Instrumentation
Chapter 6 in
Introduction to Biomedical
Equipment Technology
Passive Sensor:
Provides it own energy or derives energy
from phenomenon being studied
Thermocouple
Sensor Error Sources
Error:
Difference between measured value
and true value.
5 Categories of Errors:
1. Insertion Error
2. Application Error
3. Characteristic Error
4. Dynamic Error
5. Environmental Error
Insertion Error:
Error occurring when inserting a
sensor
Application Error:
Errors caused by Operator
Characteristic Error:
Errors inherent to Device
Dynamic Error:
Most instruments are calibrated in static
conditions if you are reading a thermistor it
takes time to change its value. If you read
this value to quickly an error will result.
Environmental Error:
Errors caused by environment
heat, humidity
Sensor Terminology
Sensitivity:
Slope of output characteristic curve y/ x;
Minimum input of physical parameter will
create a detectable output change
Blood pressure transducer may have a
sensitivity of 10 uV/V/mmHg so you will see a
10 uV change for every V or mmHg applied to
the system.
Output Output
Input Input
Input
Sensitivity Error
Sensor Terminology
Range = Maximum and Minimum values
of applied parameter that can be
measured.
If an instrument can read up to 200 mmHg
and the actual reading is 250 mmHg then you
have exceeded the range of the instrument.
Sensor Terminology
Dynamic Range: total range of sensor for
minimum to maximum. Ie if your instrument
can measure from -10V to +10 V your dynamic
range is 20V
Precision = Degree of reproducibility denoted
as the range of one standard deviation
Resolution = smallest detectable incremental
change of input parameter that can be
detected
Accuracy
Accuracy = maximum difference that
will exist between the actual value and
the indicated value of the sensor
Xi Xo
Offset Error
Offset error = output that will exist
when it should be zero
The characteristic curve had the same
sensitive slope but had a y intercept
Output Output
Input Input
Offset Error
Zero offset error
Linearity
Output Din(Max)
Input
Hysteresis
Hysteresis = measurement of how sensor
changes with input parameter based on
direction of change
Hysteresis
The value B can be represented by 2 values of F(x), F1
and F2. If you are at point P then you reach B by the
value F2. If you are at point Q then you reach B by
value of F1.
Output = F(x) P
F2
F1 Input = x
B
Q
Response Time
Ton Time
Response Time
Ton Time
Response Time
Tdecay
F(t)
Decaying Response Time
Toff Time
Output Output
F(x) F(x)
K K
Input X Input X
Dynamic Linearity
Asymmetric = F(x) != |F(-x)| where F(x)* is
asymmetric around linear curve F(x) then
F(x) = ax + bx2+cx4+ . . . +K offsetting for K or
you could assume K = 0
Symmetrical = F(x) = |F(-x)| where F(x) * is
symmetric around linear curve F(x) then
F(x) = ax +bx3 + cx5 +. . . + K offsetting for K or
you could assume K =0
Frequency Response of Ideal
and Practical System
When you look at the frequency response of an instrument,
ideally you want a wideband flat frequency response.
Av Av = Vo/Vi
1.0
FL FH
Frequency (w) radians per second
3 Types of electrodes:
Surface (in vivo) outside body
Indwelling Macroelectrodes (in vivo)
Microelectrodes (in vitro) inside body
Bioelectrodes
Electrode Potentials:
Skin is electrolytic and can be modeled as
electrolytic solutions
Metal
Electrode
Electrolytic Solution
Electrodes
If metals are different you will have differential
potential sometimes called an electrode offset
potential.
Metal A = gold Vae = 1.50V and Metal B = silver
Vbe = 0.8V then Vab = 1.5V 0.8 V = 0.7V (Table
6-1 in book page 96)
Electrolytic Solution
Electrodes
Two general categories of material
combinations:
Perfectly polarized or perfectly
nonreversible electrode: no net transfer of
charge across metal/electrolyte interface
Perfectly Nonpolarized or perfectly
reversible electrode: unhindered transfer
of charge between metal electrode and the
electrode
Generally select a reversible electrode such as
Ag-AgCl (silver-silver chloride)
Electrode A C1a Vea
- +
Cellular Rsa R1a
Resistance
Rc
Mass
Rt - Vo
Cellular Tissue Vd +
Potentials Resistance
Electrode B
C1b
Veb
- +
Rsb
R1b
Binding Spot
Pin-Tip
Connector Shielded Wire
Electrode Surface
Medical Surface Electrodes
Have an Ag-AgCl contact button at top of
hollow column filled with gel
Gel filled column holds actual metallic
electrode off surface of skin and decreases
movement artifact
Typical ECG arrangement is to have 3 ECG
electrodes (2 differentials signals and a
reference electrode)
Problems with Surface
Electrodes
1. Adhesive does not stick for a long time on
sweaty skin
2. Can not put electrode on bony prominences
3. Movement or motion artifact significant
problem with long term monitoring results in
a gross change in potential
4. Electrode slippage if electrode slips then
thickness of jelly changes abruptly which is
reflected as a change in electrode
impedance and electrode offset potential
(slight change in potential)
Potential Solutions for Surface
Electrodes Problems
1. Additional Tape
2. Rough surface electrode that digs past scaly
outer layer of skin typically not comfortable for
patients.
