OLEH:

DR DAYANTI YULIASTUTI, SPPK,MKES

 MATURATION OF BLOOD CELLS
Ciri2 sel matur:
1. Cytoplasmic differentiation ( sitoplasma banyak)
2. Nuclear maturation (intinya matur)
- Density of chromatin (kromatin kasar)
-Disappearance of nucleolus (nukleolus tidak ada)
-Changes in shape. (perubahan bentuk kecil)
3. Reduction in cell size ( ukurannya mengecil)
ABNORMAL MATURATION
1. Abnormal / asynchronic cytoplasmic maturation
-agranular cytoplasm
2. Abnormal nuclear maturation
-abnormally large nucleus
-accelerated or retarded nucleoli reduction
-hypersegmented nucleus in neutrophils
-irregularity in nuclear outline, e.g Rieder cell
3.Abnormal size.
-larger cell e.g in Megaloblastic anemia
-smaller cell e.g. micromyeloblast in AML.
 HEMATOPOIESIS Subdivisions

{
Lymphopoiesis Lym

PMN

stem Granulopoiesis Eos

cell
Bas

Myelopoiesis Monocytopoiesis
Mon

Erythropoiesis RBC

Megakaryopoiesis Pla
Thrombopoiesis
 HEMATOPOIESIS Lineages for Lymphopoiesis

Pluripotent Monocytopoiesis
stem
stem cell Granulopoiesis
cell (Hemocytoblast)
Erythropoiesis
Thrombopoiesis

Lymphoblast Monoblast Myeloblast Pro-erythroblast

Megakaryoblast
Basophilic
Pro-Myelocyte erythroblast

Myelocyte Polychromatic
erythroblast
Orthocromatic
Metamylelocyte
erythroblast

Band granulocyte Reticulocyte Megakaryocyte

Lymphocyte RBC Platelets

Monocyte Granulocyte
 LYMPHOPOIESIS