Interaksi Obat System Syaraf
Interaksi Obat System Syaraf
Penggolongan
Interaksi obat DI
Change in gastrointestinal pH
Ketoconazole needs acidic conditions in gut
Drug binding in GI tract
E.g. tetracycline/quinolone and calcium
Increases gastric
emptying
Increases
absorption of
analgesic in
treatment of acute
attack of migraine
Interaksi pada fase distribusi
inhibisi dpt terjadi thd reaksi MFO atau jalur metabolisme lain
+ = ??
Enzim Inhibition
20 Control
C learance (ml/min)
Cimetidine
15
10
0
D DZD CZD OXM
20
Renal clearance of salicylate
cle arance (ml/min)
Salicylic acid renal
Kemaknaan/signifikansi interaksi
1 Major Suspected
2 Moderate Suspected
3 Minor Suspected
4 Major/moderate Possible
5 Minor Possible
Penjelasan