Carbohydrates
Glucose Pyruvate
Fatty acids
Fats
Amino acids
TCA Cycle
Krebs
Cycle
Proteins
ATP
Glucose-6-Phosphate (G6P)
The Central Molecule
Glucose Homeostasis
Normal Blood Glucose
Fasting state : 60 to 100 mg%
Postprandial : 100 to 140 mg %
Control systems
Glucose Receptors, GLUT 1-14
Controlling Hormones, Insulin, Glucagon, Cortisol,
Epinephrine etc
Effector Cells Muscles, Liver, Brain, Heart and Adipose
tissue
Feedback loops
Negative feedback
Positive feedback
Glucose Homeostasis
Lower Blood Glucose Between meals
-cells release
Glucagon
stimulate glucose
stimulate glycogen uptake by peripheral
breakdown and tissues
gluconeogenesis
-cells release insulin
Food
Higher Blood Glucose
Blood glucose regulation
When we eat food, our blood glucose
concentration rises, which stimulates insulin
secretion from -cells and eventual glucose
absorption by peripheral tissues.