Enzymes are molecules that act as catalysts for all chemical

reactions within the body and are necessary to sustain life Every activity in the body requires enzymes. Thus, depleting the body's enzyme capacity is the root cause of all pains, sprains, injuries, inflammation, indigestion, immune deficiency, and degenerative diseases like cancer and AIDS. Unlike commonly used drugs that temporarily relieve some symptoms, enzymes address the underlying cause and help the body heal faster.

 Historically, the case for pancreatic enzymes in cancer therapy was

first established in the early 1900s by the Scottish Embryologist John Beard. Pancreatin enzymes have two important functions in the body: digestion of foods and routine cancer eradication. Cancer cell membranes have protruding hair-like strands made of carbohydrate. amylase enzymes to dissolve the strands so that trypsin and chymotrypsin can be effective. Nearly all pathogens, including cancer cells, are protected by a protein-based coating, or "fibrin", that makes it difficult for the immune system to identify and destroy them. Consuming protein rich foods at inappropriate times or in excessive amounts can result in a lack of Pancreatin enzymes available to fight cancers that occur.

 Poor diet choices and eating habits can tie up pancreatin

enzymes with digestive tasks so that their cancer elimination capability is reduced.

 Papain is mainly present in papaya. Papain, one of the most

powerful plant proteolytic enzymes, will aid in protein digestion in an acid, alkaline or neutral medium. Papain possesses a very powerful digestive action superior to pancreatin, or pancreatic enzymes. Taken on an empty stomach, it will work more aggressively than even the pancreatic enzymes in attacking and destroying cancer cells. Citrus Pectin has the potential to prevent metastasis, or the spread of cancer.

 Modified citrus pectins small molecules enter the bloodstream

and act as decoys for lectins (cancer cell surface proteins), which are seeking the sugar galactose in cells. Modified citrus pectins small molecules enter the bloodstream and act as decoys for lectins (cancer cell surface proteins), which are seeking the sugar galactose in cells. papaya enzymes digest dead cancer cells.it helps to reduce detox symptoms and inflammation of the tumors. This will also help to reduce tumor size faster.

 Aberrant glycosylation is associated with differential

expressions of enzymes such as glycosyltransferase and glycosidases. The aberrant expressions of the enzymes in turn cause cancer cells to produce glycoproteins with specific cancerassociated aberration in glycanstructures. Cancer biomarker discovery using Aberrant glycosylation in three areas.

 First, changes in glycosylation machinery such

as glycosyltransferases/glycosidases could be used as cancer biomarkers.

Second, most of the clinically useful cancer biomarkers are

glycoprotein. Discovery of specific cancer associated aberration in glycan structures of the existing biomarkers could improve their cancer specificity, such as the discoveryofAFPL3,fucosylated glycoforms of AFP. Third, cancer associated aberrations in glycan structures provide a compelling rationale for discovering new biomarkers using glycomic and glycoproteomic technologies.

 Development of Cytochrome P450-Based Prodrugs Wide distribution of CYP1B1 offers tremendous opportunities

for development of novel prodrugs activated by CYP1B1 only in the tumor cells. prodrugs currently in preclinical evaluation such as : Resveratro ArylOximeProdrugs

Antisense-Based P450Therapy:
A new antisense phosphorodiamidate morpholino oligomer

drug AVI4557 that specifically targets cytochrome P450 CYP3A4(70) has recently completed phase I studies with phaseII studies planned for later this year.

 premetastatic niches which encourage tumour growth and

limit immune response through a range of mechanisms. It releases different substances, one such substance is the enzyme lysyl oxidase (LOX), which appears in elevated levels in hypoxic tumors. Inhibition of LOX has been linked with reduced metastatic growth. LOX is secreted by the primary tumour, and it binds to a protein (fibronectin) in sites of future metastases. The enzyme cross-links collagen, and recruits CD11b+ cells to establish premetastatic sites..

 Some of the oral enzymes are:

Wobenzym 2. Wobe Mugos 3. Papaya Pro

1.

Effects on tumor cells:

Changes in the coating substances and changes in the cell

surfaces (increase in the immunogenicity). Changes in the coating substances and changes in the cell surfaces (increase in the immunogenicity). Exposure of the tumor cell antigens (increase in the immunogenicity).

 Degradation of circulating immune complexes (elimination of

"blocking factors" that cancer cells use to hide themselves).

"blocking factors" that cancer cells use to hide themselves).

Degradation of circulating immune complexes (elimination of

Increase in phagocytosis (complete elimination of the

"blocking factors"). Activation of macrophages and natural killer cells (direct attack against the tumor cells) Secretion of cell messenger substances (TNF,interleukin).

 Makes tumor cells kill selves.

Drug is KG5.
It works in a different way to traditional therapies by altering

the structure of a cancer growth protein ,an enzyme Raf.

Submitted by:

Lochana Patar M.Sc Biotechnology 3rd semester Jain University