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SUB HEADING IN CALIBRI
SUB HEADING IN CALIBRI

MANAGEMENT of OsteoArthritis and Acute Pain

Osteoarthritis

Osteoarthritis (OA) is a Degenerative joint disease characterized

by the breakdown of the joint's cartilage and hypertrophy of bone and

Articular Margins.
The Pathology of Osteoarthritis

In healthy joints cartilage acts as a shock absorber when you put weight
on the joint

The slippery surface of the cartilage allows the bones to move

smoothly.

In OA the cartilage gradually becomes rough and thin, and the bone
underneath thickens.

Over time the cartilage may wear away entirely, and the bones
will rub together.
What it looks like
Risk Factors for OA
Sign & Symptoms

Pain, especially when moving a joint

Swelling or bumps

Sore and stiff fingers and foot

Grating sound when the roughened cartilage on the surface of the bones
rubs together

Difficulty in certain movement for example walk up the stairs

Clinical Efficacy of Artifen/Diclofenac sodium in
OsteoArthritis
A variety of clinical trials in more than 15,000 patients with
osteoarthritis have shown Diclofenac to be effective and well
tolerated

The results of this review document that Diclofenac is as effective as

non steroidal anti-inflammatory drugs in the treatment of
Osteoarthritis.

1- Ten years of clinical experience. Basle, Switzerland, CIBA-GEIGY Limited, 1981; 39.
2- Roy Altman MD, International Experience with Diclofenac in OsteoArthritis. The American Journal of Medicine Volume 80, 1986
Artifen/Diclofenac sodium in Traumatic Pain

Long Term Studies demonstrate

that effectiveness is maintained
for at least one year after
initiation of therapy.

2- Roy Altman MD, International Experience with Diclofenac in OsteoArthritis. The American Journal of Medicine Volume 80,
1986
Artifen/Diclofenac sodium in OsteoArthritis

Reduction in spontaneous Pain

amounted for 88% after three days
while improvement in edema of
Inflammation reached 95%

Mean Severity of Spontaneous pain (Rated on VAS, 0 to

100) in 50 accident Victims after administration of
Diclofenac

2- Roy Altman MD, International Experience with Diclofenac in OsteoArthritis. The American Journal of Medicine Volume 80, 1986
Renal Colic

Renal colic is a type of abdominal

pain commonly caused by kidney stones.

Renal colic is caused by a blockage in

your urinary tract due to Kidney stones.

Blood clots, ureter spasms, and dead

tissue may also block your urinary tract.
Biliary Colic

Biliary colic is the term used to describe

a type of pain related to the gallbladder
that occurs when a gallstone transiently
obstructs the cystic duct and the
gallbladder contracts.
Management of Renal and Biliary colic

Non-steroidal anti-inflammatory drugs such

as Diclofenac and antispasmodics like
butylscopolamine are used.

Although morphine may be administered to

assist with pain management, it is often not
recommended as morphine raises ureteral
pressure, worsening the condition
 Artifen/Diclofenac Sodium Injection in Renal Colic

Provides Excellent Analgesia in Renal Colic & highly effective but

should be used with care in patients at risk of renal impairment,

cardiac failure and gastric ulceration in reducing number of new colic

episodes & readmissions to hospitals

4- Kim Davenport * and Elizabeth Waine, The Role of Non-Steroidal Anti-Inflammatory Drugs in Renal Colic Pharmaceuticals 2010, 3, 1304-1310;
 Artifen/diclofenac sodium Injection in Biliary Colic

Recommended in all biliary colic attacks & in high risk patients

95 %
85 %

Responded Well Complete Pain Relief

5- EVANGELOS A. AKRIVIADIS et Al. , Treatment of Biliary Colic With Diclofenac: A Randomized, Double-Blind, Placebo-Controlled Study GASTROENTEROLOGY 1997;113:225231
Artifen/Diclofenac Sodium

Artifen is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that exhibits

Anti-inflammatory and Analgesic activity .

75mg/ 3 ml 50 mg
Injection Tablets
Artifen Tablets

Effective and Sustained Analgesic Action up to 12 hours.

Enteric Coating helps in Low incidence of Side effects.

Assures Patient compliance with convenient BD dosing.

Small sized Tablets ensure patient Usage

Artifen Tablets Indications

For relief of the signs and symptoms of Osteoarthritis,

Rheumatoid Arthritis

For acute or long-term use in the relief of signs and symptoms of

Ankylosing Spondylitis.

Also indicated for controlling pain and inflammation in Acute

Gout and minor surgery.

It is also indicated for Chronic Juvenile Arthritis

Artifen Tablets Dosage

For the relief of Osteoarthritis, the recommended Dosage is 100-

150 mg/day in divided doses 50 mg one tablet b.i.d or T.i.d.

For the relief of Rheumatoid Arthritis, the recommended dosage

is 150-200 mg/day in divided doses 50 mg tablet t.i.d or q.i.d.

For the relief of Ankylosing Spondylitis, the recommended dosage

is 100-125 mg/day, administered as 50 mg b.i.d.
Artifen Injection/ Diclofenac Sodium

Artifen Injection provides fast onset of Action with minimal Pain at the
site of Administration and persistent concentration at the site of
Inflammation.
The Artifen Injections are effective in:

Renal colic.
Exacerbations of Osteoarthritis and Rheumatoid arthritis.
Acute back pain.
Acute Trauma and Fractures
Artifen Injection Dosage

One 75mg Ampoule I.M. A further ampoule may be administered

after 30 minutes if necessary.

The recommended maximum daily dose of Artifen is 150mg.

Artifen ampoules are not recommended for use in children

Thank You