Writing Medical Abstracts(6)

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2345678
9:; (1 of 3)
! ( "#$%+ "#&') To determine the radioactivity levels
in the human brain, uptake radiopharmaceuticals can be used in brain
imagery to accurately diagnose the early stages of brain-related
diseases. Hoever, according to clinical studies, the amount and
concentration of brain uptake radiopharmaceuticals have a lo stability,
making it impossible to diagnose brain-related diseases accurately and
efficiently. !ore specifically, the chemical structures of traditional
radiopharmaceuticals ("#$) have too many sulfur chemical
comple%es, resulting in radioactivity in the liver. &imultaneously, the
uptake of radiopharmaceuticals in brain radioactivity becomes
increasingly loer, ultimately making it increasingly difficult to
accurately diagnose brain-related diseases for clinical purposes. ()
Therefore, this ork describes a novel high lipophilicity
radiopharmaceutical method that uses to groups of radiochemistry,
i.e. aminedithiolate ligand ('(&) and monothiolate coligand (&), to
increase the radiopharmaceutical high lipophilicity level in order to
maintain a radiopharmaceutical stability and hyperactivities.
9:; (2 of 3)
*+ )minedithiolate and monothiolate are used to one part of
combined **mTc+s , ligand **mTc+s - ligands. .n the ne
radiopharmaceutical, its radiochemical characteristics are then
analy/ed using a high performance li0uid chromatographic
(H12#), ith its amount subse0uently analy/ed using a thin
layer chromatography (T2#). (e%t, the characteristics of high
lipophilicity are analy/ed using a 1artition coefficient 3sing this
radiopharmaceutical sample, its radioactivity is analy/ed as ell
using an automatic gamma counter. 4adiation tracer
characteristics are also analy/ed using multiple-channel pulse
ave e0uipment. )dditionally, the ne radiopharmaceutical
serum is in5ected into laboratory mice, ith the
radiopharmaceutical uptake number of each mouse organ
analy/ed as ell. 6olloing sacrifice of those mice ith
significant organs e%tracted, the organs are eighed and their
radioactivity levels determined as ell. 6inally, the biodistribution
in laboratory mice is analy/ed.
9:; (3 of 3)
,-./01< )nalysis results indicate that the proposed
high lipophilicity radiopharmaceutical method can ensure stability
in a mouse+s brain ith an uptake number e%ceeding ,78 and
other organ+s uptake numbers loer than -98. (e
radiopharmaceuticals can maintain stability si% hours after
fabrication. :lood clearing ratio can then be loer than traditional
radiopharmaceuticals used in brain imagery. =234567
8 4esults of this study contribute to efforts to increase the
clinical accuracy of diagnosing brain diseases as early as
possible for curative purposes, thus enhancing a physician+s
ability to achieve ideal patient management, improve a patient+s
0uality of life, decrease both the mortality rate associated ith
brain-related diseases and the relapse rate and, ultimately, loer
the radiation dose of patients ith brain-related diseases.
9:> (1 of 2)
! ( "#$%+ "#&') #omputer tomography (#T) plays a
prominent role in diagnosing medical ailments oing to its ability to
achieve precise treatment ithout unnecessarily high radiation levels
that ould harm patients. 4estated, hile effective in therapeutic
treatment, #T can not be used during a routine e%amination. "fforts to
integrate #T into routine e%aminations is thus of priority concern.
)lthough medical images are normally taken through conventional %-
ray procedures, such procedures are limited in that hile confined to
capturing three-dimensional ob5ects, many organs overlap each other,
making it impossible to distinguish beteen them. #onversely, #T can
not only detect diseases in their early stages, but also more effectively
treat diseases. (evertheless, #T is not adopted in routine e%aminations
oing to its higher radiation dose than in normal e%aminations.
#onventional medical imagery procedures emit a lo radiation dose
oing to the limited e%posure time. $espite the advantages of #T
images over those of conventional %-ray images, the inability to reduce
its radiation dose to a safe level makes it impossible to detect and
subse0uently treat cancer in its early stages.
9:> (2 of 2)
() Therefore, this study e%amines the feasibility of accelerating the scanning
time during a #T e%amination, thus reducing radiation dose levels. ;hereas the
human body is not proportional ith respect to thickness, the absorbed
radiation dosage is all the same. *+ The ability to ensure that the human
body absorbs a loer radiation dose ith respect to thickness, #T is verified as
an effective physical e%amination procedure for prevention purposes (('T"<
)dd = more sentences to more describe the methodology more completely). ,
-./01< )nalysis results indicate that the accelerated #T scan speed
can scan front and rear positions of the body at varying thicknesses and
radiation dosages, subse0uently reducing a substantial amount of nonessential
dosage and making #T highly promising as a preventive medicine procedure.
&uch a procedure significantly contributes to treatment of lung cancer patients
since !4. does not have a spoke beam. $espite the fact that the loer number
of hydrogen atoms in the lungs does not provide ade0uate information for the
image signal of !4., #T can produce an accurate image of the lungs, making it
relatively easy to detect lung cancer in its early stages. =2345678
4esults of this study demonstrate the ability of #T to reduce the radiation dose
level, making it highly promising as a preventive measure during physical
e%aminations to detect lung cancer in its early stages.
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