Group 5
Jessie Allison
Christina Carreau
Andrea Horta
Rachelle de Jong
Betty Rozendaal
Medical history
• 43 yeo female
• Kidney transplant (3 years ago)
• DVP left calf (18 months ago)
• Protein C Deficiency (incr. risk of blood clots)
• Menopausal
• Drug complications, bruising and bleeding from
antithrombotic drugs
Patient’s Medications
Medications Use
Cyclosporin immunosuppressant anti transplant rejection[i]
Warfarin anticoagulant
Aspirin thrombolytic
Gingko Incr. memory/vasodilator
Mycophenolate mofetil Prevents organ transplant rejection reverses Patients with evidence of bruising, bleeding
ongoing acute infection or infection must report it due to its
association with lymphoma.[ii]
Prednisone In conjunction with other immunosuppressant Adverse Effects: potential for pulmonary
(corticosteroid) drugs i.e. Cyclosporine and MMF, to reduce emboli[iv].
rejection of transplanted organs. [iii]
Glyburide controls hyperglycemia, used as an insulin Should not be given to patients with liver
substitute[v] disease or renal impairment.
Glyburide weakens the effects of Warfarin
(coumarin) derivatives.[vi]
Hydrochlorothiazide diuretic and anti-hypertensive[vii] Can decrease in GFR (similar to
cyclosporine).
Interactions with Prednisone may cause salt
and water retention (hypokalemia) . Could
potentially raise blood pressure.[viii]
Warfarin anticoagulant Risk of hemorrhages. Treatment highly
individualized and monitored.
Potential interactions:
Hydrochlorothiazide (diuretics),
Prednisone (corticosteroid),
immunosuppressives[ix]
Garlic and ginkgo may induce bleeding
events have anti-coagulant, anti-platelet
and/or fibrinolytic activity. Additive effects
to Warfarin’s anti-coagulative effect.[x]
Medications cont’d
Calcium Unknown likely post menopausal bone loss May decrease drug absorption
Question 3
http://www.cafeoflifepikespeak.com/Videos/Licensed%2