C = Dose
Vd
t1/2 = 0.693
ke
Cl = Vd x ke
Cp = R = R
Vd x ke Cl
C = plasma concentration of drug
T = dosage interval
B = oral bioavailability
Case 1
If you are taking an anticoagulant drug, your doctor will check your
PT/INR regularly to make sure that your prescription is working
properly and that your PT/INR is appropriately prolonged.
(4) What caused the elevation in the patient’s INR and why?
(5) Why was this patient at increased risk of this adverse event?
Case 2, Question cont’d
(6) How would you adjust the dosages of the drugs and would any
additional laboratory investigations be needed?