by Patty Bostwick-Taylor,
Florence-Darlington Technical College
Blood
10
Copyright 2009 Pearson Education, Inc., publishing as Benjamin Cummings
Blood
The only fluid tissue in the human body
Classified as a connective tissue
Components of blood
Living cells
Formed elements
Non-living matrix
Plasma
Figure 10.1 (1 of 2)
Figure 10.1 (2 of 2)
Figure 10.2
Table 10.2 (1 of 2)
Table 10.2 (2 of 2)
Table 10.1
Figure 10.3
Basophils
Erythrocytes
Platelets
Eosinophils
Figure 10.4
Lymphocytes
Lymphocytes
Basophils
Erythrocytes
Platelets
Eosinophils
Figure 10.4
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Increased
O2- carrying
ability of blood
Reduced O2
levels in blood
More
RBCs
Kidney releases
Enhanced erythropoietin
erythropoiesis Erythropoietin
stimulates
Red bone
marrow
Figure 10.5
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Reduced O2
levels in blood
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Reduced O2
levels in blood
Kidney releases
erythropoietin
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Reduced O2
levels in blood
Kidney releases
erythropoietin
Erythropoietin
stimulates
Red bone
marrow
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Reduced O2
levels in blood
More
RBCs
Kidney releases
Enhanced erythropoietin
erythropoiesis Erythropoietin
stimulates
Red bone
marrow
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Increased
O2- carrying
ability of blood
Reduced O2
levels in blood
More
RBCs
Kidney releases
Enhanced erythropoietin
erythropoiesis Erythropoietin
stimulates
Red bone
marrow
Stimulus: Decreased
Normal blood oxygen levels RBC count, decreased
availability of O2 to
blood, or increased
tissue demands for O2
Increased
O2- carrying
ability of blood
Reduced O2
levels in blood
More
RBCs
Kidney releases
Enhanced erythropoietin
erythropoiesis Erythropoietin
stimulates
Red bone
marrow
Figure 10.6
Step 2: Step 3:
Platelet Plug Formation Coagulation
Injury to lining Platelet Fibrin clot with
of vessel exposes plug trapped red
collagen fibers; forms blood cells
platelets adhere
Collagen
Platelets Fibrin
fibers
Platelets release chemicals
that attract more platelets to
the site and make nearby
platelets sticky
PF3 from
platelets Calcium
and other
+ clotting
factors
Tissue factor in blood
in damaged plasma
tissue
Phases of
Formation of
coagulation
prothrombin
(clotting
activator
cascade)
Prothrombin Thrombin
Fibrinogen Fibrin
(soluble) (insoluble)
Figure 10.6
Step 2:
Platelet Plug Formation
Injury to lining
of vessel exposes
collagen fibers;
platelets adhere
Collagen
fibers
Figure 10.6, step 2
Step 2:
Platelet Plug Formation
Injury to lining Platelet
of vessel exposes plug
collagen fibers; forms
platelets adhere
Collagen
fibers Platelets
Figure 10.6, step 3
Step 2:
Platelet Plug Formation
Injury to lining Platelet
of vessel exposes plug
collagen fibers; forms
platelets adhere
Collagen
fibers Platelets
PF3 from
platelets Calcium
and other
+
clotting
factors
Tissue factor in blood
in damaged plasma
tissue
Figure 10.6, step 4
PF3 from
platelets Calcium
and other
+ clotting
factors
in blood
Tissue factor
plasma
in damaged
tissue
Phases of
coagulation Formation of
(clotting prothrombin
cascade) activator
PF3 from
platelets Calcium
and other
+ clotting
factors
in blood
Tissue factor
in damaged plasma
tissue
Phases of
coagulation Formation of
(clotting prothrombin
cascade) activator
Prothrombin Thrombin
PF3 from
platelets Calcium
and other
+ clotting
factors
Tissue factor in blood
in damaged plasma
tissue
Phases of
coagulation Formation of
(clotting prothrombin
cascade) activator
Prothrombin Thrombin
Fibrinogen Fibrin
(soluble) (insoluble)
Figure 10.6, step 7
Step 2: Step 3:
Platelet Plug Formation Coagulation
Injury to lining Platelet Fibrin clot with
of vessel exposes plug trapped red
collagen fibers; forms blood cells
platelets adhere
Collagen
Platelets Fibrin
fibers
Platelets release chemicals
that attract more platelets to
the site and make nearby
platelets sticky
PF3 from
platelets Calcium
and other
+ clotting
factors
Tissue factor in blood
in damaged plasma
tissue
Phases of
Formation of
coagulation
prothrombin
(clotting
activator
cascade)
Prothrombin Thrombin
Fibrinogen Fibrin
(soluble) (insoluble)
Figure 10.7
Table 10.3
Figure 10.8