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Ujian PA indra

Membran basalis menebal


Target lession
Vesikel banyak terbentuk pada tipe akut
Sub-acute dermatitis

 Parakeratosis, krusta
 Pemanjangan dan fusi rete ridge
 Spongiosis fokal
Chronic dermatitis

 Hiperkeratosis, hipergranulosis
 Hiperplasia psoriasiform
 Vertical collagen streaking
 Spongiosis kurang
Acute,
Sub-acute, and
Chronic
Pemfigus
vulgaris
• Bula suprabasal
• Akantolisis
• Infiltrat neutrofil &
eosinofil (jarang)
Pemfigus foliaseus

• Vesikel/bula
subkorneal
• Akantolisis
• Infiltrat neutrofil
Hailey-Hailey disease

Banyak diderita oleh remaja


Pemfigoid
bulosa

• Bula subepidermal
• Infiltrat eosinofil
Dermatitis herpetiformis

• Vesikel/bula subepidermal (sel


radang neutrofil)
• Papillary microabscess (ciri
penting) dilihat pada sisi tepi
Epidermolisis bulosa

Vesikel tanpa radang  anak (tanpa


keluhan : nyeri)

Radang sangat minimal


Lepra
• Granuloma tuberkuloid
(diselimuti limfosit)
• Granuloma
oval/memanjang
mengikuti serabut saraf

Granuloma : radang yang ditandai dengan banyaknya koleksi makrofag


Lepra, TT

• Giant cell : Sel Langhans


• Sitoplasma merah
Lepra LL
Epitheloid vs makrofag
Lymphocytes

Dark-staining, round
dense nuclei
Narrow rim of light blue
cytoplasm
Sitoplasma sedikit
Histiocytes
• Vesicular nucleus
• Clear nucleoli
• Gray-blue on H&E

Sel lebih besar, inti


vesikuler, sitoplasma
banyak, batas tidak tegas
dan intinya berjauhan

Larger, paler nucleus &


more abundant
cytoplasm (compared to
lymphocytes)
Neutrophils
Nucleus: multi-lobed
(3-5 lobes)
Neutrofil
Cytoplasm: pale bersegmen
amphophilic granules

Epidermis:
Psoriasis
Impetigo
Dermatophytosis
Dermis:
Dermatitis herpetiformis
Sweet’s syndrome
Eosinophils

Segmented (bilobed) nuclei


Numerous, coarse red
granules w/in cytoplasm

Epidermis:
Arthropod bites
Allergic contact dermatitis
Dermis:
Drug eruptions
Urticaria
Eczematous dermatitis
Plasma Cells
Ovoid, w/ eccentric
round nuclei
Deep purple cytoplasm

Mucous membranes
Syphilis
Leishmaniasis
Granuloma inguinale
Mast cells

Eosinophilic staining
Fried egg appearance
(round central nucleus w/in
amphophilic cytoplasm)

Urticaria pigmentosa &


mastocytosis
Neural tumors
Mucinous areas
Multinucleated giant cells
1. Touton-type
ring of nuclei around a
central core of cytoplasm

Xanthoma
Xanthogranuloma
Multinucleated giant cells

2. Langhans-type
histiocytic giant cells w/
nuclei arranged in a
horseshoe at the
periphery

tuberculous gumma
Multinucleated giant cells

3. Foreign-body type
nuclei haphazardly
scattered throughout
the cytoplasm

idiopathic calcinosis cutis


Epithelioid cells

Large, oval, pale,


vesicular nuclei &
abundant eosinophilic
cytoplasm

Sarcoidosis
Tuberculoid leprosy
Melanophages

Histiocyte containing
phagocytized melanin

Postinflammatory
hyperpigmentation
Fixed drug eruption
Parakeratosis
pyknotic keratinocyte nuclei
w/in the stratum corneum
Orthokeratosis

hyperkeratosis w/o parakeratosis


Hypergranulosis

thickened granular layer


almost always accompanied
by hyperkeratosis
Hypogranulosis

decrease in thickness of the


granular layer
may be seen in any condition w/
parakeratosis
Spongiosis
intercellular edema between
keratinocytes

may lead to
spongiotic
intraepidermal
vesicles
Acantholysis

loss of cohesion between keratinocytes


Epidermal Atrophy

decrease in thickness of epidermis


(s. malpighii)
Vacuolar Degeneration

tiny spaces at the DEJ, often leaving


the junction indistinct

formation of subepidermal blister may


result
Papillomatosis

epidermal and papillary dermal


proliferation upward in
irregular waves
Pseudoepitheliomatous hyperplasia

irregular acanthosis (↑
thickness of st. malpighii) with
downward proliferation of the
epidermis
Follicular Plugging

hyperkeratosis
within hair follicles
Cornoid Lamella

Column shaped parakeratosis


Penyakit kulit : Porokeratosis
Dyskeratotic Keratinocytes
- abnormally or prematurely keratinized individual keratinocytes in
the epidermis that stain intensely pink with H & E

Colloid bodies, Hyaline bodies,


or Civatte bodies (nama lainnya).

Homogeneous, eosinophilic round


structures in lower epidermis or
upper dermis