Gen. Histo.
Topics
Cell Epithelium Connective Tissue Blood Leukocyte &Platelets Cartilage and bone Muscular and Nervous
Cell
Nucleus - Large Oval body near the centre of the cell. - The control centre for all activity. - Surrounded by a nuclear membrane. Nucleoplasm - is the protoplasm in the nucleus. - contains genetic material ---> CHROMOSOMES (DNA) Nucleolus - is found in the nucleus. - contains more genetic information (RNA) Cell Membrane - the outer boundary of the cell. - it separates the cell from other cells. - it is porous ---> allows molecules to pass through.
Mitochondria - power house of the cell. - centre of respiration of the cell. - they release energy for cell functions. Ribosomes - tiny spherical bodies that help make proteins. - found in the cyto plasm or attached to the endo plasmic reticulum. Golgi Bodies - tube like structures that have tiny sacs at their ends. - they help package protein. Lysosomes - " suicide sacs " - small structures that contain enzymes which are used in digestion. - if a lysosome were to burst it could destroy the cell.
Epithelium
Epithelial tissues line the cavities and surfaces of structures throughout the body, and also form many glands.
Glandular Epithelium
Columnar epithelium with goblet cells is called glandular epithelium.
Stratified Epithelium.
the epithelia are composed of several layers of cells and are then called compound or stratified epithelium. Pseudostratified Epithelium
Fibers in CTP
Collagenous fibers are the most numerous compared to the other two. Elastic fibers are made up of a substance called elastin, and as their name implies they are highly elastic. Reticular fibers are chemically similar to collagenous fibers and are often continuous with them. Like the elastic and collagenous fibers they divide into many branches but are much thinner than the other two types.
BLOOD
BLOOD...
TISSUE
Composed of: ERYTHROCYTES, LEUKOCYTES and THROMBOCYTES Suspended in fluid : PLASMA (transparent yellow fluid that constitute the extracellular matrix of the blood tissue) Normal vol of blood in the body: 5-6 Liters (7% 0f the body weight) Erythrocytes = 45% Leukocytes and platelets = 1% Plasma = 54%
GENESIS OF RBCS
Proerythroblast Basophil erythroblast (stain with basic dyes) Polychromatophil erythroblast Orthochromatic erythroblast Reticulocyte Erythrocyte
RETICULOCYTE
The RBC is already filled with hemoglobin to a concentration of 34% in this stage The form of RBC wherein the nucleus is condensed to a small size, with its remnant being extruded, while the ER is reabsorbed It still contains a small amount of basophilic material, consisting of remnants of Golgi apparatus, mitochondria, and organelles Its movement from the bone marrow to the capillaries: DIAPEDESIS (squeezing thru the pores of
the capillary membranes)
REGULATORS. .
2. ERYTHROPOIETIN. This circulating hormone
(glycoprotein) is the principal factor that stimulates RBC production Hypoxia has little effect or no effect in stimulating RBC production in the ABSENCE of ERYTHROPOIETIN If the erythropoietin system is FUNCTIONAL, hypoxia can cause the marked increase in erythropoietin production which in return enhances RBC production until hypoxia is relieved
ERYTHROPOIETIN
90% is formed in the KIDNEYS (in the juxtaglomerular portion or by the renal tubular epithelial cells) 10% is secreted or formed by the LIVER When both kidneys are removed or destroyed by disease, the person becomes invariably anemic the remaining 10% produced by the liver can cause or effect only 1/3 to RBC formation as needed by the body
ERYTHROPOIETIN
This hormone also hastens the genesis of RBC Causes the proerythroblasts to pass more rapidly thru the different erythroblastic stages than normally => speeding up production of new cells This rapid production continues as long as the person remains in a low oxygen state or until enough red cells are produced to carry adequate amount of O2 to the tissues despite the low oxygen
Iron Storage
Total quantity of iron in the body: averages 4-5 grams 65% is in the form of hemoglobin, 4% in the form of myoglobin, 1% in the form of various heme compounds that promote intracellular oxidation, 0.1% is combined with the protein transferrin in the blood plasma, 15-30% is stored mainly in the RES and liver parenchyma in the form of FERRITIN
LEUKOCYTES
Spherical in the blood, more or less ameboid in the tissues or on a solid substrate
Kinds of leukocytes
Based on presence of granules
Cartilage
CARTILAGE
Specialized form of connective tissues
Consists of cells :
Chondrocytes Extracellular fibers Gel-like Matrix
Kinds of Cartilage
Hyaline - most common and most characteristic Elastic Fibrocartiloage
Cartilage
Chondrocytes
Lacuna(e) - space for chondrocytes
Bone
Region
Epiphysis @ cancellous bone Diaphysis @ compact bone Metaphysis *Epiphyseal Plate grow in length of long bones
Layer
Periosteum Endosteum