PRO-KITA VII

AScA Team
Mentor :
Endah Sri Utami

Leader : Berta Yulianti

Member : Sudarisman
Saeful Bachri
Dodi Arisanto
Mursidik
PRO-KITA
Improvement pada proses
penimbangan & granulasi
ASPILETS CHEWABLE TABLET
PENDAHULUAN
Latar Belakang
 Penimbangan bahan baku & proses
pembuatan binder solution pada produk
Aspilets Chewable tablet terlalu lama
dan kurang efisien

 Continual improvement

Tujuan
 Peningkatan efisiensi melalui penurunan
waktu dan biaya tanpa penurunan
kualitas produk
 ANALISA MASALAH
MATERIAL MANUSIA

Waktu Proses
Penimbangan

Inefisiensi pada tahap

penimbangan & granulasi
Aspilets Chewable Tab
Kesehatan efisiensi

Waktu Tunggu
Waktu Tunggu

Keamanan Listrik

LINGKUNGAN METODE MESIN

 JADWAL PERTEMUAN

 Frekuensi:
Sebulan sekali

 Kehadiran:
Tidak kurang dari 80%

 Waktu:
± 60 menit
 PEMECAHAN MASALAH

What? Improvement pada penimbangan bahan

baku & pembuatan binder solution
Why? Biaya tinggi dan waktu lama
Where? Production area
Who? PRO-KITA Team
When? Dimulai Juni 2012
How? Sosialisasi SOSIALISASI PROJECT.pptx
Kalibrasi stainless steel container
Validasi proses
Evaluasi
 PERLAKUAN PRODUK
TAHAPAN PROSES KONDISI SAAT INI USULAN PROKITA

PENIMBANGAN
- FD&C Yellow No. 5, p.d 89-93% 6 kali /MO No. 3 kali /MO No.
- Corn Starch 6 kali /MO No. 3 kali /MO No.
- Saccharin Sodium 6 kali /MO No. 3 kali /MO No.
GRANULASI – Wet compounding
- Fluid Bed Dryer Glatt WSG-120 Binder sol. dibuat Binder sol. dibuat
6 kali/MO No. 3 kali/MO No.

- Fluid Bed Dryer Glatt WSG-60 Binder sol. dibuat Binder sol. dibuat
6 kali/MO No. 3 kali/MO No.
GRANULASI – Dry mixing
Preblend/Premixing
Monobasic Sodium Phosphate
Talc
FDC Yellow No. 5 Al. Lake 23-29% 9 kali/MO No. 3 kali/MO No.
Orange Flav-O-Lok
 ASSAY GRANULE

3
12-1045

2 AVE
12-0903 MAX
MIN
1

90.0 92.0 94.0 96.0 98.0 100.0 102.0 104.0 106.0

Acetyl Salicylic Acid (90.0 - 110.0 %)

ASSAY GRANULE

3
12-1045

2 AVE
12-0903
MAX
MIN
1
12-0521

0.0 0.1 0.2

Free Salicylic Acid (NMT 3.0%)

 ASSAY TABLET

3
12-1045

2 AVE
12-0903 MAX
MIN
1

12-0521

90.0 95.0 100.0 105.0 110.0

Acetyl Salicylic Acid (90.0 - 110.0 %)

ASSAY TABLET

3
12-1045

2 AVE
12-0903
MAX
MIN
1
12-0521

0.0 0.1 0.2

Free Salicylic Acid (NMT 3.0%)

 DISSOLLITION

3
12-1045

2
AVE

12-0903 MAX

MIN
1

12-0521

84 86 88 90 92 94 96 98 100

Acetyl Salicylic Acid (NLT 80%)

 240 150

PHYSICAL TEST
148

235
146

144
230

142
12-0521 12-0521

12-0903 12-0903

Mils
225 140
mg

12-1045 12-1045

LSL LSL
138
USL USL

220 Linear (12-0521) Linear (12-0521)

136

134
215

132

210 130
1 2 1 2

Individual Weight (218-232 mg) Thickness (135-145 mils)

 100

PHYSICAL TEST
90
0.8

80

0.7

70

0.6

60

12-0521 0.5
50
12-0903 12-0521
N

12-1045 12-0903
0.4
40 LSL 12-1045

USL

30 0.3

20 0.2

10
0.1

0
1 2 0.0
Abration (nmt 0.8 %)
Hardness (35-60 N)
 Weighing of Raw Materials for Binder Solution
FDC Yellow # 5 p.d 89-93% Corn Starch Saccharine Sodium

Before 6 x 5 = 30 minutes 6 x 5 = 30 minutes 6 x 5 = 30 minutes

After 3 x 5 = 15 minutes 3 x 5 = 15 minutes 3 x 5 = 15 minutes

Binder Preparation

Percompounding batch Per MO No.

Before 2 x 25 = 50 minutes 3 x 50 = 150 minutes

After 25 minutes 3 x 25 = 75 minutes

 Preblending/Premixing

Time/preblending Per MO No.

Before 2 minutes 9 x 2 = 18 minutes

After 2 minutes 3 x 2 = 6 minutes

Average Salary Techician Production : Rp 193

per minute
Average electric per minute : Rp 850

Total No. MO June - Oct 2012 : 6

 CALCULATION SAVING ASPILETS CHEWABLE TABLET
JUNE - OCTOBER 2012

ITEM BEFORE PROKITA AFTER PROKITA

Weighing RM for binder sol

- Manhour 540 minutes 270 minutes

- Electric 540 minutes 270 minutes

Binder Sol. Preparation

- Manhour 900 minutes 450 minutes

- Electric 900 minutes 450 minutes

 TOTAL COST SAVING JUNE - OCTOBER 2012

ITEM BEFORE PROKITA AFTER PROKITA COST SAVING

Weighing RM for binder

sol
270
- Manhour 540 minutes 270 minutes minutes Rp 52,110
270
- Electric 540 minutes 270 minutes minutes Rp 229,500

Binder Sol. Preparation

450
- Manhour 900 minutes 450 minutes minutes Rp 86,850
450
- Electric 900 minutes 450 minutes minutes Rp 382,500

Preblending/Premixing

- Manhour 108 minutes 48 minutes 60 minutes Rp 11,580

TOTAL COST SAVING = Rp 762,540

TERIMA KASIH