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Evaluasi Profil Lipid Penggunaan Atorvastatin 20 mg

dan 40 mg terhadap Pasien Dislipidemia di Rumah


Sakit Umum Daerah Madani Palu

Dwi Alfian Junior Hasibuan


G 701 15 038

Dosen pembimbing
1. Alwiyah Mukaddas S.Si., M.Si., Apt.
2. dr. Jimmy Haskel
2

Dislipidemia
Dislipidemia adalah gangguan metabolisme lipid yang
ditandai dengan peningkatan maupun penurunan fraksi lipid
seperti kolesterol total (K-total), trigliserida (TG), Low
Density Lipoprotein (LDL), dan penurunan kadar High Density
Lipoprotein (HDL) (Arsana dkk, 2015)
3
Prevalensi global

Di seluruh dunia, hiperkolesterolemia menyebabkan sekitar 56%


penyakit jantung iskemik dan 18% stroke yang menyebabkan 4,4
juta kematian setiap tahun. Hiperlipidemia dan tingkat
hiperkolesterolemia (kolesterol total ≥201,1mg / dl) meningkat
dari 18% menjadi 31% pada orang dewasa berusia 35-59 tahun
(Zhang dkk, 2008). Target Penelitian
4

Latar Belakang …
1. Berdasarkan hasil penelitian Liu dkk. (2016) di Rumah sakit
China terhadap 591 pasien terdaftar. Sebanyak 297 pasien
menggunakan atorvastatin 40 mg/hari dan sebanyak 294
pasien menggunakan atorvastatin 20 mg/hari yang masing-
masing diterapi selama 3 bulan dengan hasil terapi sebagai
berikut.

Profil Lipid Ator 20 mg/hari Baseline 3 bulan


(mg/dl) (mg/dl)
Trigliserida 150,63 124,05
LDL 119,69 73,36
HDL 46,33 46,33
5

Latar Belakang …

Profil Lipid Ator 40 mg/hari Baseline 3 bulan


(mg/dl) (mg/dl)
Trigliserida 159,49 106,33
LDL 123,74 61,87
HDL 42,53 42,53

Berdasarkan hasil uji statistik P-value tidak terjadi perbedaan


bermakna dari kedua dosis terhadap penurun profil lipid kecuali
pada kadar LDL (p< 0,05)
6

Latar Belakang …
2. Berdasarkan hasil penelitian Agrawal dkk. (2018) di rumah sakit
India yang dilakukan terhadap 240 pasien dislipidemia terdaftar.
Sebanyak 120 pasien menggunakan atorvastatin 40 mg/hari dan
sebanyak 120 pasien menggunakan atorvastatin 80 mg/hari
yang masing-masing diterapi selama 3 bulan dengan hasil terapi
sebagai berikut.

Profil Lipid Ator 40 mg/hari Baseline 3 bulan


(mg/dl) (mg/dl)
Trigliserida 121,31 94,39
LDL 132,72 70,25
HDL 36,95 38,81
7

Latar Belakang …

Profil Lipid Ator 80 mg/hari Baseline 3 bulan


(mg/dl) (mg/dl)
Trigliserida 114,13 83,10
LDL 136,43 67,07
HDL 38,48 39,91

Berdasarkan hasil uji statistik P-value tidak terjadi perbedaan bermakna


antara kedua dosis terhadap penurunan profil lipid kecuali pada kadar
Trigliserida (p < 0,001).
8

Latar Belakang …

Berdasarkan penelitian diatas diketahui terdapat


perbedaan pada profil lipid dari atorvastatin 40
mg/hari di Cina dibandingkan atorvastatin 40
mg/hari di India
9

Rumusan Masalah
» Bagaimana profil lipid darah berupa Kolesterol
Total, HDL, LDL dan Trigliserida dari pasien
dislipidemia pengguna atorvastatin 20 mg dan 40
mg di Rumah Sakit Madani Palu periode
September-November 2018 ?
» Bagaimana perbedaan perubahan profil lipid darah
antara dosis atorvastatin 20 mg/hari dengan
atorvastatin 40 mg/hari di Rumah Sakit Madani
Palu periode September-November 2018 ?
10

Tujuan Penelitian
» Mengetahui profil lipid darah berupa Kolesterol
Total, HDL, LDL dan Trigliserida dari pasien
dislipidemia pengguna atorvastatin 20 mg dan 40
mg di Rumah Sakit Madani Palu periode
September-November 2018
» Mengetahui perbedaan perubahan profil lipid
darah antara dosis atorvastatin 20 mg/hari dengan
atorvastatin 40 mg/hari di Rumah Sakit Madani
Palu periode September-November 2018
11

Metode Penelitian

1. Desain Penlitian
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THIS IS A SLIDE TITLE


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IN TWO OR THREE COLUMNS


Yellow Blue Red
Is the color of gold, Is the colour of the Is the color of blood,
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In the spectrum of sea. It is located has historically been
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A PICTURE IS
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A complex idea can be
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AND TABLES TO
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LET’S REVIEW SOME


CONCEPTS
Yellow Blue Red
Is the color of gold, butter and Is the colour of the clear sky Is the color of blood, and
ripe lemons. In the spectrum and the deep sea. It is located because of this it has
of visible light, yellow is found between violet and green on historically been associated
between green and orange. the optical spectrum. with sacrifice, danger and
courage.

Yellow Blue Red


Is the color of gold, butter and Is the colour of the clear sky Is the color of blood, and
ripe lemons. In the spectrum and the deep sea. It is located because of this it has
of visible light, yellow is found between violet and green on historically been associated
between green and orange. the optical spectrum. with sacrifice, danger and
courage.
25

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CREDITS
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