Base
Substance that can yield hydroxyl ions (OH-)
Accept protons or H+
Terms
pK/ pKa
Negative log of the ionization constant of an acid
pH
Negative log of the hydrogen ion concentration
pH= pK + log([base]/[acid])
Represents the hydrogen concentration
Terms
Buffer
Combination of a weak acid and /or a
weak base and its salt
What does it do?
Resists changes in pH
Effectiveness depends on
pK of buffering system
pH of environment in which it is placed
Terms
Acidosis
pH less than 7.35
Alkalosis
pH greater than 7.45
Maintenance of H+ concentration
Binds CO2
Curve B: Normal
curve
Curve A: Increased
affinity for hgb, so
oxygen keep close
Curve C: Decreased
affinity for hgb, so
oxygen released to
tissues
Bohr Effect
It all about
oxygen
affinity!
Blood Buffer Systems
• Phosphate Buffer System
• Has a major role in the elimination of H+
via the kidney
• Assists in the exchange of sodium for
hydrogen
• It participates in the following reaction
• HPO-24 + H+ H2PO – 4
Excreted
Carbonic by lungs
acid
Conjugate
base
Bicarbonate
Excreted in
urine
Bicarbonate/carbonic acid buffer system
Allows us to calculate pH
Henderson-Hasselbalch Equation
General Equation
pH = pK + log A-
HA
Lungs/respiratory
Quickest way to respond, takes minutes
to hours to correct pH by adjusting
carbonic acid
Eliminate volatile respiratory acids such
as CO2
Doesn’t affect fixed acids like lactic acid
Body pH can be adjusted by changing
rate and depth of breathing “blowing off”
Provide O2 to cells and remove CO2
Physiologic Buffer Systems
Kidney/Metabolic
Can eliminate large amounts of acid
Can excrete base as well
Can take several hours to days to correct pH
Most effective regulator of pH
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