Other Types of Electrodes
Needle Electrodes: inserted into tissue
immediately beneath skin by puncturing skin on an
angle note infection is a problem.
Indwelling Electrodes: Inserted into layers
beneath skin -> typically tiny exposed metallic
contact at end of catheter usually threaded
through patients vein to measure intracardiac
ECG to measure high frequency characteristics
such as signal at the bundle of His
Other Types of Electrodes
EEG Electrodes: can be a needle electrode but
usually a 1 cm diameter concave disc of gold or
silver and is held in place by a thick paste that is
highly conductive sometimes secured by a
headband
Microelectrode
Microelectrode: measure biopotential at
cellular level where microelectrode
penetrates cell that immersed in an
infinite fluid
Saline.
Microelectrode
R1 RS = Spreading Resistance
of the electrode and is
RS a function of tip
C1 C2
Vo diameter
V1 R1 and C1 are result of the
effects of
electrode/cell interface
C2 = Electrode Capacitance
Calculation for Resistance Rs
Rs in metallic microelectrodes
without glass coating:
where Rs = resistance ohms
P ()
Rs P = Resistivity of the infinite
4r
solution outside electrode =
70cm 70 cm for physiological
Rs
43.14 0.5 *10-4 cm saline
r = tip radius ( ~0.5 um for 1
111.4 K um electrode) = 0.5 x10-4
cm
Calculation for Resistance Rs
Rs of glass coated metallic
microelectrode is 1-2 order of magnitude
higher:
where Rs = resistance
2P ohms ()
Rs
r P = Resistivity of the
infintie solution outside
23.7cm electrode) = 3.7 cm for 3
3.140.1 * 10-4 cm 3.14 180
Rs
M KCl
r = tip radius typically 0.1 u
13.5M m = 0.1 x 10-4 cm
= taper angle (~ / 180)
Capacitance of Microelectrode
Capacitance of C2 has units pF/cm
C2
0.55e
R
ln
r
C2
0.55e
(0.55)( 4)
7.7
pF
R 0.2 m cm
ln ln
r 0.15m
Transducers and other Sensors
EC
+ Eo - ED
Es + EC + Eo - ED
-
R2 R4
R4
R2 B
Basic Wheatstone Bridge uses one resistor in
each of four arms where battery excites the
bridge connected across 2 opposite resistor
junctions (A and B). The bridge output Eo
appears across C and D junction.
Finding output voltage to a
Wheatstone Bridge
Ex: A wheatstone bridge is excited by a 12V dc source
and has the following resistances R1 = 1.2K R2 = 3 K
R3 = 2.2 K ; and R4 = 5 K ; find Eo
R2 R4
Eo Es -
R1 + R 2 R 3 + R4
3 * 10 3 5 * 10 3
Eo 12V -
1.2 * 10 + 3 * 10
3 3
2.2 * 10 3 + 5 * 10 3
3 5
Eo 12V - 0.24V
4.2 7.2
Finding output voltage to a
Wheatstone Bridge
Eo EC - ED
R2
EC Es
R1 + R 2
R4
ED Es
R 3 + R 4
R2 R4
Eo Es -
R1 + R 2 R 3 + R4
3 * 10 3 5 * 10 3
Eo 12V -
1.2 * 10 + 3 * 10 2.2 * 10 + 5 * 10
3 3 3 3
3 5
Eo 12V - 0.24V
4.2 7.2
Null Condition of Wheatstone Bridge
L - DL = length Compression
Strain Gauges
Tension = increase in length by DL and a
decrease in cross section area.
L = length Rest Condition
L + DL = length Tension
Resistance of a metallic bar is
given in length and area
pL
R
A
where
R = Resistance units = ohms ()
= resistivity constant unique to type of
material used in bar units = ohm meter (m)
L = length in meters (m)
A = Cross sectional area in meters2 (m2 )
Resistance of a metallic bar is
given in length and area
Example: find the resistance of a copper bar that has a cross
sectional area of 0.5 mm2 and a length = 250 mm note the resistivity
of copper is 1.7 x 10-8m
250mm 1m
L 1000mm 0.0085
R 1.7 *10-8 m 2
A
0.5mm2 1m
1000 mm
Piezoresistivity
Piezoresistivity = change in resistance for a
given change in size and shape denoted as h
L + DL
Resistance in tension = R + h
A - DA
Note: Textbook forgot the in equations 6-28 and 6-29 on page 110
Example of Piezoresistivity
DR
GF R
DL
L
where
GF = Gauge Factor unitless
R = change in resistance ohms ()
R = unstrained resistance ohms ()
L = change in length meters (m)
L = unstrained length meters (m)
Gauge Factor
DR
GF R
DL L
Where strain which is unitless
GF gives relative sensitivity of a strain gauge where the
greater the change in resistance per unit length the
greater the sensitivity of element and the greater the
gauge factor.
