ? Due to gradual state of depolarization:
■ Steady in K+ permeability
( K+ efflux), leading to
intracellular negativity.
■ Causing spontaneous leakage
of membrane to Na+ w/out
stimulation. 6-
(-60 mV to -55 mV).
■ Which causes op of voltage
gated transient Ca2+ channels,
leading to some Ca2+ influx.
(-40 mV).
Pacemaker Action potential (AP)
6-
♥ Pacemaker Depolarization:
Opening of long lasting (fast) Ca2+ channels.
More Ca2+ influx till reaching the potential, i.e.
firing level point leading to depolarization.
L Ca2+ K+ out
b. Na+ ions:
■ If in ECF innitiate rhythmicity, but can’t
maintain it.
Factors affecting myocardial rhythmicity:
3. Physical factors:
a. Warming: rhythmicity.
b. Cooling: rhythmicity.
c. Exercise: HR as a result of sympathetic n.
stimulation & vagal inhibition to
SA- node.
d. Endurance-trained athletes: Resting bradycardia
due to high vagal activity.
Factors affecting myocardial rhythmicity:
4. Chemical factors (drugs):
a. Thyroid hormones & catecholamines:
rhythmicity.
b. Ach:
rhythmicity.
c. Hypoxia:
rhythmicity.
Remember:
■ Intrinsic rhythmicity of denervated SA- node is 90
impulses/min, while that of AV- node is 60
impulses/min.