Hyperactivity Disorder
Melissa Stern, M.S.
mkstern@phhp.ufl.edu
A Day in the life of….
Attention-Deficit/Hyperactivity
Disorder
ADHD is a neurodevelopmental
disorder of childhood that is
characterized by developmentally
inappropriate levels of:
Hyperactivity
Impulsivity
Inattention
ADHD: Prevalence
3-9% of the elementary school
population
more often in males than females, with
the sex ratio being about 3:1 to 9:1
most common disorders of childhood
accounting for a large number of
referrals to pediatricians, family
physicians and child mental health
professionals
ADHD Risk Factors
Maternal cigarette use
Maternal alcohol use
Unusually long or short labor
Forceps delivery
Toxemia
Meconium staining
Birth during the month of September
Minor physical anomalies
History of ADHD
Characteristics of this disorder have been
recognized for at least a century
The disorder has been referred to by a variety of
labels:
Minimal Brain Dysfunction (MBD)
Impairment is key
Occupational Impairment
Similar problems to those seen in the
academic environment
Often unprepared, untimely, easily
distracted
“Under Achievers”
Social Impairment
Still there in adolescence and adulthood!
If you don’t attend when people talk, they
often think you aren’t interested
Sensation Seeking/Substance Use
Adolescents and adults with ADHD are
more likely than those with out to engage
in risky behavior including:
Marijuana use
Alcohol Use
Drunk Driving
http://driving.phhp.ufl.edu/
Shameless Plug
Driving Impairment in ADHD is my area of
research
I am going to need an RA or two to help
with my dissertation starting in the Spring
or next fall
If you are a sophomore or junior and are
interested in getting into research, EMAIL
ME! mkstern@phhp.ufl.edu
But What About Cognitive
Impairment
It’s a NEUROdevelopmental disorder,
right?
So why hasn’t this lady mentioned
cognitive problems?
ADHD & Neuropsychological
Deficits
Results from research involving
neuropsychological testing has often
suggested that children with ADHD have
problems:
inhibiting behavioral responses
with working memory
with planning and organization
with verbal fluency
with perserveration
in motor sequencing
with other frontal lobe functions
Neurological Findings
Siblings of children with ADHD who
do not have ADHD, have milder yet
significant impairments in
executive functions
This suggests a possible genetic
risk for executive function deficits
in families
Other Neurological Findings
Differences in cerebral blood flow
Differences in cerebral metabolism
Differences in the corpus collosum
Neurotransmitter Deficits
Neurotransmitter dysfunction in children
with ADHD has been suggested for many
years
Originated from observations of the
response of children with ADHD to
different type of stimulant drugs
The fact that stimulant drugs have an
impact on ADHD and that they increase
dopamine has contributed to the
neurotransmitter dysfunction
hypothesis
Comorbidity & ADHD
Why is it essential to consider the
possibility of comorbid conditions in
assessing children with ADHD?
Importance of distinguishing between
comorbid conditions and mimicry
What is the frequency of comorbidities in
children with ADHD?
Comorbidities
Learning Disabilities - 19 to 26%
Oppositional Defiant Disorder - 40%
Conduct Disorder - 25% children; 45-50%
adolescents
Anxiety Disorders - 30%
Depressive Disorder - 10 - 30%
Bipolar Disorder – up to 20%
Tics and Tourette’s Disorder – 7% of children
with ADHD have a tic disorder
40 to 50% of those with Tourette’s disorder have
ADHD
Onto Assessment and Diagnosis!
American Academy of Pediatrics
Guidelines
Only governing organization with
guidelines for ADHD assessment
Designed for pediatricians
Move toward guidelines in APA
The Interview
Structured or semi-structured
Gold Standard is “The Barkley”
Parent and Self-Report versions
Mostly used in research
Goal is to assess for the three main
symptom areas and evidence of
impairment which meets DSM criteria
Behavioral Observations
This isn’t technically recommended by
AAP
However, if a child is literally climbing the
walls, it might be good to note that
Always remember that children may be
inclined to be on their “best behavior” in
new situations
Coding systems available for looking at
hyperactive and inattentive behaviors
Parent-Report Rating Scales
Shorter measures which ask parents
about frequency, severity, etc. of various
behaviors
Recommended by AAP but not required
Conners’ Parent Rating scale the “Gold
Standard” form
Assesses various aspects of inattention,
hyperactivity, impulsivity
CPRS
Items are rated on a four-point scale from “Not at
all true” to “Very much true”
87 questions
Each question is part of one or more subscales
The parents’ rating on a given question
corresponds to a number 0-3
You sum the numbers for that scale
You plot subscale sums on the profile chart
Scores in the red area are indicative of greater
problems
Parent-Report “Broadband”
Measure
Broadband measures assess a wide array
of social, emotional, and behavioral
problems
They are not recommended for AAP for
ADHD diagnosis
However, they are USEFUL for identifying
comorbid areas of concern
(aggression/conduct problems,
depression)
Teacher Reports
These are essential in assessing for
ADHD
Need to identify impairment in MULTIPLE
SETTINGS
Most children with ADHD will have
academic impairment
Teachers may have the best knowledge of
“developmentally appropriate” levels
because they work with so many children
Teacher Reports
There is a teacher version of the CPRS,
called the Conners’ Teacher Rating Scale
(CTRS)
Modified for the classroom setting but
scored the same way
There are also teacher equivalents of
broadband measures
Problems with Parent and Teacher
Report
Always the issue of informant bias
(wanting to look like a good parent, like a
teacher who can “handle” kids)
Sometimes difficult to get in contact with
teachers and they often don’t return forms
CPRS and BASC may be biased towards
non-European-American Children
Detour: Multicultural Issues in
ADHD
ADHD is not limited to the U.S.
It is seen cross-culturally
However, there is concern it is over-diagnosed in
Low SES and minority children
Compared to parents of Caucasian children,
parents of African-American and Hispanic
children have reported significantly more often
feeling as though their children are over-
diagnosed and over-medicated
Detour: Multicultural Issues In
ADHD
Parents of African-American children less
likely to associate school problems with
ADHD and are less likely to request
behavioral interventions compared to
parents of Caucasian children
Parents of African-American children more
likely to report not knowing the etiology of
ADHD and where to go to receive
treatment for the disorder compared to
parents of Caucasian children
Detour: Multicultural Issues In
ADHD
In studies looking at cross-cultural validity of
several ADHD assessments, found that parents
of African-American children had significantly
higher scores compared to parents of Caucasian
children. Similar findings for teacher ratings
Unclear as to whether this is due to informant
biases, cultural biases of the measure, or actual
ethnic differences
This continues to be an area needing research
Detour: Multicultural Issues In
ADHD
What we do know:
African-American Children respond equally
well to medication treatment compared to
Caucasian children
Generally no differences in doses of
medication
Multimodal treatment superiority effect for
minority children (we will get back to this in a
moment)
Cognitive Measures
Not recommended for use in diagnosis
Most evaluators use them in combination
with many other measures.
These are lab measures that directly
assess impulsivity, inattention, and
executive function
The CPT
Measures attention and impulsivity
Various ways to administer it, but here we
use the “everything but X paradigm”