Example of Gauge Factor
Have a 20 mm length of wire used as a string gauge
and has a resistance of 150 .
When a force is applied in tension the resistance
changes by 2 and the length changes by 0.07 mm.
Find the gauge factor:
DR 2
GF R
150 3.71
DL 0.07mm
L 20mm
Types of Strain Gauges: Unbonded and
Bonded
ES + C
Vo
D
-
R4 = SG4
R2 = SG2 B
Circuit Derivation:
A R 2 R 4
Eo Es -
R1 = R +h R3= R-h R1 + R 2 R 3 + R 4
Es
Eo Es
R - h
-
R + h
C +
- R + h + R - h R - h + R + h
+ Eo
D
-
R - h R + h - 2h h
Eo Es - Es - Es
2R 2 R 2 R R
R2 = R - h R4 = R +h
B 10
Eo -10V -0.5V
200
Note: Text book has wrongly stated that tension decreases R and compression increases R on page 112
Transducer Sensitivity
Transducer Sensitivity = rating that
allows us to predict the output voltage
from knowledge of the excitation
voltage and the value of the applied
stimulus units = V/V*unit of applied
stimulus
Transducer Sensitivity
Example if you have a force transducer calibrated in
grams (unit of mass) which allows calibration of force
transducer then sensitivity denoted as = V/V*g
(another ex = V/V*mmHg)
Transducer Sensitivity
To calculate Output Potential use the
following equations:
Eo * E * F
where
Eo = output potential in Volts (V)
E = excitation voltage
= sensitivity V/V*g
F = applied force in grams (g)
Transducer Sensitivity
Example: Transducer has a sensitivity of 10 V/V*g,
predict the output voltage for an applied force of 15 g
and 5 V of excitation.
10V
Eo EF 5V 15 g 750V
Vg
note book has typo where writes V/V/g for sensitivity
Inductance Transducers
Inductance Transducers: inductance L can
be varied easily by physical movement of a
permeable core within an inductor 3 basic
forms:
Single Coil
Reactive Wheatstone Bridge
Linear Voltage Differential Transformer LVDT:
LVDT:
Diaphragm
L2
AC Excitation L1
Core
External
L3 Load
Axis of Motion
Capacitance Transducers
Quartz Pressure Sensors: capacitively
based where sensor is made of fused
quartz
Capacitive Transducers: Capacitance C
varies with stimulus
Capacitive Transducers:
Three examples:
Solid Metal disc parallel to flexible metal
diaphragm separated by air or vacuum (similar to
capacitor microphone) when force is applied they
will move closer or further away.
Stationary metal plate and rotating moveable plate:
as you rotate capacitance will increase or decrease
Differential Capacitance: 1 Moveable metal Plate
placed between 2 stationary Places where you
have 2 capacitors: C1 between P1 and P3 and C2
between P2 and P3 where when a force is applied
to diaphragm P3 moves closer to one plate or vice
versa
Temperature Transducers
3 Common Types:
Thermocouples
Thermistors
Solid State PN Junctions
Thermocouple:
1.38 *10 - 23
J / K 37 + 273 K ln
2mA
DVBE 1mA
1.6 *10 -19 Coulombs
DVBE 0.0185V
Homework
Read Chapter 7
Chapter 6 Problems: 1, 3 to 6, 9
Problem 1: resistivity = 1.7 * 10-8m
Problem 4: sensitivity = 50 V/(V*mmHg)
Problem 4: 1 torr = 1 mmHg
Problem 6: sensitivity = 50 V/(V*g)
Review
What are two types of sensors?
List 5 categories of error
How do we quantify sensors?
What is an electrode?
How do you calculate Rs and C2 of a microelectrode that
is metal with and without glass coating?
What is a transducer?
What is a Wheatstone Bridge? How do you derive the
output voltage
Find resistance of a metallic bar for a given length and
area
How does resistance change in tension and in
compression and how do you calculate resistance
Review
How do you find resistance change in piezoresistive
device
How do you determine gauge factor
What is the definition of a strain gauge and what is
difference between bonded and unbonded strain gauge.
Determine the output potential given a transducers
sensitivity.
What are inductance, capacitance, and temperature
transducers?
How do you calculate the temperature for a solid state PN
Junction Diode?