ARIPIPRAZOLE

(Abilify)
Tabel, Danielle Valerie A.
Tampus, Marvin
Torano, JeannKyle
Tuico, Rogem
Tumbiga, Kaye Patricia
Valladares, Donna
Chemical, Generic & Brand
Name:
– Chemical Name: Aripiprazole; 129722-12-9;
Abilify; Abilitat; Abilify Discmelt; OPC-14597

– Generic Name: Aripiprazole

– Brand Name: Abilify

Brief Summary of Aripiprazole’s
Pharmacokinetics & Pharmacodynamics
Pharmacokinetics
– Half life: 75 hours
– Elimination is mainly through hepatic
metabolism involving 2P450 enzymes: CYP3A4
& CYP2D6
– Oral Administration
– Peak plasma concentration: within 3 to 5
hours
– Can be administered c/s food
– IM Administration
– Peak plasma concentration: 1 h & 3 h
– More effective than oral administration.
Pharmacodynamics
– Psychotropic agent belonging to the chemical class of
benzisoxazole derivatives, indicated for schizophrenia.
– A selective monoaminergic antagonist with high affinity
for the serotonin Type 2 (5HT2), dopamine Type 2 (D2),
1 & 2 adrenergic & H1 histaminergic receptors.
– Antagonism at receptors other than dopamine & 5HT2
with similar receptor affinities may explain some of the
therapeutic and adverse effects of Abilify.
– Aripiprazole’s antagonism of histamine H1 receptors-
Somnolence.
– Aripiprazole’s antagonism of adrenergic a1 receptors-
Orthostatic Hypotension.
Therapeutic Effects of
Aripiprazole:
– An antipsychotic drug used to restore the balance of neurotransmitters in the
brain.
– Used to treat certain mental/mood disorders (such as bipolar disorder,
schizophrenia, Tourette’s disorder, and irritability associated with autistic
disorder).
– May be used in combination with other medication to treat depression.
– Can decrease hallucinations and improve concentration.
Side Effects/Adverse Effects of
Aripiprazole:
– Dizziness, lightheadedness (can cause falls), drowsiness, nausea, vomiting,
drooling, blurred vision, weight gain, constipation, headache, trouble sleeping.
– Tardive dyskinesia (rare)
– Neuroleptic malignant syndrome (rare but very serious)
– Serious side effects: fainting, mental/mood changes, trouble swallowing,
restlessness, tremors, muscle spasm, mask-like expressions of the face,
seizures, trouble controlling certain urges, interrupted breathing during
sleeping.
Special Concerns for Rehab
Patients/Clients who are taking
Aripiprazole:
– Monitor & report signs of neuroleptic malignant syndrome (hyperthermia,
diaphoresis, generalized muscle rigidity, altered mental status, tachycardia,
changes in blood pressure and incontinence).
– Be alert for new seizures or increased seizure activity especially at onset of drug
treatment.
– Assess motor function and be alert for extrapyramidal symptoms. (Tardive
dysknesia, Pseudoparkinsonism, Akathisia and other dystonias & dyskinesias)
– Be alert for suicidal thoughts and ideology.
– Assess levels of drowsiness or lightheadedness, especially in older adults.