Group 8
DEFINITION:
Cytotoxic
‘toxic to cells’
GOAL OF CHEMOTHERAPY
1) Cure : eradication
2) Control: stop the growing and spreading
3) Palliation:
when cure and control are not possible
- relieve symptoms caused by cancer
- improve QoL
GOAL OF CHEMOTHERAPY
Must be realistic
The primary focus of chemo :
preventing cancer cells from multiplying,
invading adjacent tissue or developing metastasis.
Objective of chemo :
Destroy all malignant cells without excessive
destruction of normal cells
POTENTIAL PATIENT RESPON
Normal
cell
Nucleus
Few
mitoses
Blood vessel
Abnormal
heterogeneous cells
23
CHEMOTHERAPY AND CANCER CELLS
25
1. Toxic limited dose
2. Likely to Resistance
3. 1 cycle of treatment kills < 99,9 %
cancel cells
Combination
Repeated Cycle of treatment
Combination of Chemotherapy