APLIKASI PENELITIAN KEDOKTERAN UNTUK

PEMBELAJARAN

dr. Mitayani, M.Si. Med.

SASARAN PEMBELAJARAN

Mahasiswa diharapkan untuk:

1. Mengetahui cara penelusuran penelitian kedokteran.
2. Memahami cara menggunakan penelitian kedokteran
sebagai bahan pembelajaran.
PENELUSURAN PENELITIAN KEDOKTERAN

• Cari di website yang sahih.

• Pastikan jurnal tersebut terindeks dalam daftar indeks
internasional yang terpercaya.
JENIS PENELITIAN KEDOKTERAN

• Uji klinis
• Uji diagnostik
• Uji prognostik
• Laporan kasus
• Survey epidemiologi
• Metaanalisis
APLIKASI HASIL PENELITIAN UJI KLINIS
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Comparison of the Effects of Two Auditory Methods by Mother
and Fetus on the Results of Non-Stress Test (Baseline Fetal Heart
Rate and Number of Accelerations) in Pregnant Women: A
Randomized Controlled Trial
Objective: To compare the effects of two auditory methods by mother and fetus
on the results of NST in 2011-2012.
Materials and methods: In this single-blind clinical trial, 213 pregnant women
with gestational age of 37-41 weeks who had no pregnancy complications were
randomly divided into 3 groups (auditory intervention for mother, auditory
intervention for fetus, and control) each containing 71 subjects. In the
intervention groups, music was played through the second 10 minutes of NST.
The three groups were compared regarding baseline fetal heart rate and
number of accelerations in the first and second 10 minutes of NST. The data
were analyzed using one-way ANOVA, Kruskal-Wallis, and paired T-test.
Lanjutan
Results: The results showed no significant difference among the three groups
regarding baseline fetal heart rate in the first (p = 0.945) and second (p = 0.763)
10 minutes. However, a significant difference was found among the three
groups concerning the number of accelerations in the second 10 minutes. Also,
a significant difference was observed in the number of accelerations in the
auditory intervention for mother (p = 0.013) and auditory intervention for fetus
groups (p < 0.001). The difference between the number of accelerations in the
first and second 10 minutes was also statistically significant (p = 0.002).
Conclusion: Music intervention was effective in the number of accelerations
which is the indicator of fetal health. Yet, further studies are required to be
conducted on the issue.
Neuroplasticity Changes of Rat Brain by Musical Stimuli
during Fetal Period
(Siamak Sheikhi, Ph.D., Ehsan Saboory, Ph.D.)
Objective: Fetal development of the central nervous system is an important and sensitive stage
which is affected by many external and internal stimuli. This study aimed to investigate effect of
musical stimuli on fetal rat brain.

Materials and Methods: In this experimental study, twelve female Wistar rats were selected and
evenly assigned to control and musical groups. The females were mated with a male rat of the same
genotype. Musical group was exposed to classic music with 60 dB power for 90 minutes twice per
day from 2nd to 20th day of gestation. The control rats were handled similar to the musical group,
but were not exposed to music. Before parturition, all the dams were anesthetized, and their blood
samples were obtained and used for corticosterone (COS) measurement. They were transcardially
perfused by electron microscope (EM) fixative agent. The fetal brains were extracted intact and used
for slice preparation. Horizontal slices were made for electron microscope preparation, and images
were taken and analyzed in terms of cell density and morphological changes.
Lanjutan

Results: EM observation indicated significant morphological

difference in cellular and intercellular spaces between the
two groups. Music-treated fetuses had significantly higher
cell density in parietal cortex and music-treated dams had
lower COS level.
Conclusion: It was concluded that prenatal music would
have a great impact on neuroplasticity of fetal rat brain, at
least indirectly. Although the rat fetuses cannot hear until
birth, music-induced reduction in COS blood level of dams
might be the reason for neuroplasticity of fetal brain.
APLIKASI HASIL PENELITIAN UJI DIAGNOSTIK
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DAFTAR PUSTAKA

• Sheikhi S, Saboory E. Neuroplasticity changes of rat brain

by musical stimuli during fetal period. Cell J. 2015; 16(4):
448-455.
• Khoshkholgh R, Keshavarz T, Moshfeghy Z, Akbarzadeh
M, Asadi N, Zare N. Comparison of the Effects of Two
Auditory Methods by Mother and Fetus on the Results of
Non-Stress Test (Baseline Fetal Heart Rate and Number
of Accelerations) in Pregnant Women: A Randomized
Controlled Trial. Journal of Family and Reproductive
Health 2016; 10(1): 27-34.
• Cobar-Bustamante AE, Cahueque MA, Caldera G. Visual
Loss After Spine Surgery: Case Report. J Orthop 2016;
13(4): 239-241.
• Yammine K and Violato C. The Effectiveness of physical
models in teaching anatomy: a meta-analysis of
comparative studies. Adv Health Sci Educ Theory Pract.
2016; 21(4):883-895.
• Ihongbe TO and Masho SW. Prevalence, correlates and
patterns of heroin use among young adults in the United
States. Addict Behav 2016;63:74-81.
TERIMA KASIH