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Candidiasis

Kandidiasis/Kandidosis
dr. Messia Paramita / RSUD SLEMAN
Definition
• Fungal infection caused by yeast from genus
Candida  Candida albicans
• Cutaneous candidiasis synd
• Paronichia / onycomycosis
• Chronic mucocutaneous
candidiasis
• GIT
• Respiratory
• GUT
• C. tropicalis, c. krusei, c. auris, etc
Pathophysiology
• Can form true hyphae
and pseudohyphae
• Virulence factor :
– Surface molecule ~
adheren
– Acid protease and
phospholipase ~
penetration
– convert
Sign & Symptom
• Oropharynx
– Oral trush
– Stomatitis
• Glositis
• Cheilosis
• Oesophagus GIT
• Respiratory
• Peritoneal
• Urinary
• Vaginal
Faktor Risiko
• Menyuburkan pertumbuhan jamur
– AB yang menyebabkan gangguan keseimbangan
microorg.
– DM atau kehamilan

• Mempermudah invasi jamur


– Rangsangan setempat terlokalisir oleh cairan yng
menyebabkan pelunakan kulit.
– Penyakit tertentu : malnutrisi, immunodefisiensi
– Prosedur medis
Oropharyngeal
Candidiasis
• History : HIV, dentures,
DM, AB exposure, or Types :
inhalesd steroids. • Membranous –
• Symp : common types
– Sore anf painful mouth • Denture (chronic
– Burning sensation atrophic)
– Dysphagia • Erythematous – palate
– Thick, whitish patch on
• Angular cheilitis
the mucosa
• Mixed
Candidiasis
Oesphageal
• Normal oral mucosa
• Dysphagia
Genitourinary
• Odynophagia • Vulvovagina
• Nausea & Vomit • Balanitis
• Cystitis
• Asymp. Candiduria
• Ascending
pyelonephritis
• Fungal balls
Work Up
• KOH & gram staining
• Cultur
• Imaging
– Cutaneous candidiasis
– Oropharyngeal candidiasis
– Vulvovaginal candidiasis
Anti- fungal therapy
• Gentian Violet
• Polyenes derivate  broad spectrum fungicidal agents,
insertion into fungal cytoplasmic membrane  increase
permeability
• : nistatin, amfotericin B

• Azole : triazole + imidazole  destroyed cell membrane and


inhibit sinthesis of protein and RNA  miconazol,
ketoconazole

• Glucan synthesis inhibitor : caspofungin