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Formulasi

sediaan
sirup
guaifenesi
n
Guaifenesin Pre
Formulasi
Kekuatan sediaan : 50 mg/5 ml
Kelarutan : larut dalam air, etanol,
klorofom, propilenglikol,
agak sukar larut dalam gliserin
Pka :13,62 (Pubchem,2012)
pH : 5-7
Inkompatibilitas : ketidakcocokan dengan bahan pengoksidasi
kuat (cayman cemical, 2017)
Stabilitas :stabil dalam cahaya dan panas
(pubchem,2012)
Efek Farmakologi : Memperbanyak produksi dahak (yang
encer),dan dengan demikian mengurangi kekentalan, sehingga
mempermudah pengeluarannya dengan batuk.
Formulasi utama
Guaifenesin 2% (Zat Aktif)
Sirup simplex 60%(Pemanis)
Propilenglikol 15% (Pengawet)
Sorbitol 15%(Anti-Caploking)
Brillent Red 0,3 %(Pewarna)
Ess.Strawberry 0,6 %(Pengaroma)
Aquadest ad 150 ml
Perhitungan Bahan :

-Guaifenesin 100mg/5 ml
Untuk 1 botol(100 ml) = 100 mg/5 ml x100 ml
=2000mg
Dilebihkan 2 % =150 + (2/100 x150)= 153 ml
- Propilenglikol = 153/5 x 0,7 ml = 21,42 ml
- Sorbitol = 153/ 5x 0,7 ml = 21,42ml
-Brillent Red =153/5 x 0,015 ml = 0,459ml
- Ess. Strawberry = 153/5 x 0,03 ml = 0,918 ml
- Sirup simplex = 153/5 x 3 ml = 91,8 ml
- Aquadest = 153- (0,7+0,7+0,015+0,918+ 3)ml
- = 153 – 5,468 ml
- = 147,5 ml
Pembuatan Sediaan Sirup

1) Disiapkan Alat dan Bahan yang


digunakan
2) Dikalibrasi botol sampai 150ml,diberi
tanda
3) Dilarutkan semua bahan pada masing-
masing pelarut
4) Dicampurkan larutan propilenglikol ke
dalam sirup simplex dan diaduk hingga
homogen
5) Dimasukkan larutan sirup simplex ke
dalam gelas beaker yang berisi larutan
guaifenesin dan diaduk hingga homogen
6) Ditambahkan sorbitol, brillent red, dan
Ess.Strawberry ke dalam larutan yang
pertama
7) Dimasukkan ke dalam botol, dan
diaddkan sampai pada batas yang telah
ditandai
8) Dimasukkan kemasan dan diberi etiket
Evaluasi Sediaan

Penetapan Viskositas
pH
2011 2015

Volume Terpindahkan
Uji Bobot
organolept Jenis
ik
Evaluasi Sediaan

Penetapan
Kadar
dalam
sediaan 2015

Identifika
si Bahan
Aktif
dalam
sediaan
Kemasan

ATURAN PAKAI :

Diminum 2 x sehari sesudah INDIKASI : R


R
makan
Sebagai obat batuk, dengan
memperlancar dahak untuk
KETERANGAN LEBIH keluar.
LENGKAP LIHAT
BROSUR

No. Reg : DBL 1924623837A1

No. Bets : J 903001

Date : March 2019

Exp. Date : March 2022

PENYIMPANAN :

Dalam tempat yang


sejuk,tidak lembap dan
PT. MELAHASTIDY terhindar dari sinar matahari

IND-GTLO
3
Terima kasih
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