MDS (Kuliah TLM 2, Jumat, 12-06-2020
MDS (Kuliah TLM 2, Jumat, 12-06-2020
MYELODYSPLATIC SYNDROMES
MDS
Environmental Exposure
Benzene
Petro chemicals Treatment Related
- alkylating agents
-Busulfan
- cyclophospamide
- mephalan
- Mutasi klonal pada sel –sel hematopoesis
Bone marrow failure hematopoiesis tidak efektif
Abnormal citogenetik (aneuploid lebih sering dibanding
translokasi)
- Mutasi onkogen N-ras oncogene, p53, IRF-1,
antiapoptotic Bcl-2
DARAH TEPI
Internuclear bridging
PEMERIKSAAN TAMBAHAN
Aplastik anemia
Macrocytosis: Megaloblastic Anemia (Vit B12/Folate )
Drug induced cytopenia: Toxic chemical exposure,
kemoterapi/radiasi
Chronic liver disease
Idiopatic citopenia of Undertemined Significance (ICUS)
PENATALAKSANAAN