URINARY SYSTEM
Histology Departement
FK USU
August 2008
Urinary System: Kidney, urinary passages
Passages include:
Calyces
Renal Pelvis
Ureter
Accessory parts include:
Urinary bladder
Urethra
Kidney:
Flattened, bean-shaped ~4.5 inches long
Capsule: thin, fibrous, weakly attached (mostly collagenous fibers)
Interstitial C.T. – scant; entirely reticular tissue
Hilus: slit-like orifice – opens into expanded renal sinus, a flattened cavity
Renal sinus filled with: renal pelvis (expanded ureter); fat; C.T.;
blood vessels; nerves
Kidney cross-section
Renal Pelvis:
Subdivided into 2 or 3 major calyces
Major calyces (1) subdivide into 7 – 10 minor calyces (2)
Minor calyces fit over a renal papilla (3)
3
Kidney interior: largely parenchyma
Delicate reticulum replaces trabeculae & other supporting structures
Parenchyma: many long, tortuous secretory canals (nephrons)
Excretory ducts of nephrons discharge into minor calyces
Nephron + excretory duct = uriniferous tubule
Parenchyma divisible into Cortex & Medulla
Medulla (gray when fresh) composed of 10 – 15 renal
pyramids
2 to 3 pyramids fuse: end in one papilla
i.e., 6 to 14 papillae / kidney (human)
Pyramids appear striate (tubules are straight)
Cortex ( brownish in life)
Inner border irregular
Over base of pyramid; between pyramids (Renal
columns of Bertin)
Nephron (Uriniferous Tubule) – Kidney is a compound gland
Uriniferous tubule composed of two parts:
Secretory tubule (nephron) & Collecting tubule
Nephron:
The physiological unit of the kidney used for filtration of blood and
reabsorption and secretion of materials
Unbranched; 35 mm. long
Includes straight portions & convoluted portions
1,300,000 tubules each kidney
Collecting tubules
part of a branched, tree-like system of excretory ducts
tubules are straight
Length: 21 mm. (each)
Nephrons
Parts of the Uriniferous Tubule
Consecutive portions differ structurally & functionally
(proximal means near the glomerulus & distal means nearer the papilla)
The parts starting from the proximal end, taken in order:
The Secretory Portion
Glomerular capsule of Bowman
Proximal Convoluted Tubule (including the
straight portion = thick, descending segment of
Henle’s loop)
Thin segment of Henle’s loop
Thick, ascending segment of Henle’s loop
Distal Convoluted Tubule
The Excretory (= duct) Portion
Arched Collecting Tubule (= junctional tubule)
Straight Collecting Tubule
Papillary Duct of Bellini
Uriniferous tubule segment locations are constant (recognizable regions)
3 primary topographical regions in kidney
Cortical labyrinth
Cortical ray
Medulla
In each region, 3 different tubular segments easily recognized (marked with
asterisk)
Cortical Labyrinth
Glomerular capsule of Bowman*
Proximal Convoluted Tubule*
Thick, ascending segment of Henle’s loop
Distal Convoluted Tubule*
Arched Collecting Duct
Cortical Ray
Straight portion of Proximal Convoluted Tubule*
Thick Ascending Segment of Henle’s Loop*
Straight Collecting Tubule*
Medulla
Straight portion of Proximal Tubule (thick, descending
segment of Henle’s Loop)
Thin segment of Henle’s Loop*
Thick, ascending segment of Henle’s Loop*
Straight Collecting Tubule; Papillary Duct of Bellini*
Tubule Characteristics
Epithelium is specific to each segment (secretory tubule)
Epithelium of excretory ducts is of one structural type
All rest on a basement membrane
Parietal layer
Visceral layer
Renal Corpuscle and the Filtration
Membrane
Neck – very short segment of tubule!
Parietal layer opens into neck (urinary pole)
Rapid epithelial change: flat capsular cells rise to cuboidal then to
low columnar
Proximal Convoluted Tubule – longest (14 mm.), broadest (60 μ) tubule segment
Most of bulk of pars convoluta (cortex)
Remarkably contorted tubule!
Location: Immediate vicinity of renal corpuscle
Enters medullary (cortical) ray in ray to medulla
Straightens in ray (= straight portion of proximal tubule or thick
descending segment of Henle’s loop)
Cells are low columnar
Cell limits indistinct
Nuclei: large, pale, spheroidal – 3 to 4 show in
transverse section
Free surface: brush border – resorpitive function
Thin Segment of Henle’s Loop
Location: boundary zone of medulla
Sharp transition from thick proximal tubule: reduced to 2 to 10 mm. long &
15 μ wide
Resembles a capillary but is larger & thicker walled
Short or long and recurved
If this part extends past apex of loop: makes sharp hair-pin bend
Interlocking cells – squamous with pale cytoplasm
Brush border is absent
Microvilli present (can see on EM)
Nuclei flat, bulge into lumen
Collecting Duct
Thin Segment
Muscularis
largely confined to prostatic & membranous segments
inner layer (smooth muscle) – longitudinal
outer layer (smooth muscle) – circular
best developed at bladder neck – forms sphincter
cavernous segment lacks smooth muscle layers
longitudinal muscle – in true erectile tissue
Adventitia
No typical adventitia present
Prostatic urethra – surrounded by prostate gland
Membranous urethra – encircled by sphincter of
skeletal muscle
Cavernous urethra surrounded by erectile tissue &
dense outer sheath (neither belong to urethra)
The Histology of the Organs that Collect and
Transport Urine
Figure 26.20a