BLOOD COAGULATION AND ANTICOAGULANT, THROMBOLYTIC, AND ANTIPLATELET DRUGS

Alfi Yasmina Dea Arie Kurniawan

Antikoagulan, Antitrombotik, Trombolitik, Hemostatik

Beberapa Istilah Hemostasis Koagulasi Trombosis Antikoagulan Antitrombotik Trombolitik Hemostatik

Antikoagulan
Indirect Trombin Inhibitor
Heparin Warfarin Rivaroxaban

Direct Trombin Inhibitor

Bivalirudin, Hirudin, Lepirudin, Argatroban Dabigatran, Ximelagatran

Antikoagulan

LMWH
Bemiparin, dalteparin, enoxaparin, reviparin, fondaparinux

Monitoring pemeriksaan darah Indikasi: trombosis vena, emboli paru, PJR, penyakit jantung iskemik

Antitrombotik Aspirin Dipiridamol Tiklopidin Klopidogrel Epoprostenol (PGI2) Abciximab

Rangsang

Gangguan pada membran sel Fosfolipid membran

Fosfolipase

Lipooksigenase Hidroperoksid

Asam arakidonat

Siklooksigenase

Aspirin

Endoperoksid (PGG2/PGH)

Leukotrien PGE2, PGF2, PGD2, PGI2 Tromboksan A2

Antitrombotik

Indikasi: cegah trombosis pada TIA/stroke, infark miokard, bedah kardiovaskuler, Raynauds phenomen

Trombolitik

Streptokinase Urokinase Plasminogen activator (u-PA, t-PA)

Trombolitik

Indikasi: infark, emboli paru, trombosis vena/arteri Mahal

Hemostatik
Transfusi Faktor VIII Kompleks faktor II, V, IX, X Fibrinogen Vitamin K Asam aminokaproat Asam traneksamat Karbazokrom

Further Reading
Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology 11th Edition. McGraw-Hill, 2009. Goodman & Gilmans Manual of Pharmacology and Therapeutics. McGraw-Hill, 2008