Figure 5-1
Kulit Dibagi Atas 3 Lapisan Pokok
yaitu :
1. Epidermis atau kutikel
2. Lapisan Dermis (Korium, Kutis
Vera, Trueskin)
3. Lapisan Subkutis (hipodermis
EPIDERMIS :
Lapisan terluar
Dengan aksesoris (rambut,
kuku, kelenjar sebasea, dan
kelenjar keringat )
Epitel Gepeng dengan jenis
sel utama disebut Keratinosit
• Tidak memiliki Pembuluh
darah
Epidermis terdiri atas 4 lapisan :
1. Lapisan basal atau stratum germinativum /Basale
2. Lapisan malpighi atau spinosum
3. Lapisan granular atau stratum granulosum (lapisan
keratohialin)
4. Lapisan tanduk atau stratum corneum
5. Stratum lusidum (langsung dibawah corneum) ada
pada tangan dan kaki
Pada lapisan ini kita dapat menemukan :
• Melanocytes - found in basal layer, manufacture and
secrete pigment
• Merkel cells - basal layer, attached to sensory nerve
endings
• Keratinocytes – Arise from deepest layer of epidermis
to stratum spinosum
Produce keratin – a tough fibrous protein
Produce antibodies and enzymes
Keratinocytes are dead at skin's surface
• Langerhans cells - stratum spinosum, part of immune
system macrophage-like
• Stratified squamous epithelium
• Several distinct cell layers
Thick skin—five layers on palms and soles
Thin skin—four layers on rest of body
• Stratum corneum
Most superficial layer
Dead, flattened (squamous) cells
Abundant keratin - Keratinized
(cornified) tough, water-resistant protein
Protects skin against abrasion and
penetration
Lapisan palinmg tebal dan kuat
Sel poligonal dan berubah jadi gepeng
Mempunyai protoplasma
Scab
Migratory
Macrophages epithelial
and cells
Dermis Sweat fibroblasts
gland
Granulation
tissue
One week after the injury, the scab has After several weeks, the scab has been
been undermined by epidermal cells shed, and the epidermis is complete. A
migrating over the meshwork produced by shallow depression marks the injury site,
fibroblast activity. Phagocytic activity but fibroblasts in the dermis continue to
around the site has almost ended, and the
fibrin clot is disintegrating. create scar tissue that will gradually
elevate the overlying epidermis.
Scar
tissue
Fibroblasts
Table 5-1
• Major Age-Related Changes
Injury and infection increase
Immune cellsdecrease
Sun protection diminishes
Skin becomes dry, scaly
Hair thins, grays
Sagging, wrinkles occur
Heat loss decreases
Repair slows
• Beneficial effect - activates synthesis of
vitamin D3
• Harmful effects
Sun burn
Wrinkles, premature aging
Malignant melanoma
Basal cell carcinoma
Vellus hairs
Body hairs of women and children
Terminal hairs
Hair of scalp
Axillary and pubic area (at puberty)
Hair thinning and baldness
Due to aging
Male pattern baldness
Classified by severity
First-degree burn – only upper epidermis is damaged
Second-degree burn – upper part of dermis is also
damaged
Blisters appear
Skin heals with little scarring
Third-degree burn
Consume thickness ofskin
Burned area appears white, red, or blackened
Figure 5.11a
Basal cell carcinoma
Least malignant and most common
Squamous cell carcinoma
Arises from keratinocytes of stratum spinosum
Melanoma
A cancer of melanocytes
The most dangerous type of skin cancer
Squamous cell carcinoma