By
DEPARTMENT OF PHARMACOLOGY
ISRA UNIVERSITY
HYDERABAD, SINDH
1. INTRODUCTION
Group I:
Patients were administered oxygen, intravenoushydrocortisone
and nebulization with ventoline solution
Group II:
Patients were administered intravenous magnesium sulfate besides
oxygen administration, parenteral Hydrocortisone and
nebulization by ventoline solution
4.5. Sampling technique:
Non Probability Sampling
4.6. Sample Selection:
4.6.1. Inclusion criteria:
1. Hospitalized patients with acute asthma between
the ages of 10 to 40 years.
2. Patients having Peak Expiratory Flow Rate is >
50 %.
3. Those who give informed consent
4.6.2. Exclusion criteria:
1. Congestive cardiac failure
2. Coronary artery disease
3. Diabetes mellitus
4. Renal insufficiency
5. Hypertension
6. Pnemonaemias
7. Pregnancy
8. Patients with temperature > 39.8OC
9. Patients who are unable to use expiratory flow meter.
4.7.1. Sample collection (investigations)
Parameters:
Pulse
Blood pressure
Respiratory rate
Peak Expiratory Flow Rate
Oxygen saturation
4.8. Treatment protocol:
After carrying out initial assessment, selected patients
were divided into the following groups:
4.8.1. Group A:
Patients received conventional treatment of 0.5 ml of
Salbutamol (2.5 mg) by neublizer and oxygen therapy,
followed by 100 mg of Hydrocortisone intravenously.
4.8.2. Group B:
Besides conventional treatment as in group A received after 30
minutes, a dose of Intravenous magnesium sulfate 25 mg per Kg
body weight or maximum 2 g diluted in 100 ml of normal
saline in 20
minutes.
Administration of drugs in the both the groups were monitored
by pulse oxymetry. After a period of 60 and 120 minutes vital
signs, pulse oxymetry and Peak Expiratory Flow Rate (PEFR)
were again recorded for the patients in both the groups.
5. Statistical analysis:
(n = 73)
Respiratory rate
(breaths / Conventional Magnesium
P value
minutes) (n = 36) (n = 37)
P = 0.06
P = <0.0001
RESULTS
Graph No. 2
GRAPH NO. 7
(n = 73)
42
Respiration Rate
37
32 Conventional
27 Magnesium
22
17
12
30 60 120
(Time M inutes)
RESULTS
TABLE NO. 8
Table No. 2
COMPARISON OF OXYGEN SATURATION
BASELINE, AFTER 60 & 120 MINUTES OF TREATMENT
(n = 73)
Conventional Magnesium
Oxygen saturation (n = 36) (n = 37) P value
P = 0.004
P = 0.85
P = 0.23
RESULTS
GRAPH NO. 4
99
97
Oxygen Saturation
95
Conventional
93
Magnesium
91
89
87
85
30 60 120
(Time Minutes)
RESULTS
TABLE NO. 9
Table No. 3
(n = 73)
Conventional Magnesium
PEFR (L/minute) P value
(n = 36) (n = 37)
P = 0.008
P = 0.23
RESULTS
GRAPH NO. 11
Graph No. 6
(n = 73)
250
230
Peak Expiratory
210 Conventional
190 Magnesium
170
150
30 60 120
(Time Minutes)
RESULTS
TABLE NO. 10
Table No. 5
COMPARISON OF PULSE (HEART RATE/MINUTE)
BASELINE, AFTER 60 & 120 MINUTES OF TREATMENT
(n = 73)
Conventional Magnesium
Pulse Rate (beats /minutes): (n = 36) (n = 37) P value
Graph No. 7
COMPARISON OF PULSE RATE (HEART RATE/MINUTE)
BASELINE, AFTER 60 & 120 MINUTES OF TREATMENT
(n = 73
P = < 0.0001
P = 0.91
P = 0.04
RESULTS
Graph No. 8GRAPH NO. 13
(n = 73)
Magnesium Group @ 0, 60 & 120 min
190
170
150
Pulse Rate
Conventional
130
Magnesium
110
90
70
30 60 120
(Time Minutes)
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Occupation:
Address:
Brief history:
Weight (Kg):
Height:
Duration of Asthma (in years):
Number of previous hospitalizations:
Time of arrival:
Hospital stay: