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Sr.

Author Title Research Outcome


no
Jean GK, John Stress-induced changes in glucocorticoids might
Effects of Chronic stress on plasma
1 RL, Sally MA, mediate some of the physiological changes that
corticosterone, ACTH and prolactin.
Edward HM. occur as the result of chronic stress.
Various stressors applied seem s to induce a
Djordjevic J, Different Activation of ACTH and
different response of the HPA system as judged by
2 Cvijic G, Corticosterone Release in Response to
quantitative changes in ACTH and CORT release.
Davidovic V. Various Stressors in Rats

Jameel MK,
Anuradha RJ,
Effects of Various Physical Stress The rise in serum cortisol level was observed in
Jayashree D,
3 Models on Serum Cortisol Level in both the physical activity models.
Meghana P,
Wistar Rats
Pandit VA,
Melinkeri RR.

Lin YH, Liu Long term exposure to multiple stressors promotes


Effect of chronic unpredictable mild
AH, Xu Y, Tie clinical depression and CUMS is considered a
4 stress on brain-pancreas relative
L, Yu HM, Li realistic means of producing an animal model of
protein in rat brain and pancreas.
XJ. depression.

Gianluigi G,
Glucocorticoid Receptor and FKBP5
Francesca C, The hypothalamus–pituitary–adrenal (HPA) axis is
Expression Is Altered Following
Christoph A, the major system involved in stress response and its
5 Exposure to Chronic Stress:
Giorgio R, dysregulation is an important element in the
Modulation by Antidepressant
Carmine MP, pathogenesis of depression
Treatment
Marco AR.
Sr.
Author Title Research Outcome
no

Progressive and dynamic relationships between


6 Constance H. Stress and Depression
stress and depression over time

In type 2 diabetic subjects, hypothalmic-


Chiodini I, Adda pituitary-adrenal activity is enhanced in
G, Scillitani A, Cortisol secretion in patients with patients with diabetes complications and the
7
Coletti F, Morelli V, Type-2 Diabetes. degree of cortisol secretion is related to the
Di Lembo S, et al. presence and number of diabetes
complications.

Depression in diabetic patients : Depression is common in both type 1 and type


Lustman PJ,
8 The relationship between mood and 2 diabetes and has significant effects on the
Clouse RE.
glycemic control course and outcome of this medical illness.

Karolina P, Utility of the chronic unpredictable CUMS models play a role in understanding
9 Barbara B, mild stress model in research on pathophysiological mechanism of depression
Grazyna B. new antidepressants and efficacy of antidepressant therapy

Mineur YS, Effects of unpredictable chronic Most effects of UCMS can be reversed by
10 Belzung C, Crusio mild stress on anxiety and antidepressant agents, illustrating a strong
WE. depression-like behavior in mice predictive validity
Sr.
Author Title Research Outcome
no

Biala G, Pekala
K,Boguszewska- Administration of metyrapone (50
Behavioral and Biochemical Interaction Between
Czubara A, mg/kg), a glucocorticosteroid
11 Nicotine and Chronic Unpredictable Mild Stress
Michalak A, antagonist, alleviated the depressive
in Mice
Kruk-Slomka effect induced by the CUMS.
M,BudzynskaB.

In depressed DM2 patients, SSRIs are


Effects of antidepressants on glucose metabolism the only class of antidepressants with
12 Michael D.
and diabetes mellitus type 2 in adults confirmed favorable effects on
glycemic control.

Flandreau EI, Main effect of escitalopram on GR


Escitalopram alters gene expression and HPA axis
Bourke CH, expression almost certainly
reactivity in rats following chronic overexpression
13 Ressler KJ, Vale contributed to the decrease in HPA
of corticotropin-releasing factor from the central
WW, Nemeroff axis reactivity seen in escitalopram-
amygdala.
CB, Owens MJ. treated rats.
Sr.
Author Topic Outcome
no

Dhavale HS,
Panikkar V, Depression and Diabetes: Impact of Escitalopram showed lower fasting and post-lunch
14 Jadhav BS, Anti-Depressant Medications on blood sugar values on follow up, which was
Ghulghule M, glycaemic Control clinically and statistically significant.
Agari AD.

Modulations of Mammalian Brain


Vivek KG, Bechan Functions by Antidepressant Drugs: Prospects of using phytochemicals as safe and
15
S. Role of Some Phytochemicals as effective alternative medicines
Prospective Antidepressants

Nothdurfter C, Effects of escitalopram/quetiapine


Schmotz C, combination therapy versus The combination therapy, but not the ESC
Sarubin N, Baghai escitalopram monotherapy showed significantly inhibiting
16
TC, Laenger A, monotherapy on hypothalamic- effects on HPA system activity leading to
Lieb M, Bondy B, pituitary-adrenal-axis activity in stepwise down-regulation
Rupprecht R, et al. relation to antidepressant effectiveness
c Author Topic Outcome

The antidepressant and anxiolytic-like effects Risperidone applied at a low dose


Kaminska K,
17 following Co-treatment with escitalopram and enhances the antidepressant-like activity of
Rogoz Z.
risperidone in rats escitalopram in the forced swim test

Kumar K, Escitalopram group showed a significant


Salman MT, Comparative effect of agomelatine versus reduction in FBG. Escitalopram seems to be
Shukla V, escitalopram on glycemic control and better than Agomelatine for glycemic
18
Ahmad A, symptoms of depression in patients with type control and ameliorating symptoms of
Verma VK, 2 diabetes mellitus and depression depression in patients of T2DM and
Rizvi DA, et al. depression.

