ANTIBODI MONOKLONAL DAN

POLIKLONAL
Reynardi Sutanto QBD -4
Outline Presentasi

Komplemen
Sitokin
Interleukin
Interferon
 ANTIBODI
MONOKLONAL
1 “Collection of circulating
and membrane-associated
proteins that are important
in defense against
microbes.”

Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia: Elseviers Saunders; 2014`
Klasifikasi Jalur
Kaskade
• Jalur Alternatif
• Nonspesifik
• Aktivasi komplemen di mikroba
• Jalur Klasik
• Spesifik + humoral
• Dipicu ikatan antibodi-antigen
• Jalur Lectin
• Nonspesifik + mirip jalur klasik
• Dipicu ikatan MBL-residu manosa
terminal
Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia:
Elseviers Saunders; 2014`
 Ciri Komplemen
• Enzim Proteolitik
• Membentuk Kaskade  Teramplifikasi berurutan
• Bekerja secara spesifik + nonspesifik

Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia: Elseviers Saunders; 2014`
Fungsi Komplemen
• Opsonisasi
• C3b selubungi mikroba  dikenali reseptor fagosit
• Inflamasi
• C5a dan C3a menarik leukosit (chemoattractants)
• Lisis
• Kompleks protein polimerik merusak membran
mikroba

Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia: Elseviers Saunders; 2014`
 SITOKIN
2 Protein solubel yang
memediasi reaksi imun dan
berfungsi dalam komunikasi
antar sel imun
 Cara Kerja
Sitokin

Kuby J, Goldsby RA, Kindt RA, Osborne BA. Immunology. 4th ed. New York:
W.H. Freeman; 2000.
Klasifikasi Sitokin

Kuby J, Goldsby RA, Kindt RA, Osborne BA. Immunology. 4th ed. New York: W.H. Freeman; 2000.
 Interleukin
Sitokin yang diproduksi
dan bereaksi pada leukosit

Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia: Elseviers Saunders; 2014
 Tipe-tipe
Interleukin
Lebih dari 40 sitokin
merupakan jenis dari
Interleukin mulai dari IL-1
sampai IL-37

Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E et al.

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and
roles in diseases. Journal of Allergy and Clinical Immunology [Internet].
2011 [cited 1 April 2018];127(3):701-721.e70. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/21377040`
 Interferon
Sitokin yang bekerja untuk
mencegah infeksi virus
terhadap sel

Kuby J, Goldsby RA, Kindt RA, Osborne BA. Immunology. 4th ed. New York: W.H. Freeman; 2000.
Khalaf SM. Spotlights on interferon &
interleukin [Lecture notes on internet].
Assiut: South Egypt Cancer Institute;
2013 [cited 2018 Apr 1]. Available from:
http://slideplayer.com/slide/8758566/#
Fungsi Sitokin
• Opsonisasi
• C3b selubungi mikroba  dikenali reseptor fagosit
• Inflamasi
• C5a dan C3a menarik leukosit (chemoattractants)
• Lisis
• Kompleks protein polimerik merusak membran
mikroba

Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia: Elseviers Saunders; 2014`
Ciri Sitokin
• Jumlah kecil
• Bekerja autokrin atau parakrin
• Spesifik (T Helper cell) maupun Nonspesifik (Sel Mast,
Dendritik, Makrofag)

Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia: Elseviers Saunders; 2014`
Referensi
• Abbas A, Lichtman A, Pillai S. Basic immunology. 4th ed. Philadelphia:
Elseviers Saunders; 2014`
• Kuby J, Goldsby RA, Kindt RA, Osborne BA. Immunology. 4th ed. New York:
W.H. Freeman; 2000.
• Khalaf SM. Spotlights on interferon & interleukin [Lecture notes on internet].
Assiut: South Egypt Cancer Institute; 2013 [cited 2018 Apr 1]. Available from:
http://slideplayer.com/slide/8758566/#
• Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E et al.
Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in
diseases. Journal of Allergy and Clinical Immunology [Internet]. 2011 [cited 1
April 2018];127(3):701-721.e70. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/21377040