Had limitation
Adherence to doxycycline Positive test post therapy Difficult to determine relpas from
not ensured difficult determine incomplete eradication
treatment failure or
Lead to treatmet failure reinfection
Three study of nogonococcal urethritis
other study showed azithromycin efficacy <90%
in male
In two other study azithromycin
vs rifalazil azithromycin
efficacy 92%
In this study choose youth correctional facilities,
1. because chlamydia infection high in this population
To addres the limitation of 2. residents of youth correctional facilities are usually not reexposed to
previous studies untreated partners,
3. treatment is directly observed
4. Screening constant all partners from minimalize infection from ne partener
Inclusion criteria :
Male and female 12 – 21 y.o who were residing in four long-term, sex- segregated youth correctional facilities in
Los Angeles.
Positive screening nucleic acid amplification test result and,
after obtaining written informed consen
Confirm Randomly
Interview chlamydia assigned,
Participant infection ratio 1:1
noninferiority trials was designed to test the null hypothesis that the
absolute rate of azithromycin treatment failure would
be at least 5 percentage points higher than the
absolute rate of doxycycline treatment failure
DOCUMENTED PREVIOUS
CHLAMYDIA INFECTION were evaluated with McNemar’s test.
RESULT
STUDY PARTICIPANT
Azithromycin Two participant vomit within 1 hour after taking it, and a second
dose was administered successfully.
Adverse event 23% (GIT)
Doxycycline 2% 11 dose
3% 12 doses
12% 13 doses
6% 15 dose
1% 16 doses
Adverse event 27%
(GIT) NO PARTICIPANT
DROPOUT
DISCUSSION
DOXYCYCLINE
No treatment we determined adherence the possibility that the efficacy
failure through the staff recording of doxycycline could be offset
directly observed by limited adherence should
treatment be taken into consideration.
AZITHROMYCIN
3% TREATMENT Still unclear
FAILURE
DISCUSSION