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DISKUSI TOPIK

CA COLORECTAL

Oleh : Nunung Agustia Rini


Pembimbing : dr. Rantapina, Sp.B
Anatomi Colorectal

Moore, K.L., Dalley, A.I. Clinically Oriented Anatomy. 6th edition. Philadelphia : Lippincott
Williams & Wilkins. 2009.
Definisi
Kanker kolorektal adalah keganasan yang berasal dari jaringan
usus besar, terdiri dari kolon (bagian terpanjang dari usus
besar) dan atau rektum (bagian kecil terakhir dari usus besar
sebelum anus).

Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2016;0:1–9.
Epidemiology
• Ca coloretal merupakan keganasan ketiga terbanyak, dan merupakan
penyebab kematian keempat terbanyak. Terdapat sekitar 1,4 juta
kasus baru, dan hampir 700.000 kematian karena ca colorectal pada
tahun 2012.
• Kematian pada kasus ca colorectal ini banyak terjadi di negara
dengan pertumbuhan penduduk yang padat.

Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2016;0:1–9.
Insidence and Mortality

Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality
Worldwide: IARC Cancer Base No. 11. Lyon, France: International Agency for Research on Cancer, 2013.
Risk factor
Faktor yang tidak dapat Faktor yang dapat dimodifikasi :
dimodifikasi :
 Obesitas
 Usia tua
 Merokok
 Laki laki
 Alkohol
 Riwayat inflamatory bowel
 Kurangnya konsumsi serat
disease
 Genetik

Chyke A. Doubeni,et al. Contribution of Behavioral Risk Factors and Obesity to Socioeconomic Differences in
Colorectal Cancer Incidence. J Natl Cancer Inst 2012;104:1353–1362
S. Ghazaleh Dashti, et al. Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene
Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2017 March ; 26(3): 366–375.
Pathology

Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to
colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772.
Klasifikasi

Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to
colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772.
Staging

Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to
colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772.
Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential application to
colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-772.
Clinical manifestation
 BAB berdarah
 Frekuensi BAB meningkat
 Anemia
 Lose weight
 Nyeri perut

Bohorquez M, Sahasrabudhe R, Criollo A, et al. Clinical manifestations of colorectal cancer patients from a
large multicenter study in Colombia. Amornyotin. S, ed. Medicine. 2016;95(40):4883
Diagnosis
 Pemeriksaan penunjang
1. Colonoscopy
2. Colon in Loop
3. PA

Świderska M, Choromańska B, Dąbrowska E, et al. The diagnostics of colorectal cancer. Contemporary


Oncology. 2014;18(1):1-6.
Tata laksana
 Pembedahan
 Kemoterapi
 Radiasi

Kuipers EJ, Grady WM, Lieberman D, et al. COLORECTAL CANCER. Nature reviews Disease primers.
2015;1:15065
Pencegahan
 Modifikasi gaya hidup
 Skrining rutin
1. RT
2. Fecal test
3. Colonoscopy

Kuipers EJ, Grady WM, Lieberman D, et al. COLORECTAL CANCER. Nature reviews Disease primers.
2015;1:15065
Daftar pustaka
1. Moore, K.L., Dalley, A.I. Clinically Oriented Anatomy. 6th edition. Philadelphia : Lippincott
Williams & Wilkins. 2009.
2. Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut
2016;0:1–9.
3. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and
Mortality Worldwide: IARC Cancer Base No. 11. Lyon, France: International Agency for
Research on Cancer, 2013.
4. Chyke A. Doubeni,et al. Contribution of Behavioral Risk Factors and Obesity to Socioeconomic
Differences in Colorectal Cancer Incidence. J Natl Cancer Inst 2012;104:1353–1362
5. S. Ghazaleh Dashti, et al. Alcohol Consumption and the Risk of Colorectal Cancer for
Mismatch Repair Gene Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2017 March ;
26(3): 366–375.
6. Grady WM, Markowitz SD. The molecular pathogenesis of colorectal cancer and its potential
application to colorectal cancer screening. Digestive diseases and sciences. 2015;60(3):762-
772.
7. Bohorquez M, Sahasrabudhe R, Criollo A, et al. Clinical manifestations of colorectal cancer
patients from a large multicenter study in Colombia. Amornyotin. S, ed. Medicine.
2016;95(40):4883
8. Świderska M, Choromańska B, Dąbrowska E, et al. The diagnostics of colorectal
cancer. Contemporary Oncology. 2014;18(1):1-6.
9. Kuipers EJ, Grady WM, Lieberman D, et al. COLORECTAL CANCER. Nature reviews Disease
primers. 2015;1:15065
Terimakasih

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