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V/s GMP

By

Dr Sanand Ratnam Thekkayil


Under the Guidance of Dr Vinay Chandra Shetty H.O.D Dept. of Rasa Sastra

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Word Meaning:
- -
is derived from the root word (Dhatu Roopavali)

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Cont
I (Sasvatha Nighantu)
: ( Medini Nighantu)
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Location of the Pharmacy:


I II ( Rasendra Chudamani 3/1,2) ........... (Rasatarangini 1/ 13) (Anandakanda 2/22) ...... ( R.R.S 7/1)
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Cont
Where there is no obstacles of any kind.
Where all the medicinal herbs are available. beautiful

well
Equipped with equipments. Compound wall

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Working Area:
A very beautiful and vivid description with regards to the site and the building of Rasa Salais found mentioned in the Rasa literature along with its working arrangements, various divisions, spiritual rituals, qualities of its employees and the types of equipments to be collected for completion of various Rasa operations and pharmaceutical processes and procedures.

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Cont
Here the different types of pharmaceutical operations

have been found divided on the basis of different directions to achieve highest success in these operations on account of the blessings of Gods ruling these directions.

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The working arrangements of Rasa Sala have been divided into eight divisions:
Poorvadik (East) Agnikona (South East) Yamyabaga( South) Nairityakona( South West) Varunabaga(West) Vayavyakona(North West) Utharadigbaga(North) Isanakona( North East)
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: I (Rasatarangini 3/3)
The statue of Rasa Bhairava should be installed in

the Eastern direction of the factory. Starting and entering point.

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Rasamandapam
I .......... (R.R.S 6/14)
Constructed in a plain and concealed area.
Eight pettaled lotus design Centre, mercury is placed in a mortar. Surrounding this mortar, a hexagonal design is drawn

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Cont..
Each corner -Diamond, Flourspar, Black

Mica,Magnatite, Borax and Earth worm extract. Centre- Sulphur, Yellow orpiment, Green Vitreol, Realgar, Gamboze, Galena, Lapis lazuli and ochre are placed End-Calamine, Iron pyrites, Copper -pyrites, Bismuth, Blue vitreol, Stybnites, Corraline ore and peacock ore are placed.
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Installation of Rasalinga
......... (R.R.S 6/17) Gold leaves - 3 Nishka (72 ratti or 4.5 grm) Parada - 9 Nishka (216 ratti or 13.5 grm)
Rubbed with Nimba Juice( 3 hours) and Shiva linga is prepared.

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Benefits of worshipping Rasalingam:


I II (R.R.S 6/19) Equal to worshipping one thousand crore Sivalingas. Seeing, eradicate the sins acumalated due to killing of thousand brahmins and lakhs of cows. Touch, attain Moksha

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Method of Worship
I ( R.R.S 6/21)
Worshipped by chanting Aghora Mantra.

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....
The operations related to the use of fire are advised to

be carried out in Agnikona (South east direction) which is considered to be ruled by God Agni who by virtue of his being the God of fire keeps control on fire related works (operations) thus the success in such operations is always expected if such works are performed in this direction.

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....
The Nairitya Kona (South west direction) is

advised for performing Sastra Karmas like cutting, slicing etc. As this direction is ruled by Raksasas (Demons) who are cruel in nature and keeps the control on sharp weapons /instruments. Hence the cutting, slicing etc. operations invoving the use of sharp instruments if done in this direction may likely to be completed safely and successfully with the blessing of the Demons
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I
The Varuna bhaga (western part) of the factory is

advised for washing ,cleaning etc. works involving the use of water . As this direction is ruled by God Varuna who is considered to be the God of water resources , hence the operations invoving the use of water if done in this direction will never face water shortage and get completed successfully with the blessings of God Varuna.

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...
The Vayavya Kona(North West directions) is ruled

by the God vayu,who is supposed to control wind blowing. The drying operations of the drugs /materials/ and the preparations if done in this direction will never face blowing wind shortage and get dried easily with the blessings of God Vayu.

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II
The Uttara digbhaga (Northern part) is governed by

God Kuvera who is considered to be the God of wealth and finances . Hence the Vedha Karmas(Transformation operation of lower metals into higher metals) are advised to be done in this direction

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I
The Isana Kona (North eastern direction) is ruled

by Lord Siva/rudra who is considered to be the creator of mercurial operations. The transformed mercurial products and the other finished products if stored in this direction then their potency and effectiveness will be preserved for long time and there self life will be very prolonged one.

