TEMA 13.

2
RESPUESTA ANTIVIRAL
MEDIADA POR LINFOCITOS T
•1. ACTIVACION Y DIFERENCIACION
DE LOS LINFOCITOS T CD8
CITOTOXICOS ANTIVIRALES
 Dos tipos de antígenos generados en dos
compartimientos : endógenos o citosolicos (MHC
de clase I) y exógenos o vesiculares (MHC de
clase II)
 2.- MECANISMO DE LISIS
MEDIADO POR LOS
LINFOCITOS T CITOTOXICOS
•Mechanism of lytic granule release. Recognition of the target MHC class I molecules bound to peptide antigen occurs via the TCR. Once the TCR is engaged, the most
proximal signalling molecule to be recruited is Lck (shown in green). The centrosome (g-tubulin, yellow), which is normally perinuclear, polarises towards the synapse and
docks at the plasma membrane. The granules (LAMP-1, red) migrate towards the centrosome, where they dock and fuse with at the plasma membrane, releasing their
contents into the synaptic cleft, causing target cell destruction.
•Bid, an acronym for BH3-interacting domain death agonist, is a member of the Bcl-2
family of proteins that regulate the permeabilization of the outer mitochondrial
• membrane (OMM), a critical event during apoptosis.

•BAD (Bcl-2-antagonist of cell death).

• BAX:
•BCL-2 Associated X
Apaf-1 (Apoptosis protease-activating factor-1