IDENTIFICATION OF

MORTALITY RISK FACTOR

OF SEPSIS IN CHILDREN

Rahmawati, idham jaya ganda, st aisyah lawang, dasril daud, martira maddeppungeng

Departement of child health, faculty of medicine, Hasanuddin University, Makassr, Indonesia

Background

Severe sepsis >>

children with
Sepsis → life Cause of morbidity comorbidity  decrease
threatening organ and mortality (50- of immunity.
dysfunction 60%) in children Death is strongly
associated with multiple
organ failure.

2
 Microorganism

PCT ↑
Host : Age, gender,
nutritional status Activation of
Endothelial
Coagulation
cell activation
NO
Thrombocytopenia system
Encephalopathy
Fibrin deposit,
Creatinine ↑ Plasma
thrombocyte
Death aggregation leakage
Hypotension
Nephron cell
MODS damage, Tissue
hepatocellular hypoperfusion

APOPTOSIS
IMPORTANT
 Adrie C, 2007 Children
with sepsis are not
Correlation significantly difference in their
• There is no outcome both boys and girls
between significant
gender and
sepsis
difference
outcome (p = 0,475) Ghuman, dkk, 2013 
there was no significant
difference found (9,9% vs
10,9%)

In children population, hormonal fluctuation, e.g progesterone,

estrogen, and testosterone, does not happen yet, and also the
protective effect of progesterone
4
Age
• This study  age is not a
risk factor for sepsis mortality
(p= 0,18) • Stage of immune development
 the younger the age, the less
• Saraswati D, RSCM (2014) mature the immune system,
 age group < 5 years old is therefore the lower the ability of
not significantly different to the immune system to eradicate
age group ≥ 5 years old , with the pathogen from the body
p value = 0,24 • This study  not proven
• Kaur G, 2014 there was
no any significant correlation
of sepsis mortality in children
age group < 4 years old and
age group ≥ 4 years old (p=
0,17).