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AMODIAQUINE

AMODIAQUINE

CYP2C8

N-Desethylamodiaquine
POLYMORPHISM CYP2C8
POLIMERFISM ACTIVITY
CYP2C8*2*3*4 DEAC

CONCENTRATION
ENZYME ACTIVITY AQ

METABOLISM
DEAQ MODULATE THE
RISK OF AQ, ADVERSE
EFFECT
AMODIAQUINE POPULATION
DRUGS ENZYME CYP FAMILY POPULATION

CYP2C8*1 WILD TYPE

CYP2C8*2
ZANZIBAR AFRICAN,
AMODIAQUINE
CAUCASIAN
CYP2C8*3

CYP2C8*4