Defining failed
induction of labor
Pembimbing Klinik:
• The longer the duration of the latent phase of a woman, the greater
the chance to finally undergo caesarean delivery (P <0.001, for time
both as a continuous and categorical independent variable, even
though> 40% of women whose latent phase persisted ≥ 18 hours
still gave birth normally).
First, the majority of women (ie,> 96%) will enter the active phase
within 15 hours of completing cervical maturation (if needed),
oxytocin initiation, and membrane rupture. These patterns still
exist regardless of whether induction is without
medical indication, after KPD, or after ripening of the cervix.
These data indicate that caesarean delivery should not be carried out
during the latent phase before at least 15 hours after oxytocin and
membranes rupture has occurred. The decision to continue labor
outside this point must be individual, and can consider factors such
as other evidence of the progress of labor.
JOURNAL STUDY
Review Journal Completeness
• Journal title: available
• Author and Institution: available
• Abstract: available
• ntroduction: available
• Method: available
• Result: available
• Discussion: available
• Conclusions and suggestions: : available
• References: : available
• Attachment: none
PICO
Population
– The population in this study was taken from 2008 to 2011,
researchers at Eunice Kennedy Shriver's National Institute of Child
Health and Human Development, the Maternal-Fetal Medical
Network Unit conducted observational research (i.e., the APEX
study).
Population
– In this study, the characteristics of patients included nulliparous,
intrapartum, head presentation at ≥37 weeks with fetuses living at
admission and maternity on a randomly selected day, representing
a third of deliveries over a 3-year period in 25 participating
hospitals.
Indicator
Comparison
– A total of 10,677 women met the inclusion criteria and were available for
analysis, 1725 (16.2%) of whom experienced induction because the KPD
and 5582 (52.3%) experienced ripening of the cervix.
Outcome
– For women who did not come with KPD, the median duration between oxytocin
initiation and membrane rupture was 215 minutes (interquartile range [IQR] 75-
418 minutes) for women undergoing cervical ripening and 180 minutes (IQR 65-
332 minutes) for women who did not undergoing cervical ripening..
Outcome
– The median duration of oxytocin use and membrane rupture (defined in this
analysis as the beginning of the latent phase) for active labor (or cesarean
delivery if active labor was not achieved) was 262 minutes (IQR 141-435
minutes). By 6 hours nearly two-thirds of women have developed from the start
of the latent phase to the active phase, and in most (96.4%) women, the active
phase has been reached in 15 hours.
Outcome
– 169 ruptures were detected intrapartum during emergency SC, and
75 were detected postpartum at laparotomy after vaginal delivery.
– Mothers with rupture detected after labor have a higher percentage of
maternal symptoms or signs than those detected by intrapartum.
Middle time (median) from suspected rupture to labor is 20 minutes
(Q1: 15 minutes, Q3: 30 minutes).
Outcome
– The longer the duration of the latent phase of a woman, the greater the chance
to finally give birth to a cesarean.
– However,> 40% of women whose latent phase survives ≥ 18 hours of vaginal
deliv
Outcome
– Indications for cesarean delivery are grouped according to the phase and stage of
labor. As illustrated, the majority of cesareans at each interval time and especially
at the beginning of the interval time which is <15 hours - are not carried out in the
latent phase.
– Some maternal morbidity (eg chorioamnionitis, postpartum haemorrhage and
bleeding transfusion) also increases in frequency as the latent phase increases.
VIA
Validity
– Research question
Is the data collected in accordance with the purpose of the research?
– Yes. Data taken is in accordance with the research objectives. This study was based on data from an
obstetric cohort of women who gave birth in 25 US hospitals from 2008 to 2011. nulliparous women
who had a single pregnancy in head presentation were eligible for this analysis if they underwent
labor induction.
– Are the inclusion and exclusion criteria in this research clearly defined?
– yes. The inclusion criteria in this study were nulliparous pregnant women; have
a single pregnancy, head presentation at ≥ 37 weeks; and underwent labor
induction taken from 2008 to 2011 from 25 participating hospitals.
– While the exclusionary criteria are the time taken to calculate the latent phase
length (for example, the time at which membrane rupture, the time at oxytocin
initiation, the time at least 5 cm is reached) is not available in the graph and,
thus, the latent phase cannot be determined.
– Are the research subjects explained in detail?
Yes. Subjects in this study were nulliparous, intrapartum women, head
presentations at ≥37 weeks with fetuses living at admission and maternity on a
randomly selected day, representing a third of deliveries over a 3 year period in
25 participating hospitals. The research subjects will be included in the group
according to the inclusion criteria.
Randomization
– Was the randomization list concealed from patients, clinicians, and researchers?
Yes. In this study both patients, researchers and health workers did not know the prescribed
treatment group.
– Is your environment so different from the one in study that the methods could not be use there?
– The environment in this study is different from the environment in Indonesia. However, the same
method can still be used in research conducted in Indonesia.
Conclusion
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