Prostaglandin Biosynthesis
Phospholipid
Phospholipase A2 COX-1 constitutive enzyme
Arachidonic Acid
Prostaglandins
Indomethacin blocks here
Prostaglandins
Physiology
Pathology
also indicated for the pain, swelling caused by acute gouty arthritis.
the baby's lungs before birth. Soon after the infant is born and the lungs fill with air, the ductus arteriosus is no longer needed. It usually closes in a couple of days after birth.
PDA leads to abnormal blood flow between the aorta and pulmonary
artery, two major blood vessels that carry blood from the heart.
This structure is kept patent in the fetus by continuous production of
Severe frontal headache CNS Effects: Dizziness, Vertigo, Confusion, Seizures and Psychiatric changes such as depression and psychosis. Mild GI reactions: Nausea and Vomiting, Indigestions More severe GI effects: Ulceration with perforation, hemmorrhage Hematologic reactions: Neutropenia, Thrombocytopenia, aplastic anemia,
Drug Interactions:
1. May decrease the antihypertensive effects of beta-
Potassium-sparing diuretics
Drug Interactions:
4. Probenecid may increase the serum concentration
of indomethacin
5. Concurrent use with other NSAIDs may increase GI
adverse effects
6. May increase the nephrotoxicity of Cyclosporine 7. May increase the serum concentrations of Digoxin,
References:
Basic and Clinical Pharmacology Katzung Pharmacology for Nursing Care Richard A. Lehne (5th Edition) USP 24 Philippine National Drug Formulary Volume II (3rd Edition) http://www.nlm.nih.gov/medlineplus/druginfo/meds/a681027.
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