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Organizing Science

Research Papers (10)




http://www.chineseowl.idv.tw


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Setting of research (): ?
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Research problem () :
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Quantitative specification of problem () :


Importance of problem () :
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Research objective ()
Methodology to achieve objective
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Anticipated results ()
Contribution to field ()
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Given its extensive use for many centuries,
Chinese herbal medicine has received increasing emphasis
among clinical researchers in Taiwan, as evidenced by the
analysis of its efficacy by several analytical methods.
However, extracting traditional Chinese medicine
requires a large quantity of medicinal components and
cooking for extended periods, making it less efficient to
produce than Western medicine.
For instance, preparing traditional
Chinese medicine for intake requires at least 2 hours in
arrangement, making it an inefficient procedure.
The inability to adopt scientific methods to
extract the valid compounds of traditional Chinese
medicine makes it unfeasible for modern clinical practice
owing to its inefficiency.
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Based on the above, we should develop an extraction
method for the valid compounds of traditional Chinese medicine
through animal-based clinical trials for eventual use in humans.
To do so, components of traditional Chinese
medicine such as Chinese rhubarb can be collected in a
container and then extracted by supercritical fluids. Following
extraction, the traditional Chinese medicine can then be
analyzed quantitatively and qualitatively by LC-Mass. Next,
exactly what chemical elements are found in traditional Chinese
medicine can then be confirmed through analysis. Additionally,
the major chemical components can be adopted in animal or
cell-based experiments.
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As anticipated, the proposed extraction
method can reduce nearly half the time required by
conventional approaches in extracting the valid compounds
of Chinese medicine, making it an economically viable
alternative.
Moreover, the proposed method can
significantly reduce the time required to prepare Chinese
medicine for consumption, as well as ensure safe and
modern applications for clinical medicine.
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As is well known, silver nanoparticles have an affinity with a
proteins thiol and amino group. Surface plasma resonance (SPR), a
biosensor, can detect proteins because silver nanoparticles have a
coating on SPR, necessitating the ability to use SPR sensitively and
accurately SPR to detect proteins. For instance, a protein containing
amyloid -derived diffusible ligands (ADDLs) causes Alzheimers
disease.
Although localized SPR (LSPR) is more sensitive and
accurate than the conventionally adopted SPR, LSPR has many
nanostructures, explaining why sensitivity and accuracy are of priority
concern. Moreover, the conventionally adopted SPR is more
expensive than LSPR.
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While the sensitivity of SPR is 100pM, the
LSPR must have a higher sensitivity and accuracy,
hopefully below 1pM.
Developing a biosensor without a LSPR
would lead to a more expensive detector. Moreover, the
inability to increase sensitivity and accuracy of the
biosensor makes it impossible to detect the bio molecular
structure in early stages, subsequently creating greater
problems such an increased societal burden in caring for
such patients.
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Based on the above, we should design a
sensitive and accurate biosensor that can identify special
proteins efficiently, as well as detect certain diseases in
their early stages. For instance, identifying the protein
ADDLs early can be used to diagnose Alzheimers disease
in its early stages so that therapeutic treatment can be
administered.
To do so, nanoparticles can be developed
in a glass chamber, followed by design of a LSPR
biosensor. The bio molecular structure can then be
detected using LSPR, enabling us to identify the disease.
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As anticipated, the proposed analytical method
for detecting bio molecular structures can detect solution
consistency below 1pM with a high degree of accuracy.
Moreover, the proposed LSPR biosensor can
provide a highly sensitive and accurate means of detecting
the bio molecular structure. The ability to identify the
disease in its early stages can lead to earlier treatment and
recovery. For instance, Alzheimers disease can be
diagnosed early because LSPR can detect ADDLs with a
high degree of sensitivity, ultimately increasing the survival
rate of patients.
Further details can be found at
http://www.chineseowl.idv.tw

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