Maumus M, Sengenes C, Decaunes P et al (2008) Evidence of in situ proliferation of adult adipose tissue-derived progenitor
cells: influence of fat mass microenvironment and growth
Jean-Philippe Bastard et al. Physiology and Physiopathology of Adipose Tissue. 2013
HISTOLOGY
TEJIDO CONECTIVO
WAT BAT
BAT
Magnus Borga et al. Brown Adipose Tissue in Humans: Detection and Functional Analysis
Using PET (Positron Emission Tomography), MRI (Magnetic Resonance Imaging), and DECT
(Dual Energy Computed Tomography). Methods in Enzymology, Volume 537, 2014
BAT
1996–2014 themedicalbiochemistrypage.org
WAT
• TEJIDO CONECTIVO LAXO
• MULTIPLES ESTIRPES CELULARES, CELULAS INMUNES
• SEPTADO
• ALMACENA LIPIDO
• DISTRIBUCION VARIABLE DE ACUERDO A EDAD, SEXO, PATOLOGIAS.
• SUBCUTANEA, VISCERAL
• Función :
• Reserva Energética
• Protección mecánica
• Aislamiento Térmico
• Función Secretora
WAT METABOLIC FUNCTION
HYPOGLICEMIA
WAT
• CORTISOL
• GH
• GLUCAGON
GLUCOSE • ADRENALINE
INS
GLUT4 ?
SENSITIZER
ADIPOCYTE
• OREXIN A
• ADENOSINE
• Nos
WAT FATTY ACID METABOLISM
WAT
10-20 kg of TRIGLYCERIDES
=
90´000 – 180´000 kcal.
ENERGY
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
LYPOLISIS
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Sheila Collins. A heart–adipose tissue connection in the regulation of energy metabolism. NATURE
REVIEWS, ENDOCRINOLOGY, VOLUME 10, MARCH 2014, 157.
WAT
Gwendolyn A. Obesity, Growth Hormone and Exercise. Sports Med (2013) 43:839–849
WAT AND POLLUTANTS WAT
Persistent organic pollutants (POP) • Pesticides
• Dioxins
• Furans
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
Endocrine Functions of Adipocyte WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
Innervation of White Adipose Tissue
WAT
Sarah Stanley et al. Identification of neuronal subpopulations that project from hypothalamus
to both liver and adipose tissue polysynaptically. PNAS | April 13, 2010 | vol. 107 | no. 15
WAT
Nonesterified fatty
acids (NEFAs)
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
ADIPOKINES
WAT
Haitao Pan et al. Advances in understanding the interrelations between leptin resistance and
obesity. Physiology & Behavior 130 (2014) 157–169.
WAT
Tiziana Ronti, Graziana Lupattelli and Elmo Mannarino. The endocrine function of
adipose tissue: an update. Clinical Endocrinology (2006) 64, 355–365
WAT
LEPTIN
WAT
Haitao Pan et al. Advances in understanding the interrelations between leptin resistance and obesity. Physiology & Behavior
130 (2014) 157–169.
ADIPONECTIN
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
APELIN
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
INFLAMMATION
WAT
Christine McGown. Adipose Tissue as an Endocrine Organ. Clin Liver Dis 18 (2014) 41–58
H. James Harwood Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis.
Neuropharmacology 63 (2012) 57-75.
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
WAT
Helen Luck et al. Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents.
2015, Cell Metabolism 21, 527–542
WAT
Fredrik Karpe and Katherine E. Pinnick. Biology of upper-body and lower-body adipose tissue—link
to whole-body phenotypes. NATURE REVIEWS | ENDOCRINOLOGY VOLUME 11 | FEBRUARY 2015
WAT
Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.