Ravid D, Escitalopram or Novel Herbal Mixture


Blood corticosterone levels were reduced
Dafna L, Ziv Treatments during or following
following treatment with the herbal
19 V, Layla B, Exposure to Stress Reduce Anxiety-Like
treatment or escitalopram, when treated
Motty F, Shir Behavior through Corticosterone and
during or following exposure to stress
A, et al. BDNF Modifications
Sr.
Author Title Research Outcome
no
Quercetin administration to rats
Suppressive effect of quercetin on acute stress- significantly suppressed WIR stress-
Kawabata K,
20 induced hypothalamicpituitary- induced increase of plasma
Kawai Y, Terao J.
adrenal axis response in Wistar rats corticosterone and adrenocorticotropic
hormone levels
Quercetin treatment (50mg/kg, i.p)
repaired this change and prevented the
Tayaa H, Bouhali, Quercetin, a Natural Flavonoid, Mitigates
persistence of stress induced disorders
21 Imed E, Tahraoui Restraint Stress Induced Anxiety-Like
behavior. Finally, intake of quercetin
A. Behavior in Male Wistar Rat
seems to be beneficial for persons
suffering from stressful events.
Soo-Mi J, Min-
Quercetin ameliorates hyperglycemia and Quercetin could be effective in
Jung K, Ha-Neul
22 dyslipidemia and improves antioxidant status improving hyperglycemia, dyslipidemia
C, Ji-Hye K, Jung-
in type 2 diabetic db/db mice and antioxidant status in type 2 diabetes.
In K.
Rutin and berberine at higher doses
significantly decreased the immobility
Viswanth RS,
23 Evaluation of antidepressant activity of rutin periods in a dose dependent manner in
Kappera S.
and berberine in different behavioral models. both tail suspension test (TST) and
forced swim test (FST).
Altamash JM,
Anti-stress activity of flavonoids Rutin and Rutin and quercetin caused a significant
Amogh RL,
24 Quercetin isolated from the leaves of Ficus anti-stress effect after oral administration
Shaijesh W, Jyoti
benghalensis 2 at 80 mg and 100 mg/kg respectively.
BS
[1] Jean GK, John RL, Sally MA, Edward HM. Effects of chronic stress on
plasma corticosterone, ACTH and Prolactin. Physiol Behav.
1987;40(6):775-779.
[2] Djordjevic J, Cvijic G, Davidovic V. Different Activation of ACTH and
Corticosterone Release in Response to Various Stressors in Rats, Physiol
Res. 2003;52: 67-72.
[3] Jameel MK, Anuradha RJ, Jayashree D, Meghana P, Pandit VA and
Melinkeri RR. Effect of various physical stress models on serum cortisol
level in Wistar Rats. J Clin Diagn Res. 2014 Mar; 8(3):181–183.
[4] Lin YH, Liu AH, Xu Y, Tie L, Yu HM, Li XJ. Effect of chronic
unpredictable mild stress on brain-pancreas relative protein in rat brain and
pancreas. Behav Brain Res. 2005 Nov 30;165(1):63-71.
[5] Gianluigi G, Francesca C, Christoph A, Giorgio R, Carmine MP, Marco
AR. Glucocorticoid Receptor and FKBP5 Expression Is Altered Following
Exposure to Chronic Stress: Modulation by Antidepressant Treatment.
Neuro psychopharmacology. 2013;38:616–627.
[6] Constance H, Stress and Depression, Annu. Rev. Clin. Psychol.
2005;1:293–319
[7] Chiodini I, Adda G, Scillitani A, Coletti F, Morelli V, Di Lembo S, et al. Cortisol
secretion in patients with type 2 diabetes: relationship with chronic complications.
Diabetes Care. 2007 Jan;30(1):83-8.
[8] Lustman PJ, Clouse RE. Depression in diabetic patients: the relationship between
mood and glycemic control. J Diabetes Complications. 2005 Mar-Apr;19(2):113-22.
[9] Karolina P, Barbara B, Grazyna B. Utility of the chronic unpredictable mild stress
model in research on new antidepressants, Curr. Issues Pharm. Med. Sci.
2014;27(2):97-101.
[10] Mineur YS, Belzung C, Crusio WE. Effects of unpredictable chronic mild stress on
anxiety and depression-like behavior in mice. Behav Brain Res. 2006 Nov
25;175(1):43-50.
[11] Biala G, Pekala K, Boguszewska-Czubara A, Michalak A, Kruk-Slomka M,
Budzynska B. Behavioral and Biochemical Interaction between Nicotine and Chronic
Unpredictable Mild Stress in Mice. Mol Neurobiol. 2017 Mar;54(2):904-921.
[12] Michael D. Effects of antidepressants on glucose metabolism and diabetes mellitus
type 2 in adults. Curr Opin Psychiatry. 2013; 26:60–65.
[13] Flandreau EI, Bourke CH, Ressler KJ, Vale WW, Nemeroff CB, Owens MJ.
Escitalopram alters gene expression and HPA axis reactivity in rats following chronic
overexpression of corticotropin-releasing factor from the central amygdala.
Psychoneuroendocrinology. 2013 Aug;38(8):1349-61.
[14] Dhavale HS, Panikkar V, Jadhav BS, Ghulghule M, Agari AD. Depression and
diabetes: impact of antidepressant medications on glycaemic control. J Assoc
Physicians India. 2013 Dec;61(12):896-9.
[15] Vivek KG, Bechan S. Modulations of Mammalian Brain Functions by Antidepressant
Drugs: Role of Some Phytochemicals as Prospective Antidepressants.Evidence Based
Medicine and Practice.2016 Feb;2(1):1-12.
[16] Nothdurfter C, Schmotz C, Sarubin N, Baghai TC, Laenger A, Lieb M, Bondy B,
Rupprecht R, et al. Effects of Escitalopram/Quetiapine combination therapy versus
Escitalopram monotherapy on Hypothalamic-Pituitary-Adrenal-axis activity in relation
to antidepressant effectiveness. J Psychiatr Res. 2014 May;52:15-20.
[17] Kaminska K, Rogoz Z. The antidepressant and anxiolytic-like effects following Co-
treatment with escitalopram and risperidone in rats. Journal of physiology and
pharmacology. 2016;67(3): 471-480.
[18] Kumar K, Salman MT, Shukla V, Ahmad A, Verma VK, Rizvi DA, e al. Comparative
effect of agomelatine versus escitalopram on glycemic control and symptoms of
depression in patients with type 2 diabetes mellitus and depression, IJPSR, 2015; Vol.
6(10): 4304-4309.
[19] Ravid D, Dafna L, Ziv V, Layla B, Motty F, Shir A, et al. Escitalopram or Novel Herbal
Mixture Treatments during or following Exposure to Stress Reduce Anxiety-Like
Behavior through Corticosterone and BDNF Modifications. PLoS ONE.
2014;9(4):e91455.
[20] Kawabata K, Kawai Y, Terao J. Suppressive effect of quercetin on acute
stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. J
Nutr Biochem. 2010 May;21(5):374-80.
[21] Tayaa H, Bouhali, Imed E, Tahraoui A. Quercetin, a Natural Flavonoid,
Mitigates Restraint Stress Induced Anxiety-Like Behavior in Male Wistar Rat.
Global Veterinaria. 2015;15(2):150-155.
[22] Soo-Mi J, Min-Jung K, Ha-Neul C, Ji-Hye K, Jung-In K. Quercetin ameliorates
hyperglycemia and dyslipidemia and improves antioxidant status in type 2
diabetic db/db mice, Nutr Res Pract. 2012 Jun; 6(3): 201–207.
[23] Viswanth RS, Kappera S. Evaluation of antidepressant activity of rutin and
berberine in different behavioral models. Indo American Journal of
Pharmaceutical Research. 2016; 6(08):6455-64.
[24] Altamash JM, Amogh RL, Shaijesh W and Jyoti BS. Anti-Stress Activity of
Flavonoids Rutin and Quercetin isolated from the leaves of Ficus benghalensis.
IJPPR. Human. 2016 Mar;5(4):5-19.