Definition
an abnormal progressive condition of the lens of the eye, characterized by loss of transparency. A yellow, brown, or white opacity can be observed within the lens, behind the pupil.
Etiology
Physical Chemical Predisposition of other disease Genetic and development disorder Viral infection in fetal growth Aging
Distortion of lines
Monocular diplopia Altered colours (white objects appear yellowish).
Classification
Classified by etiology Classified by opacities Classified by location of opacity within lens structure Classified by maturity
Classification by etiology
A. Age-related cataract
It is acquired lens opacity occurring old age in the absence of a local or systemic disease. The general features : Always bilateral (one eye precedes the other). Progressive to maturity and hypermaturity. Hard nucleus. No local or systemic disease can be found. Clasification : Cortical Senile Cataract Senile Nuclear Cataract Subcapsular Senile Cataract
B. Congenital cataract
Hereditary Congenital Cataracts Cataract from Transplacental Infection in the First Trimester of Pregnancy Without systemic association : isolated hereditary cataracts Systemic association : metabolic(galactosemia, galaktokinase deficiency), prenatal infection,chromosomal abnormalities, skeletal syndrom Classification :
Lamellar or zonular cataract Opacities are located in one layer of lens fibers, of ten as riders only in the equatorial region Nuclear cataract The lamellar cataract in which initially only the outer layer of the embryonic nucleus is affected. Coronary cataract Fine radial opacities in the equatorial region. Cerulean cataract Fine round or club-shaped blue peripheral lens opacities.
C. Secondary cataract
Drug-induced cataract (e.g. corticosteroids) Diabetic cataract atypical radial snowflake pattern of cortical opacities (snowflake cataract) Galactosemic cataract Deep posterior cortical opacity begins after birth Dialysis cataract swelling of the cortex of the lens Tetany cataract The opacity lies within a broad zone inferior to the anterior lens capsule and consists of a series of gray punctate lesions Dermatogenous cataract (e.g. chronic neurodermatitis, scleroderma, etc) anterior crest-shape d thickening of the protruding center of the capsule
D. Traumatic cataract
Blunt trauma (capsule usually intact) Penetrating trauma (capsular rupture & leakage of lens material)
Classification by opacities
(Lens Opacities Classification System III)
Anterior & Posterior cortical cataract Anterior & Posterior polar cataract Anterior & Posterior subcapsular cataract Nuclear cataract posterior capsular opacification (PCO)
Cortical cataract :
Develops in the outer shell of the lens as spokes and wedges and commonly causes increasing glare sensitivity.
Commonly process due to increased water/ fluid content inside the lens. A history of diabetes or previous heart attack, and a blood factor (fibrinogen) associated with vascular conditions appeared to increase the risk
Tend to be hyperopia
Subcapsular Cataract :
Starts as a small, opaque area just under the capsule shell, usually at the back of the lens
This type of cataract may occur in both eyes but tends to be more
advanced in one eye than the other
Often interferes with reading vision, reduces your vision in bright light
Develops at the back of the lens, often in the visual axis, and so affects vision rapidly and severely The majority of people needing cataract surgery have some posterior subcapsular cataract present at that time
Nuclear cataract :
Develops in the nucleus or centre of the lens, due to hardening process. As it increases, there is an associated yellow or brown discolouration of the lens. smoking, heavy alcohol consumption, sunlight exposure and diabetes increased the risk of nuclear cataract.
Produce myopia
(A, bipolar; B, pyramidal; C, axial; D, subcapsular (cupuliform); E, nuclear; F, coronary; G, snowflake; H, cuneiform)
Classification by maturity
Intumescent The lens becomes swollen by absorbing water. Immature Scattered opacities are separated by clear zones. Mature Cortex and nucleus become totally opaque. Hyper-mature Cataract Mature cataract, which has become smaller and has a wrinkled capsule as a result of leakage of water out of lens. Morgagnian Cataract A Hyper-mature cataract, in which total liquefaction of cortex allows the nucleus to sink inferiorly.
