Pembimbing : dr. Rantapina, Sp.B Anatomi Colorectal
Moore, K.L., Dalley, A.I. Clinically Oriented Anatomy. 6th edition. Philadelphia : Lippincott Williams & Wilkins. 2009. Definisi Kanker kolorektal adalah keganasan yang berasal dari jaringan usus besar, terdiri dari kolon (bagian terpanjang dari usus besar) dan atau rektum (bagian kecil terakhir dari usus besar sebelum anus).
Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2016;0:1–9. Epidemiology • Ca coloretal merupakan keganasan ketiga terbanyak, dan merupakan penyebab kematian keempat terbanyak. Terdapat sekitar 1,4 juta kasus baru, dan hampir 700.000 kematian karena ca colorectal pada tahun 2012. • Kematian pada kasus ca colorectal ini banyak terjadi di negara dengan pertumbuhan penduduk yang padat.
Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2016;0:1–9. Insidence and Mortality
Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11. Lyon, France: International Agency for Research on Cancer, 2013. Risk factor Faktor yang tidak dapat Faktor yang dapat dimodifikasi : dimodifikasi : Obesitas Usia tua Merokok Laki laki Alkohol Riwayat inflamatory bowel Kurangnya konsumsi serat disease Genetik
Chyke A. Doubeni,et al. Contribution of Behavioral Risk Factors and Obesity to Socioeconomic Differences in Colorectal Cancer Incidence. J Natl Cancer Inst 2012;104:1353–1362 S. Ghazaleh Dashti, et al. Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2017 March ; 26(3): 366–375. Pathology
Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772. Klasifikasi
Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772. Staging
Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772. Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772. Clinical manifestation BAB berdarah Frekuensi BAB meningkat Anemia Lose weight Nyeri perut
Bohorquez M, Sahasrabudhe R, Criollo A, et al. Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia. Amornyotin. S, ed. Medicine. 2016;95(40):4883 Diagnosis Pemeriksaan penunjang 1. Colonoscopy 2. Colon in Loop 3. PA
Świderska M, Choromańska B, Dąbrowska E, et al. The diagnostics of colorectal cancer. Contemporary
Kuipers EJ, Grady WM, Lieberman D, et al. COLORECTAL CANCER. Nature reviews Disease primers. 2015;1:15065 Pencegahan Modifikasi gaya hidup Skrining rutin 1. RT 2. Fecal test 3. Colonoscopy
Kuipers EJ, Grady WM, Lieberman D, et al. COLORECTAL CANCER. Nature reviews Disease primers. 2015;1:15065 Daftar pustaka 1. Moore, K.L., Dalley, A.I. Clinically Oriented Anatomy. 6th edition. Philadelphia : Lippincott Williams & Wilkins. 2009. 2. Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2016;0:1–9. 3. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11. Lyon, France: International Agency for Research on Cancer, 2013. 4. Chyke A. Doubeni,et al. Contribution of Behavioral Risk Factors and Obesity to Socioeconomic Differences in Colorectal Cancer Incidence. J Natl Cancer Inst 2012;104:1353–1362 5. S. Ghazaleh Dashti, et al. Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2017 March ; 26(3): 366–375. 6. Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762- 772. 7. Bohorquez M, Sahasrabudhe R, Criollo A, et al. Clinical manifestations of colorectal cancer patients from a large multicenter study in Colombia. Amornyotin. S, ed. Medicine. 2016;95(40):4883 8. Świderska M, Choromańska B, Dąbrowska E, et al. The diagnostics of colorectal cancer. Contemporary Oncology. 2014;18(1):1-6. 9. Kuipers EJ, Grady WM, Lieberman D, et al. COLORECTAL CANCER. Nature reviews Disease primers. 2015;1:15065 Terimakasih
