JURNAL REPORT

BIPOLAR DISORDERS

Preceptor :
dr. Iwan Sys, Sp.KJ

By : 1
Zahrotul Hasanah Harum (201510401011091)
Niqma N. Sanad (201510401011052)

DEPARTEMENT OF PSYCHIATRY
MEDICAL FACULTY
UNIVERSITY OF MUHAMMADIYAH MALANG
2017
 March 1, 2012 ◆ Volume 85, Number 5
www.aafp.org/afp American Family Physician

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 INTRODUCE

 Bipolar disorder are common, disabling, recurrent health conditions of variable

severity
 Onset is often in late childhood or early adolescence.
 Early recognition and treatment of bipolar disorders improve outcomes.

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 DEFINITION
 Bipolar disorders include four subtypes :

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 EPIDEMIOLOGY

 In 2004, the WHO ranked bipolar disorders collectively as the 12th most common
moderately to severely disabling condition in the world for any age group.
 Bipolar disorders have no predilection for race, sex, or ethnicity.
 Although they can occur at any age, bipolar disorders are most common in persons
younger than 25 years .

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 ETIOLOGY

 Children of parents with bipolar disorders have a 4 to 15 percent risk of also

being affected, compared with a 0 to 2 percent risk in children of parents
without bipolar disorders.
 Environmental factors
 These factors include stressful life events, particularly suicide of a family
member; disruptions in the sleep cycle; and family members or caregivers
with high expressed emotion, a communication pattern defined as
emotionally overinvolved, hostile, and critical
 New data have identified several genes and loci that may be associated with
bipolar disorders, including glycogen synthase kinase-3β.

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CRITERIA FOR MANIC EPISODE: DSM-
5

A. A distinct period of abnormally and persistently elevated,

expansive, or irritable mood, lasting at least 1 week (or any
duration if hospitalization is necessary).
B. During the period of mood disturbance, three (or more) of
the following symptoms have persisted (four if the mood is
only irritable) and have been present to a significant degree:
1. inflated self-esteem or grandiosity
2. Decreased need for sleep
3. More talkative than usual or pressure to keep talking
4. Flight of ideas or subjective experience that thoughts
are racing
5. Distractibility (i.e., attention too easily drawn to
unimportant or irrelevant external stimuli)
6. Increase in goal-directed activity (either socially, at
work or school, or sexually) or psychomotor agitation
7. Excessive involvement in pleasurable activities that
have a high potential for painful consequences (e.g.,
engaging in unrestrained buying sprees, sexual
indiscretions, or foolish business investments)
C. The mood disturbance is sufficiently severe to cause marked
impairment in occupational functioning or in usual social activities
or relationships with others, or to necessitate hospitalization to
prevent harm to self or others, or there are psychotic features.
D. The symptoms are not due to the direct physiological effects of
a substance (e.g., a drug of abuse, a medication, or other
treatment) or a general medical condition (e.g., hyperthyroidism).

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental

disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
CRITERIA FOR MAJOR DEPRESSIVE EPISODE:
DSM-5
A. Five (or more) of the following symptoms have been present
during the same 2- week period and represent a change from
previous functioning; at least one of the symptoms is either
(1) depressed mood or (2) loss of interest or pleasure.

1. Depressed mood most of the day, nearly every day, as

indicated by either subjective report (e.g., feels sad or empty)
or observation made by others (e.g., appears tearful)
2. Markedly diminished interest or pleasure in all, or almost all,
activities most of the day, nearly every day
3. Significant weight loss when not dieting or weight gain, or
decrease or increase in appetite nearly every day.
4. Insomnia or hypersomnia nearly every day.
5. Psychomotor agitation or retardation nearly every day
6. Fatigue or loss of energy nearly every day.
7. Feelings of worthlessness or excessive or inappropriate
guilt (which may be delusional) nearly every day (not
merely self-reproach or guilt about being sick).
8. Diminished ability to think or concentrate, or
indecisiveness, nearly every day
9. Recurrent thoughts of death (not just fear of dying),
recurrent suicidal ideation without a specific plan, or a
suicide attempt or a specific plan for committing suicide.
B.The symptoms cause clinically significant distress or
impairment in social, occupational or other important areas
of functioning.
C.The symptoms are not due to the direct physiological
effects of a substance (e.g., a drug of abuse, a medication)
or a general medical condition (e.g., hypothyroidism).

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders
(5th ed.). Arlington, VA: American Psychiatric Publishing.
CRITERIA FOR HYPOMANIC EPISODE:
DSM-5

A. A distinct period of abnormally and persistently elevated,

expansive, or irritable mood and abnormally and persistently
increased activity or energy, lasting at least 4 consecutive days
and present most of the day, nearly every day.
B. During the period of mood disturbance and increased energy and
activity, three (or more) of the following symptoms (four if the
mood is only irritable) have persisted, represent a noticeable
change from usual behavior, and have been present to a significant
degree:

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1. Inflated self-esteem or grandiosity.
2. Decreased need for sleep (e.g., feels rested after only 3
hours of sleep).
3. More talkative than usual or pressure to keep talking.
4. Flight of ideas or subjective experience that thoughts are
racing.
5. Distractibility (i.e., attention too easily drawn to
unimportant or irrelevant external stimuli), as reported
or observed.
6. Increase in goal-directed activity (either socially, at work
or school, or sexually) or psychomotor agitation.
7. Excessive involvement in activities that have a high
potential for painful consequences (e.g., engaging in
unrestrained buying sprees, sexual indiscretions, or
foolish business investments)

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C. The episode is associated with an unequivocal change in functioning
that is uncharacteristic of the individual when not symptomatic.
D. The disturbance in mood and the change in functioning are
observable by others.
E. The episode is not severe enough to cause marked impairment in
social or occupational functioning or to necessitate hospitalization. If
there are psychotic features, the episode is, by definition, manic.
F. The episode is not attributable to the physiological effects of a
substance (e.g., a drug of abuse, a medication, other treatment).

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 TREATMENT
 Early diagnosis and treatment of acute mood episodes improve prognosis by reducing
the risk of relapse.
 Treatment should continue indefinitely because of the risk of relapse, which occurs in
one-third of patients in the first year after presentation and in more than 70% of patiens
within five years.
 Monotherapy with antidepressants is contraindicated in patients with mixed states,
manic episodes, or bipolar I disorder

 Electroconvulsive therapy can be effective for mania and psychotic depression.

 Behavioral interventions (e.g., cognitive behavior therapy, caregiver support) are
considered first-line adjuncts to pharmacotherapy to improve social function and reduce
the need for medications, number of hospitalizations, and relapse rates.

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 Family and Psychosocial Issues

 Psychosocial stress is known to trigger manic and depressive symptoms.

Although there are limited and heterogenous data to support family interventions
for bipolar disorders.
 Patients who have social support in recognizing early warning signs of
reccurence appear to have better functioning
 Patiens who receive intensive psychotherapy have fewer relapses and longer
period of relative wellness compared with patients who receive brief therapy

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