Pushed-forward Shallow
Closed Negative
Negative
Insipien Cataract :
Intumescent Cataract :
Immature Cataract :
Mature Cataract :
Hyper-mature Cataract :
Morgagnian Cataract :
Examinations
Visual acuity : Checking vision of both eyes unaided and aided with glasses and pin-hole vision to know the improvement as well as to get the general idea about the macular function of the eyes. This will help in prognostic evaluation of visual recovery after cataract surgery. Slit-lamp examination : To know the type of cataract along with its opacity, morphology and etiology or any associated ocular pathology. Direct and indirect ophthalmoscopy (Brckners test): : Dense opacity (cataract will prevent retinal evaluation), Under a light source or ophthalmoscope (set to 10 diopters), opacities will appear black in the re d pupil
Prevention
wearing ultraviolet-protecting sunglasses Regular intake of antioxidants (such as vitamin A, C and E) antioxidant N-acetylcarnosine
Treatment
Cataract surgery
extracapsular cataract extraction (ECCE) intracapsular cataract extraction (ICCE) Small Incission Cataract Surgery (SICS) Phacoemulsification
only the cortex and nucleus of the lens are removed ( extracapsular extraction); the posterior capsule and zonule suspension remain intact. This provides a stable base for implantation of the posterior chamber intraocular lens. ECCE is a conventional technique that :
This not only provides support of placement of IOL but also prevents vitreous from bulging forwards and acts as a barrier between anterior and posterior segment
The lens is removed as one single piece i.e., the nucleus and the cortex are removed within the capsule of the lens after breaking
the zonules.
The entire lens is frozen in its capsule with a cryophake and removed from the eye through a large superior corneal incision
There is no support left for posterior chamber IOL, therefore, only anterior chamber IOL (ACL) can be implanted which has risk of adverse corneal complications.
There is no barrier left between anterior and posterior segment, which increases the incidence of other complications e.g., vitreous loss, aphakic glaucoma, cystoid macular edema, endophthalmitis, etc
The difference with ECCE is by the size of the incission (Incission 5-7 mm) Do not need suture
Phacoemulsification
Diabetic Retinopathy
Diabetic Retinopathy
Is a progressive ophthalmic condition that is associated with diabetes and can have devastating consequences
It is a leading cause of blindness in adults of working age and is characterised by capillary leakage, capillary vessel occlusion and subsequent new vessel formation. Retinopathy will develop within 5 years of diagnosis of diabetes in approximately:
25% of people with Type 1 diabetes 40% of people with Type 2 diabetes who are taking insulin 24% of people with Type 2 diabetes who are not taking insulin
Classification
Non-proliferative diabetic retinopathy (NPDR) Proliferative diabetic retinopathy (PDR) Diabetic maculopathy
Capillaries develop leaks and later become occluded. Do not have much effect on vision when they occur in the peripheral retina The retinal changes : Mycroaneurysms Intra-retinal hemorrhages Venous bleeding Excessive hemorrhages Cotton-wool spot (nerve fiber infaction with soft exudates) hard yellow exudates with well defined edges macular edema
Typified by the growth of new vessels on the retina or into the vitreous cavity and thought to result from the ischaemic diabetic retina producing vasoproliferative factors that cause the growth of abnormal new vessels.
Pra-retinal neovascularization Vitreous hemorrhages Tractional retinal detachment Rubeosis iridis (neovascularization of the iris that can occlude the angle of anterior chamber)
Diabetic maculopathy
When diabetic retinopathy causes vessel leakage and ischaemia in the macula area
Focal maculopathy
Ischaemic maculopathy
Symptoms
Asymptomatic for a long time The late stages with macular involvement or vitreous hemorrhage will the patient notice visual impairment or suddenly go blind
Treatments
Control of diabetes Proliferative diabetic retinopathy scatter photocoagulation macular edema focal laser treatment
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