Lecture Outline
Sensing for health: Vital signs sensors Disease sensors Environmental sensing (mention only) Networking: Requirements for health sensing Wired (serial/USB) and wireless (Bluetooth) systems for sensing, cell phones etc.
Disease Monitoring
Asthma Diabetes
Heart problems
EKG monitoring
Air Quality
Particulate matter Sulfur oxides CO CO2, Nitrogen oxides, hydrocarbons
Water Quality
Bacteria: Typhoid, Cholera, E-coli Protozoa: Cryptosporidium and Giardia Viruses: Hepatitis, many types of diarrhoea Helminths: Parasitic worms, Ascariasis, Hookworm Arsenic: responsible for > 200,000 deaths/year
Pulse oximetry
Pulse oximetry. A light source/sensor on a finger senses light transmission at 650nm and 805nm. These wavelengths are absorbed selectively by oxygenated and non-oxygenated blood. An oximeter signal varies at pulse rate.
Electronic Stethoscopes
A sound transducer connected to a stethoscope head is a very convenient form of the traditional stethoscope. The electronic version can provide amplification, recording, and minimizes artifacts due to cord contact with clothing etc.
Wireless (Bluetooth) Stethoscope Head Intel Physician s Tablet
Exercise pedometers
Accelerometer-based sensors detect leg motion. Sensor typically mounted in the shoe or at the waist. Suunto s T6, Footpod and X9i
Omron
BodyMedia BodyBugg
Vernier Spirometer
Diabetes
The most direct method is blood glucose measurement. A small blood sample is taken by piercing a finger or arm, and analyzed in a handheld meter.
LifeScan OneTouch blood glucose meters. All of these support PC uploads via a serial (RS232) cable.
Diabetes
The Glucowatch uses a method called reverse iontophoresis a small voltage is applied to the skin which draws out intercellular fluid (with glucose in it). The fluid reacts with a gel in a disposable pad, and causes another electrical signal that measures glucose. Received FDA approval in 2002 Extremely valuable for high-risk patients high But readings affected by many factors, perspiration etc., not for everyone Requires (expensive) replaceable pads Company (Cygnus) sold this year Glucowatch G2 device future uncertain
Diabetes
permanent monitors
The best long-term approach seems to be implanted sensors that are accessed wirelessly from outside the body. Many companies (and labs) are working on this. Craig Grimes (Penn. State) developed a magneto-elastic sensor with a polymer coating that responds to Ph (acidity). An additional layer (glucose oxidase) produces acid in the presence of glucose. This sensor, and the electronics to access it, would be extremely inexpensive.
Aside
Grimes group has also demonstrated that these sensors can be tailored to specific pathogens e.g. disease agents in humans, or in contaminated water. The extremely low cost of the sensors and reader electronics opens up many opportunities for environmental health testing in developing regions. Work is needed on two fronts: Sensor chemistry tailoring materials that respond to specific agents Reader electronics reading the sensors requires electronics with high integration for low cost (e.g. systems-on-a-chip) , or modifications to existing SOC hardware (e.g. rfid tag reader chips).
PasPort amp.
Systems
iMetrikus MediCompass
Networking
Once upon a time, There were just cables
Serial connections
Serial Cables connect two devices symmetrically like this:
Tx = transmitted data Rx = received data Serial ports traditionally support speeds up to 19.2k bit/sec (RS232) but are often used at higher speeds (up to several Mb/s) over short distances. Traditional serial ports are fast disappearing on computers, but as we saw still exist on many medical devices.
Bluetooth
Bluetooth is a wireless cable replacement standard. After a slow start, Bluetooth technology is taking off. Sales for 2005 should exceed 200 million units, and is roughly doubling each year. Bluetooth comes in two flavors: Class 2: for personal devices or in-vehicle use, around 1020m (try 10-20 feet in practice) Class 1: For longer range up to 100m, e.g. in a household or office.
Bluetooth Profiles
One of the most useful innovations in the Bluetooth standard is the use of device profiles. A profile is an abstract device spec. that has to be supported at both ends of a connection. If you like, it s the kind of cable(s) that that Bluetooth connection supports. Each connection can support several profiles at once. Profiles eliminate the need for custom drivers on the host, and allows a Bluetooth device to connect to any host (PC, PDA, cell phone) that supports the profile(s) it uses.
Bluetooth Profiles
Bluetooth Stack
The message here is that Bluetooth is hairy like TCP/IP. Older Bluetooth chips only provided HCI functionality. Now they go up to the application layers: SPP, DUN, Headset.
Bluetooth Modules
Free2Move
Bluetooth modules add the components needed to make a working radio: crystal, antenna, flash memory. The current generation of modules measure about 1 x0.5 w/ antenna. Free2Move (Sweden) has some particularly interesting modules based on CSR BlueCore2-flash chips with audio. This radio offers a functioning SPP for serial data, a 15-bit audio channel, and another 8-bit A/D channel.
The newest modules make it pretty easy to go wireless. Most modules can be used as serial cable replacements. The next simplest step is to add a microprocessor to act as controller (PIC etc.), using the module s serial profile. But since new BT chips have a powerful, energy-efficient processor on-board already, this is rather wasteful. You can develop for the native processor, but you will need to buy some expensive development tools. CSR and some module vendors provide virtual machines so your code can t void the module s qualification.
Bluetooth-toBluetooth-to-phone
To call out from a sensor using a Bluetooth cell phone, it may only be necessary to use the phone s DUN (Dialup Networking) profile. The sensor becomes the master of the connection. No code needed on the phone! Otherwise there are several programming platforms available for phones: Java, BREW, Symbian. BREW is the programming environment for CDMA phones (Qualcomm, Sprint, Verizon, ). Fast and flexible, but you need another expensive development environment (for ARM processors).
Project work
Please write down a project idea to be handed in next time (Wednesday). Project work starts next week.
Next Time
Jeff Newman, director of Sutter Health Inst. for Research and Education is the guest speaker. Reading online about telehealth in Finland. What assumptions does this paper make about the application of telehealth? What technical innovations would improve the situation?