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Equipments:

I
(R.R.S 7/6)

Koshtis Storage Tanks Bhastrikas(bellows) Mettalic and Bamboo pipes.

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Vessels and utensils of different size

(Gold,Iron,Copper,Bronze, leather and stones) Different types of kandani(small pounder) Peshani(Bigger,flat stone for rubbing) Droni(Big cauldron) Mortars and pestles of different kinds Taptakhalva

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Fuels:

......
Synonyms of Coal:
1.
2. 3.

(R.R.S 7/18)

4.

Shikitra Pavakochista Angara Kokila

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Cow-dung Cakes
Synonyms
Pistaka Changana Chana Upala Utpala

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Appointment of Physician:
Who has studied Rasasastra well

He should have proper access to NighantuSastra


Who is well versed in the languages of all the(nearby)

countries. Amrita hasta (R.R.S 7/23)

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Qualities of Sisya:
Obey the Guru Truthful

:I
( Anandakanda 2/7)

Strong determination to work


Devoid of pride and greed peaceful and always devoted in practising mantra

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Attendant:
Having good conduct and be clean
Strong and courageous more industrious

well born and more faithfull

( R.R.S 7/25)

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Balikarma
Person who is strong Truthful

Having Red eyes with black complexion


Capable of warding off the evilspirits

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Dhatuvada:
Rich person Possess all types of instruments

follows the advice of Guru

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Kalini woman:
Curly hairs Beautiful eyes like lotus

Good Body stature

Kalini woman is extremely good in bringing about the success in Rasabandha and such other Rasayana process. (R.R.S 6/33-37)
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Qualities of the King: : ....


(Anandakanda 2/20)
Kind to the people Fear in

Strong Knowledge in
Truthful

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Importance of GMP
GMP is an essential and significant step

taken by the government of India in improving the quality & standard of ASU (Ayurveda, Sidha & Unani)

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GMP are prescribed to ensure that:


Raw materials used in the manufacture of the drugs are authentic of prescribed quality & are free from contamination. 2. The manufacturing process has been prescribed to maintain the standard. 3. Adequate quality control measures are adopted. 4. The manufactured drug which is released for sale is of acceptable quality.
1.

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To achieve the objects listed above, each licencee shall

evolve methodology & procedure for following the prescribed process of manufacture of drugs, which should be documented as a manual & kept for references & inspection. Building used for the factory shall conform the conditions laid down in the factories Act,1948. Factory premises should have minimum covered area of 1200 sq.ft.

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Water System: There shall be validated system for treatment of water drawn from own or any other source to render it potable in accordance with standards specified by the Bureau of Indian standards or Local Municipality.

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The manufacturing plant should have adequate space for:


Receiving & storing raw materials. Manufacturing process area.

Quality Control section.


Finished goods store. Office.

Rejected goods/drug store.


Rest and Refreshment Rooms
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Specifications:
Specification have made about the batch of

manufacturing, reference during the process of preparation etc. specific records of the market complaints will also have to be maintained. Provisions for quality control have also been made through a separate quality control section.

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One qualified person with degree in Aurveda, Sidha &

Unani should be posted in the quality control section. This is the mandatory requirement. In addition , they may have experts in pharmacy, pharmacognosy & chemistry. The quality control will be as per the prescribed pharmacopeial standards of ASU drugs. However where tests are not available, the test is enforced according to the manufacturers specification or other information available may be given.
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Cont.
Specification for other manufacturing activities like

pill making, capsuling etc have been specified.


The GMP has also recommended the various

equipments required for carrying out various manufacturing procedures.

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Equipments:
Disintegrator
Micropulverizer Juicer

Granulator
Tablet Punching Machine Heater Cutter Grinder

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Disposal of Waste:
The disposal of sewage and effluents from the

manufactory shall be in conformity with the requirements of Environment Pollution Control Board. Effluent water treatment plant. All Biomedical waste shall be destroyed as per Bio medical Waste Rules,1996.

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The implementation of GMP will increase the faith in public about the quality of ASU drugs.

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Future:
This step of government will therefore increase

the domestic as well as export business of ASU drugs.

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Conclusion
In Rasasala, Medicines are prepared according to

classics and in traditional way. In GMP certified Pharmacy, Medicines are prepared in Bulk. Preservatives. Quality of Medicines.

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THANK YOU

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