WEEK 1
Fundamentals of the
Nervous System and
Nervous Tissue
11
Part A
Functions:
Sensory input – monitoring stimuli occurring
inside and outside the body
Integration – interpretation of sensory input
Motor output – response to stimuli by
activating effector organs
Sensory input
Integration
Motor output
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Organization of the Nervous System
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Histology of Nerve Tissue
Astrocytes (CNS)
Microglial cells (CNS)
Ependymal cells (CNS)
Oligodendrocytes (CNS)
Satellite cells (PNS)
Schwann cells (PNS)
Figure 11.3a
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Figure 11.3b Neuroglia.
Neuron
Microglial
cell
Fluid-filled cavity
Cilia
Ependymal
cells
Brain or
spinal cord
tissue
Ependymal cells line cerebrospinal fluid–filled cavities.
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Oligodendrocytes, Schwann Cells, and Satellite
Cells
CNS
PNS
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Neurons (Nerve Cells)
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Nerve Cell Body (Perikaryon or Soma)
Contains the nucleus and a nucleolus
Is the major biosynthetic center
Is the focal point for the outgrowth of neuronal
processes
Has no centrioles (hence its amitotic nature)
Has well-developed Nissl bodies (rough ER) – The
ribosomes is what makes these Nissl Bodies
Granular in the Rough ER (Function of these is
protein synthesis)
Contains an axon hillock – cone-shaped area from
which axons arise
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Processes
Dendritic
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Axons: Structure
Myelin sheath
Outer collar
of perinuclear
cytoplasm Axon
(of Schwann
cell)
Structural:
Multipolar — three or more processes
Bipolar — two processes (axon and dendrite) (In
vision and olfactory)
Unipolar — single, short process
Functional:
Sensory (afferent) — transmit impulses toward the
CNS
Motor (efferent) — carry impulses away from the
CNS
Interneurons (association neurons) — shuttle
signals through CNS pathways
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Comparison of Structural Classes of Neurons
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Comparison of Structural Classes of Neurons
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Neurophysiology
Fundamentals of the
Nervous System and
Nervous Tissue
11
Part B
Figure 11.6a
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Operation of a Voltage-Gated Channel
Figure 11.6b
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Gated Channels
Figure 11.8
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Membrane Potentials: Signals
Figure 11.9
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Graded Potentials
Figure 11.10
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Graded Potentials
Figure 11.11
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Action Potentials (APs)
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Action Potential: Depolarization Phase
Na+ permeability increases; membrane potential
reverses
Na+ gates are opened; K+ gates are closed
Threshold – a critical level of depolarization
(-55 to -50 mV)
At threshold,
depolarization
becomes
self-generating
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Action Potential: Repolarization Phase
Sodium inactivation gates close
Membrane permeability to Na+ declines to resting
levels
As sodium gates close, voltage-sensitive K+ gates
open
K+ exits the cell and
internal negativity
of the resting neuron
is restored
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Action Potential: Hyperpolarization
Potassium gates remain open, causing an excessive
efflux of K+
This efflux causes hyperpolarization of the
membrane (undershoot)
The neuron is
insensitive to
stimulus and
depolarization
during this time
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Action Potential:
Role of the Sodium-Potassium Pump
Repolarization
Restores the resting electrical conditions of
the neuron
Does not restore the resting ionic
conditions
Ionic redistribution back to resting
conditions is restored by the sodium-
potassium pump
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Figure 11.11 The action potential (AP) is a brief change in membrane potential in a “patch” of
membrane that is depolarized by local currents. (1 of 3)
+30
3
0 4 Hyperpolarization is
–55 Threshold
–70 1 1
4
0 1 2 3 4
Time (ms)
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Propagation of an Action Potential (Time = 1ms)
Figure 11.13b
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Propagation of an Action Potential (Time = 2ms)
Figure 11.13c
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Threshold and Action Potentials
Figure 11.14
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Coding for Stimulus Intensity
Length of arrows – strength of stimulus
Action potentials – vertical lines
Figure 11.14
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Absolute Refractory Period
Figure 11.15
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Relative Refractory Period
InterActive Physiology®:
PLAY
Nervous System I: Action Potential
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Saltatory Conduction
Figure 11.16
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PowerPoint® Lecture Slides prepared by Vince Austin, University of Kentucky
WEEK 2
Fundamentals of the
Nervous System and
Nervous Tissue
11
Part C
Sy napses.mpg
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Types of Synapses
Figure 11.19
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Termination of Neurotransmitter Effects
Figure 11.20a
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Inhibitory Synapses and IPSPs
Figure 11.20b
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Summation
InterActive Physiology®:
PLAY
Nervous System II: Synaptic Potentials
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Summation
Figure 11.21
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Neurotransmitters
Acetylcholine (ACh)
Biogenic amines
Amino acids
Peptides
Novel messengers: ATP and dissolved gases NO
and CO
Include:
Catecholamines – dopamine, norepinephrine (NE),
and epinephrine
Indolamines – serotonin and histamine
Include:
GABA – Gamma ()-aminobutyric acid
Glycine
Aspartate
Glutamate
Include:
Substance P – mediator of pain signals
Beta endorphin, dynorphin, and enkephalins
ATP
Is found in both the CNS and PNS
Produces excitatory or inhibitory responses
depending on receptor type
Induces Ca2+ wave propagation in astrocytes
Provokes pain sensation
Figure 11.23a
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G Protein-Linked Receptors
Figure 11.23b
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G Protein-Linked Receptors: Effects
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Types of Circuits in Neuronal Pools
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Types of Circuits in Neuronal Pools
Convergent –
opposite of
divergent
circuits, resulting
in either strong
stimulation or
inhibition
Figure 11.25c, d
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Types of Circuits in Neuronal Pools
Figure 11.25e
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Types of Circuits in Neuronal Pools
Figure 11.25f
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Patterns of Neural Processing
Serial Processing
Input travels along one pathway to a specific
destination
Works in an all-or-none manner
Example: spinal reflexes
Parallel Processing
Input travels along several pathways
Pathways are integrated in different CNS systems
One stimulus promotes numerous responses
Guided by:
Scaffold laid down by older neurons
Orienting glial fibers
Release of nerve growth factor by astrocytes
Neurotropins released by other neurons
Repulsion guiding molecules
Attractants released by target cells
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N-CAMs